En DE FR ES PL
Novigan - instructions for use, analogs, reviews and release forms (tablets) of the drug for the treatment of headaches and dental pain, during menstruation in adults, children and pregnancy. Composition of pain medication

Novigan - instructions for use, analogs, reviews and release forms (tablets) of the drug for the treatment of headaches and dental pain, during menstruation in adults, children and pregnancy. Composition of pain medication

In this article, you can read the instructions for the use of an anesthetic drug Novigan. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Nogravana in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Nourvahn in the presence of existing structural analogues. Use for the treatment of headaches and dental pain, during menstruation in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

 

Novigan - combined preparation, has analgesic, anti-inflammatory and antispasmodic effect. Suppress the synthesis of prostaglandins. The composition of the drug includes a non-steroidal anti-inflammatory drug (NSAID) ibuprofen, myotropic antispasmodic drug pituophenone hydrochloride and m-cholinoblocking agent of central and peripheral action of fenpiverinium bromide.

 

Ibuprofen is a derivative of phenylpropionic acid. Has analgesic, anti-inflammatory and antipyretic effect (reduces elevated body temperature). The main mechanism of action is oppression of the synthesis of prostaglandins - modulators of pain sensitivity, thermoregulation and inflammation in the central nervous system and peripheral tissues. In women with primary dysmenorrhea, the elevated level of prostaglandins in myometrium is reduced and, as a result, reduces intrauterine pressure and the frequency of uterine contractions.

 

Pitofenone hydrochloride has a direct myotropic effect on the smooth muscles of the internal organs and causes it to relax.

 

Fenpiverinia bromide due to anticholinergic action has an additional relaxing effect on smooth muscle.

 

The combination of the three components of the drug leads to a mutual enhancement of their pharmacological action.

 

Composition

 

Ibuprofen + Petophenone hydrochloride + Fentpuverinium bromide + excipients.

 

Pharmacokinetics

 

When ingested, the components of Novigan are well absorbed into the digestive tract. The main component of the drug Ibuprofen 99% binds to blood plasma proteins, accumulates in the synovial fluid. Ibuprofen is metabolized in the liver and excreted 90% with urine in the form of metabolites and conjugates. A small part of ibuprofen is excreted with bile.

 

Indications

  • mild or moderate pain syndrome with spasms of smooth muscles of internal organs: renal and biliary colic, biliary dyskinesia, intestinal colic;
  • dysmenorrhea;
  • headache, incl. migraine nature;
  • short-term symptomatic treatment for pain in the joints, neuralgia, ischialgia, myalgia.

 

Forms of release

 

Tablets coated with 400 mg + 5 mg + 100 μg.

 

Instructions for use and dosing regimen

 

Inside, 1 hour before or 3 hours after eating. To avoid irritating effects on the stomach, you can take the drug immediately after eating or drink milk.

 

In the absence of special doctor's instructions Novigan is recommended to take 1 tablet up to 3 times a day for spasmodic pain. The maximum daily dose is 3 tablets. Do not exceed the indicated dose!

 

The course of treatment with Novigan, without consulting a doctor, should not exceed 5 days. Longer use is possible under the supervision of a physician with control of peripheral blood and functional state of the liver.

 

