Chloropyramine - instructions for use, reviews, analogs and forms of release (25 mg tablets, injections in injections) antihistamine drug for the treatment of allergies, hives, rashes in adults, children and pregnancy. Composition

In this article, you can read the instructions for using an antihistamine drug Chloropyramine. Comments of visitors of the site - consumers of this medicine, as well as opinions of doctors of specialists on the use of Chloropyramine in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Chloropyramine in the presence of existing structural analogues.Use for the treatment of allergies, hives, rashes, hay fever in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Chloropyramine - blocker of histamine H1 receptors, ethylenediamine derivative. Has antiallergic and antipruritic effect. Causes sedation. It has peripheral anticholinergic activity, moderate spasmolytic properties.

Composition

Chloro-pyramine hydrochloride + excipients.

Pharmacokinetics

After ingestion of chloropyramine hydrochloride is quickly and completely absorbed from the digestive tract. Regardless of the route of administration, it is well distributed in the body, including the CNS. The binding of chloropyramine to plasma proteins is 7.9%. The binding peak was noted at pH 7.4. Metabolised in the liver. It is excreted mainly by kidneys in the form of metabolites. In children, excretion is faster than in adults.

Indications

• allergic diseases, incl. urticaria, serum sickness, angioedema, pollinosis (hay fever), allergic rhinopathy, allergic conjunctivitis;
• skin diseases, incl.contact dermatitis, acute and chronic eczema, drug rashes, itchy dermatoses;
• itching with insect bites.

Forms of release

Tablets 25 mg.

Solution for intravenous and intramuscular injection (injections in ampoules for injection).

Other dosage forms, be it ointment or cream, at the time of publication the drug in the Directory did not exist.

Instructions for use and dosage

Pills

When administered to adults - 25 mg 3-4 times a day, children depending on their age - to 6.25-12.5 mg 2-3 times a day. The maximum dose for adults is 150 mg per day.

Ampoules

Intravenous or intramuscular.

Adults appoint 20-40 mg per day (the contents of 1-2 ampoules).

Treatment in children begins with a dose of 5 mg (0.25 ml). In the future, the dose is increased depending on the age of the child.

Children aged 1-12 months - 5 mg (0.25 ml).

Children aged 1-6 years - 10 mg (0.5 ml).

Children aged 7-18 years - 10-20 mg (0.5-1 ml).

The daily dose should not exceed 2 mg / kg of body weight.

In severe allergy, treatment should begin with an injection form of chloropyramine. First it is injected / slowly, then goes to the / m introduction and in the final phase of treatment they switch to taking the pills inside.The terms of treatment are set individually depending on the clinical symptoms and the patient's condition.

Elderly, emaciated patients: the use of the drug chloropyramine requires special care, tk. In these patients, antihistamines often cause side effects (dizziness, drowsiness).

Patients with impaired liver function: a dose reduction may be required due to a decrease in the metabolism of the active component of the drug in liver diseases.

Patients with impaired renal function: it may be necessary to change the regimen of the drug and reduce the dose due to the fact that the active component is mainly released through the kidneys.

Side effect

• lethargy;
• weakness;
• drowsiness;
• dizziness;
• headache;
• euphoria;
• feeling tired;
• irritability;
• tremor;
• convulsions;
• violation of coordination of movements;
• impaired vision;
• dry mouth;
• nausea, vomiting;
• gastralgia;
• diarrhea, constipation;
• loss or increased appetite;
• difficulty urinating;
• decreased blood pressure (usually in elderly patients);
• tachycardia;
• arrhythmia;
• leukopenia, agranulocytosis;
• increased intraocular pressure;
• photosensitization;
• muscle weakness.

Contraindications

• acute attack of bronchial asthma;
• simultaneous use of MAO inhibitors;
• gastric ulcer in the acute stage;
• hyperplasia of the prostate;
• severe respiratory failure;
• newborn children (up to 1 month);
• pregnancy
• lactation period;
• individual hypersensitivity to the drug or its components.

Application in pregnancy and lactation

Chloropyramine is contraindicated in pregnancy and lactation.

Use in children

Treatment in children begins with a dose of 5 mg (0.25 ml). In the future, the dose is increased depending on the age of the child.

Children aged 1-12 months (infants) - 5 mg (0.25 ml).

Children aged 1-6 years - 10 mg (0.5 ml).

Children aged 7-18 years - 10-20 mg (0.5-1 ml).

The daily dose should not exceed 2 mg / kg of body weight.

Contraindicated in early childhood up to 1 month.

Use with caution in children because of the hypersensitivity of this category of patients to antihistamines.

Application in elderly patients

Caution should be used in elderly patients.

special instructions

Caution should be used in elderly patients, with insufficient liver function and / or heart disease.

Use with caution in children because of the hypersensitivity of this category of patients to antihistamines.

With extreme caution should be used orally in patients with closed-angle glaucoma, urinary retention and prostatic hypertrophy.

When administered at night, chloropyramine may exacerbate the symptoms of reflux esophagitis.

Antihistamines can distort the reaction when setting skin allergological tests, therefore, a few days before the planned test, the drug should be discontinued.

When combined with ototoxic drugs, chloropyramine can mask the early manifestations of ototoxicity.

During treatment should be excluded the use of alcohol.

Impact on the ability to drive vehicles and manage mechanisms

In the initial, individually defined period of chloropyramine use, driving of vehicles and employment of other potentially dangerous activities requiring rapidity of psychomotor reactions are not permitted. In the process of further treatment, the degree of restriction is determined depending on the tolerability of the treatment.

Drug Interactions

With the simultaneous use of chloropyramine potentiates the effects of drugs for anesthesia, hypnotics, tranquilizers, analgesics, MAO inhibitors, tricyclic antidepressants, atropine and sympatholytics (this combination requires caution).

With the simultaneous use of chloropyramine and Caffeine or phenamine, there is a decrease or elimination of the oppressive effect of chloropyramine on the CNS.

Simultaneous use with ethanol is not recommended (risk of severe CNS depression).

Analogues of the drug Chloropyramin

Structural analogs for the active substance:

• Suprastin;
• Chloropyramine hydrochloride.

Analogues for the pharmacological group (antihistamines):

• Aviamarin;
• Allegra;
• Allergodyl;
• Allergoferon;
• Allertec;
• Astemizole;
• Gismanal;
• Histaglobin;
• Histalong;
• Histafen;
• Dezal;
• Desloratadine;
• Diazoline;
• Diphenhydramine;
• Doxylamine succinate;
• Donormil;
• Zirtek;
• Zodak;
• Kestin;
• Claritin;
• Clemastine;
• Xizal;
• Levocetirizine;
• Lomilan;
• Loratadine;
• Mebhydrogen;
• Nalorius;
• Parliamentary;
• Pipolphen;
• Reactin;
• Sirep;
• Suprastin;
• Suprastinex;
• Tavegil;
• Telfast;
• Fexofenadine;
• Pheniramine maleate;
• Fenistil;
• Fenspiride;
• Cetirizine;
• Cetrin;
• Ezlor;
• Erespal;
• Erispirus;
• Erius;
• Erolin.

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