Glutargin - instructions for use, reviews, analogs and forms of release (tablets 0.25 g, 0.75 g, 1 g, injections in ampoules for injection, powder for ingestion of Alkoklin) for the treatment of cirrhosis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Glutargin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Glutargin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Glutargin in the presence of existing structural analogs.Use for the treatment of cirrhosis of liver, hepatitis, hepatic encephalopathy in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Glutargin - a combination of arginine and glutamic acid, which play an important role in providing biochemical processes of neutralizing and removing from the body a highly toxic metabolite of nitrogen-containing substances - ammonia. Hypoammonemic effect of the drug is realized as a result of activation of ammonia neutralization in the ornithine cycle of urea synthesis, binding of ammonia to nontoxic glutamine, as well as increased removal of ammonia from the central nervous system and its excretion from the body. Due to these properties, Glutargin reduces the general toxic, as well as neurotoxic, action of ammonia.

Glutargin also has a hepatoprotective effect, has antioxidant, antihypoxic and membrane stabilizing activity, positively affecting the energy supply of hepatocytes. With alcohol intoxication, Glutargin stimulates the utilization of alcohol in the monooxygenase system of the liver, prevents the inhibition of the key enzyme for the utilization of ethanol - alcohol dehydrogenase; accelerates the inactivation and elimination of toxicproducts of ethanol metabolism as a result of increased formation and oxidation of succinic acid; reduces the oppressive effect of alcohol on the central nervous system due to the neurotransmitter properties of glutamic acid.

Composition

Arginine glutamate + excipients.

Indications

• acute and chronic hepatitis of various etiologies;
• poisoning with hepatotropic poisons (poison pallid grebe, chemical substances and drugs);
• cirrhosis of the liver;
• liver damage with leptospirosis;
• hepatic encephalopathy;
• Precoma and coma, caused by hyperammonemia.
• the state of acute alcohol poisoning of medium and severe degree, incl. alcoholic encephalopathy and coma;
• Post-toxicity disorders caused by alcohol intake.

Forms of release

Tablets 0.25 g, 0.75 g, 1 g.

Concentrate for the preparation of a solution for infusions (injections in ampoules for injections).

Powder for solution for oral administration (Glutargin Alkoklin).

Instructions for use and reception scheme

Pills

Orally administer 3 tablets (0.75 g) to adults 3 times a day for 15 days, regardless of food intake. If necessary, the dose of the drug and the course of treatment can be increased up to 20 days.The highest single dose is 2 g, the highest daily intake is 8 g.

Ampoules

Intravenous drip is administered 2 times a day for 2 g in 150-250 ml of isotonic sodium chloride solution at a rate of 60-70 drops per minute. The course of treatment is 5-10 days. The highest daily dose is 8 g.

Powder

The drug is prescribed to adults inside, regardless of food intake, previously dissolving the package in 1 / 4-1 / 2 cups of water.

To prevent intoxication and hepatotoxic action of alcohol, 2 packets (2 g of arginine of glutamate) are prescribed 1-2 hours prior to alcohol intake or 1 packet (1 g of glutamate arginine) 1 h before alcohol intake and 1 packet (1 g of glutamate arginine) for 0.5 h after taking alcohol.

For the treatment of acute alcohol intoxication of mild and moderate severity, 1 packet (1 g of arginine of glutamate) is administered 4 times a day at intervals of 1-2.5 hours, in the following 2-3 days - 1 packet (1 g of arginine glutamate) 2 times a day . For severe alcohol poisoning, after a course of intravenous administration of Glutargin, 1 packet (1 g arginine of glutamate) of Glutargin alkoklin is prescribed 2 times a day for 20 days as part of complex therapy.

Side effect

• feeling of mild discomfort in the epigastric region and nausea immediately after application of the drug, which pass independently.

Contraindications

• children's age till 18 years;
• During pregnancy and breastfeeding;
• phenylketonuria, since the drug contains aspartame;
• acute psychosis;
• hypersensitivity to the components of the drug.

Carefully:

• feverish condition;
• increased excitability;
• severe violations of the filtration (nitrogen excretory) function of the kidneys (creatinine clearance less than 30 ml / min).

Application in pregnancy and lactation

Glutargin is contraindicated during pregnancy and lactation.

Use in children

Contraindicated in children and adolescents under the age of 18 years.

special instructions

When appointing patients with impaired functions of the endocrine glands, it should be taken into account that the drug may slightly increase the secretion of insulin and growth hormone, which does not require correction of medical therapy in patients with diabetes mellitus and / or acromegaly.

Effect of the drug on the ability to drive vehicles

The drug does not affect the ability to drive vehicles.

Drug Interactions

Aminophylline increases the concentration of endogenous insulin in the blood under the influence of Glutargin.

Glutargin can enhance the effect of antiplatelet agents (dipyridamole and others), prevents and weakens neurotoxic phenomena that may occur with Isoniazid therapy, weakens the effect of vinblastine.

Analogues of the drug Glutargin

Structural analogs for the active substance:

• Glutargin Alkoklin.

Analogues for the pharmacological group (hepatoprotectors):

• Alpha lipoic acid;
• Berlition;
• Bondjigar;
• Vitanorm;
• HepaMerz;
• Gepabene;
• Hepafor;
• Heptor;
• Heptral;
• Grinterol;
• Covechol;
• Karsil;
• Karsil Forte;
• Laennek;
• Legalon;
• Liv 52;
• Liv 52 K;
• Livedoksa;
• Lipoic acid;
• Lasfall;
• Methionine;
• Moliksan;
• Octolipen;
• Ornilatex;
• Ornitsetil;
• Progepar;
• Resalute Pro;
• Sibektan;
• Silegon;
• Silibinin;
• Sylimar;
• Silymarin;
• Thioctic acid;
• Tiotriazolin;
• Ursodez;
• Ursodeoxycholic acid;
• Ursodex;
• Ursuliv;
• Ursoprim;
• Ursor;
• Ursosan;
• Ursofalk;
• Phosphogliv;
• Phosphogliv Forte;
• Phosphontsiale;
• Hepabos;
• Holudexan;
• Exxhol;
• Erbisol;
• Eslidine;
• Essentiale;
• Essentiale forte N;
• Essential phospholipids;
• Essley forte;
• The Essler;
• Essliver forte.

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