Side effect

  • NSAIDs-gastropathy (abdominal pain, nausea, vomiting, heartburn, loss of appetite, diarrhea, flatulence, constipation, ulceration of the gastrointestinal mucosa, which are sometimes complicated by perforation and bleeding, irritation or dryness of the oral mucosa, pain in the mouth, ulceration of the gingival mucosa, aphthous stomatitis);
  • pancreatitis;
  • hepatitis;
  • dyspnea;
  • bronchospasm;
  • headache;
  • dizziness;
  • insomnia;
  • anxiety;
  • nervousness and irritability;
  • psychomotor agitation;
  • drowsiness;
  • depression;
  • confusion of consciousness;
  • hallucinations;
  • aseptic meningitis (more often in patients with autoimmune diseases);
  • hearing impairment;
  • hearing loss;
  • tinnitus;
  • visual impairment (toxic damage to the optic nerve, blurred vision, scotoma, dry and irritated eyes, conjunctival edema and eyelids (allergic genesis), paresis of accommodation);
  • heart failure;
  • tachycardia;
  • increased blood pressure;
  • acute renal insufficiency;
  • allergic nephritis;
  • nephrotic syndrome (edema);
  • oliguria, anuria, polyuria;
  • proteinuria;
  • cystitis;
  • staining the urine in red;
  • skin rash (usually erythematous or urticaria);
  • itching;
  • angioedema;
  • anaphylactoid reactions;
  • anaphylactic shock;
  • bronchospasm or dyspnoea;
  • fever;
  • multi-form exudative erythema (including Stevens-Johnson syndrome);
  • toxic epidermal necrolysis (Lyell's syndrome);
  • eosinophilia;
  • allergic rhinitis;
  • anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia;
  • increased or decreased sweating.

 

Contraindications

  • erosive and ulcerative changes in the mucous membrane of the stomach or duodenum, active gastrointestinal bleeding;
  • Inflammatory bowel disease in the phase of exacerbation, incl. ulcerative colitis;
  • anamnestic data on an attack of bronchial obstruction, rhinitis, urticaria, after taking acetylsalicylic acid or other NSAIDs (complete or incomplete acetylsalicylic acid intolerance syndrome - rhinosinusitis, urticaria, polyps of the nasal mucosa, bronchial asthma);
  • hepatic insufficiency or active liver disease;
  • renal failure (QC less than 30 ml / min), progressive kidney disease;
  • confirmed hyperkalemia;
  • hemophilia and other disorders of blood clotting (including hypocoagulation), hemorrhagic diathesis;
  • period after aortocoronary shunting;
  • acute intermittent porphyria;
  • granulocytopenia;
  • disorders of hematopoiesis;
  • deficiency of glucose-6-phosphate dehydrogenase;
  • tachyarrhythmias;
  • angle-closure glaucoma;
  • diseases of the optic nerve;
  • hyperplasia of the prostate;
  • intestinal obstruction;
  • pregnancy;
  • lactation period (breastfeeding);
  • age to 16 years;
  • hypersensitivity to any component of the drug.

 

Carefully:

  • elderly age;
  • congestive heart failure;
  • cerebrovascular diseases;
  • arterial hypertension;
  • ischemic heart disease (IHD);
  • dyslipidemia / hyperlipidemia;
  • diabetes;
  • diseases of peripheral arteries;
  • nephrotic syndrome;
  • CK less than 30-60 ml / min;
  • hyperbilirubinemia;
  • peptic ulcer of the stomach and duodenum (in the anamnesis);
  • presence of Helicobacter pylori infection;
  • gastritis, enteritis, colitis;
  • long-term use of NSAIDs;
  • blood diseases of unclear etiology (leukopenia, anemia);
  • smoking;
  • frequent use of alcohol (alcoholism);
  • severe physical illness;
  • concomitant therapy with the following drugs: anticoagulants (eg, warfarin), antiaggregants (eg, acetylsalicylic acid, clopidogrel), oral glucocorticosteroids (for example, prednisolone), selective serotonin reuptake inhibitors (eg, citalopram, fluoxetine, paroxetine, sertraline).

 

Application in pregnancy and lactation

 

Novigan is contraindicated in pregnancy and lactation (breastfeeding).

 

Use in children

 

Contraindicated in children under 16 years of age.

 

Application in elderly patients

 

Caution should be used in elderly patients.

 

special instructions

 

With long-term use, control of the peripheral blood picture and the functional state of the liver and kidneys is necessary.

 

To reduce the risk of developing adverse events from the gastrointestinal tract, the minimum effective dose should be used. When symptoms of gastropathy appear, careful monitoring is performed, including esophagogastroduodenoscopy, blood analysis with determination of hemoglobin and hematocrit, analysis of feces for latent blood.

