Arpefly - instructions for use, reviews, analogs and form of release (tablets 50 mg and 100 mg) of an antiviral drug for the treatment and prevention of influenza, ARVI in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Arpeflu. Presented are reviews of visitors to the site - consumers of this medication, as well as the opinions of medical experts on the use of Arpefl in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Arpeflu Analogs in the presence of existing structural analogs. Use for the treatment and prevention of influenza, ARVI in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Arpeflu - antiviral, has an immunomodulatory and anti-influenza action, specifically suppresses influenza A and B viruses.

Has interferon-inducing properties, stimulates humoral and cellular immunity reactions, phagocytic function of macrophages, increases the body's resistance to viral infections. It prevents the development of post-influenza complications, reduces the frequency of exacerbations of chronic diseases, normalizes immunological indices. The antiviral effect is due to the suppression of the fusion of the lipid envelope of the virus with the cell membranes upon contact of the virus with the cell.

The therapeutic effectiveness of influenza is manifested in a decrease in intoxication and severity of catarrhal phenomena, shortening of fever periods and the overall duration of the disease. It refers to low-toxic medicinal products (LD 50 more than 4 g / kg). Does not have any negative effects on the human body when administered orally at recommended doses.

Composition

Ethyl 6-bromo-5-hydroxy-1-methyl-4-dimethylaminomethyl-2-phenylthiomethylindole-3-carboxylic acid hydrochloride monohydrate + auxiliary substances.

Pharmacokinetics

Absorption is fast.Quickly distributed to organs and tissues. Metabolised in the liver. About 40% is excreted unchanged, mainly with bile (38.9%) and in an insignificant number of kidneys (0.12%). During the first day, 90% of the administered dose is withdrawn.

Indications

Prevention and treatment in adults and children:

• influenza A and B;
• acute respiratory viral infections (acute respiratory infections) (including those complicated by bronchitis, pneumonia);
• secondary immunodeficiency states.

Complex therapy of chronic bronchitis, pneumonia and recurrent herpetic infection.

Prevention of postoperative infectious complications and normalization of immune status in adults.

Forms of release

Tablets coated with 50 mg and 100 mg.

Instructions for use and dosing regimen

Inside, before eating. Single dose: children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg (2 tablets of 100 mg or 4 tablets of 50 mg).

For non-specific prophylaxis

In direct contact with patients with influenza and other ARVI: children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg 1 time per day for 10-14 days.

During the epidemic of influenza and other SARS,to prevent exacerbations of chronic bronchitis, relapse of herpetic infection: children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg 2 times a week for 3 weeks.

Prevention of postoperative complications: children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years and adults - 200 mg 2 days before surgery, then 2 and 5 days after surgery.

For treatment

Influenza, other SARS without complications: children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg 4 times a day (every 6 hours) for 5 days.

Influenza, other acute respiratory infections with complications (bronchitis, pneumonia and others): children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg 4 times a day (every 6 hours ) for 5 days, then a single dose once a week for 4 weeks.

Side effect

• allergic reactions.

Contraindications

• children's age (up to 3 years);
• the presence of such diseases as galactose intolerance, lactase deficiency, glucose-galactose malabsorption;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Not noted.

Use in children

Contraindicated in children under 3 years.

special instructions

It does not show central neurotropic activity and can be used in medical practice for preventive purposes in practically healthy persons of various professions, including those requiring increased attention and coordination of movements (transport drivers, operators, etc.).

Drug Interactions

When prescribed with other drugs, no negative effects were observed.

Analogues of the drug Arpeflu

Structural analogs for the active substance:

• Arpetol;
• Arpetolide;
• Methylphenylthiomethyl-dimethylaminomethyl-hydroxybromoindole carboxylic acid ethyl ester;
• ORVITOL.

Analogues for the pharmacological group (antiviral agents):

• Aktaviron;
• Alloferon;
• Alfaferon;
• Amizon;
• Amiksin;
• Anaferon;
• Anaferon child;
• Arbidol;
• Acyclovir;
• Valaciclovir;
• Valtrex;
• Virazole;
• Viferon;
• Wallferon;
• Genferon;
• Herpferon;
• Hyporamine;
• Groprinosin;
• Daklins;
• Devirs;
• Zovirax;
• Imichimod;
• Ingavirin;
• Ingaron;
• Inosin pranobex;
• Inter;
• Interferon leukocyte human;
• Inferon;
• Kagocel;
• Lavomax;
• Layfferon;
• Lokferon;
• Midantan;
• Nevirapine;
• Neovir;
• Nikavir;
• Oxolin;
• Orvire;
• Panavir;
• Proteflazide;
• Realdiron;
• Reaferon EU Lipint;
• Relenza;
• Remantadine;
• Ribavirin;
• Rimantadine;
• Ronbetal;
• Sovriad;
• Sunvepra;
• Tamiflu;
• Thilaxin;
• Tyloron;
• Triazavirin;
• Famciclovir;
• Ferrovir;
• Cyclovir;
• Extavia;
• Erazaban;
• Ergoferon.

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