 

If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the test.

 

During treatment should refrain from drinking alcohol.

 

Impact on the ability to drive vehicles and manage mechanisms

 

During the treatment period, the patient should refrain from engaging in potentially dangerous activities that require a high concentration of attention and speed of psychomotor reactions.

 

Drug Interactions

 

In therapeutic doses Novigan does not enter into significant interactions with widely used drugs.

 

Inducers of microsomal oxidation enzymes in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone,tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe intoxication.

 

Inhibitors of microsomal oxidation reduce the risk of hepatotoxic action.

 

The drug reduces the hypotensive activity of vasodilators and natriuretic effect of Furosemide and hydrochlorothiazide.

 

Reduces the effectiveness of uricosuric drugs.

 

Strengthens the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics (which increases the risk of bleeding).

 

Increases the side effects of mineralocorticoids, glucocorticoids (increases the risk of gastrointestinal bleeding), estrogens, ethanol (alcohol).

 

Enhances the hypoglycemic effect of sulfonylurea derivatives.

 

Antacids and colestyramine reduce the absorption of ibuprofen.

 

The drug increases the concentration of digoxin, lithium preparations, Methotrexate in the blood.

 

Strengthens the effect of m-holinoblokatorov, blockers of histamine H1-receptors, butirofenonov, phenothiazines, amantadine and quinidine.

 

Simultaneous administration of other NSAIDs increases the incidence of side effects.

 

Caffeine increases the analgesic effect.

 

With simultaneous administration reduces the anti-inflammatory and antiplatelet effect of Acetylsalicylic acid (it is possible to increase the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent after the Novigan drug is started).

 

Cefamandol, cefoperazone, cefotetan, valproic acid, plikamycin increase the frequency of hypoprothrombinemia with simultaneous administration.

 

Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.

 

Cyclosporine and gold preparations increase the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by increased nephrotoxicity.

 

Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of its hepatotoxic effects.

 

Drugs that block tubular secretion, reduce excretion and increase the plasma concentration of ibuprofen.

 

Analogues of the drug Novigan

 

Structural analogs for the active substance:

  • Novospaz.

 

Analogues on the curative effect (funds for the treatment of migraine):

  • Amigrenin;
  • Amitriptyline;
  • Analgin;
  • Anaprilin;
  • Andipal;
  • Ascofen;
  • Betalk;
  • Vazobral;
  • Voltaren;
  • Diclofenac;
  • Dimephosphone;
  • Zomig;
  • Ibufen;
  • Inderal;
  • Ipronal;
  • Caffetin;
  • Ketonal;
  • Contamnol;
  • Korgard;
  • Xantinol nicotinate;
  • Kudevita;
  • Lexotan;
  • Metovit;
  • Metoprolol;
  • MIG 200;
  • Naisylate;
  • Naklofen;
  • Nalgezin;
  • Next;
  • Nilogrin;
  • Noblessite;
  • NovoPassit;
  • Nomigren;
  • Nurofen;
  • Nurofen for children;
  • Obsidan;
  • Omaron;
  • Ormidol;
  • Panadine;
  • Panadol;
  • Paracetamol;
  • Pentalgin;
  • Peritol;
  • Pikamilon;
  • Pliwalgin;
  • Propranolol;
  • Revalgine;
  • Redergin;
  • Rudotel;
  • Solpadein;
  • Stugeron;
  • Sumygamren;
  • Topamax;
  • Upsarin of the UPSA;
  • A sedative (sedative) collection;
  • Faspik;
  • Febricet;
  • Fezam;
  • Flamax;
  • Hyrumat;
  • Cefekon D;
  • Cinnarizine;
  • Citrapac;
  • Egilok;
  • Estecor;
  • Efkamon.

Similar medicines:

Other medicines:

Reviews (0):

Rules for publishing reviews and visitor questions