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Metrogil - instructions for use, reviews, analogs and forms of release (tablets 200 mg and 400 mg, gel vaginal 1% plus and Denta for dentistry and external 1% solution) for the treatment of infections in adults, children and pregnancy

Metrogil - instructions for use, reviews, analogs and forms of release (tablets 200 mg and 400 mg, gel vaginal 1% plus and Denta for dentistry and external 1% solution) for the treatment of infections in adults, children and pregnancy

In this article, you can read the instructions for using the drug Metrogil. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of physicians specialists on the use of Metrogil in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Metrogil in the presence of existing structural analogues. Use for the treatment of gingivitis, stomatitis, vaginosis and other infectious diseases in adults, children, as well as during pregnancy and lactation.

 

Metrogil antiprotozoal and antibacterial means of a wide spectrum of action. The mechanism of action of the drug consists in the restoration of the 5-nitro group of Metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole reacts with the DNA of a cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria. The active substance of the drug is Metronidazole.

 

Pharmacokinetics

 

After ingestion of a single dose of the drug 200 mg or 400 mg Metrogil quickly and completely absorbed. Has high penetrating ability in tissues (lungs, kidneys, liver, skin), spinal fluid, brain, bile, saliva, amniotic fluid, vaginal secretion, seminal fluid, breast milk. It is excreted by the kidneys (60-80% of the dose), 20% of the drug is excreted unchanged.

 

Indications

  • protozoal infections (amebiasis, trichomoniasis, giardiasis, balantidiasis, trichomonas vaginitis and urethritis, amoebic dysentery);
  • anaerobic infections (caused by Bac.fragilis and other bacteroids, fusobacteria, eubacteria, clostridia, anaerobic cocci);
  • after surgical interventions on the organs of the abdominal cavity and urinary tract (intraperitoneal infections, appendicitis, cholecystitis, peritonitis, liver abscess, postoperative wound infections, postpartum sepsis, pelvic abscesses, peritonitis, including the prevention of postoperative anaerobic infections);
  • infections of the respiratory tract (necrotic pneumonia, lung abscess);
  • septicemia;
  • gas gangrene;
  • osteomyelitis;
  • tetanus;
  • meningitis, brain abscess
  • pink acne (pimples) (including post-steroids);
  • vulgar acne;
  • oily seborrhea, seborrheic dermatitis;
  • trophic ulcers of the lower extremities (against the background of varicose veins, diabetes mellitus);
  • poorly healing wounds;
  • pressure sores;
  • hemorrhoids, anal fissures
  • bacterial vaginosis of different etiology, confirmed by clinical and microbiological data;
  • candidiasis vulvitis and vulvovaginitis;
  • acute and chronic gingivitis;
  • acute ulcerous-necrotic gingivitis of Vincent;
  • acute and chronic periodontitis;
  • juvenile periodontitis;
  • periodontal disease complicated by gingivitis;
  • aphthous stomatitis;
  • cheilitis;
  • inflammation of the oral mucosa during the wearing of prostheses;
  • postextraction alveolitis;
  • periodontitis, periodontal abscess (as part of combination therapy).

 

Forms of release

 

Tablets, film-coated 200 mg and 400 mg.

 

Gel for vaginal application Metrogil Plus 1%.

 

Gel for external use 1%.

 

Solution for intravenous administration (injections in ampoules for injection) 5 mg / ml.

 

Suspension for oral administration.

 

Gel stomatologic Metrogil Denta.

 

Instructions for use and how to use them

 

Pills

 

Inside with food or after eating, without chewing or squeezing milk.

 

Adults and children over 15 years of age - 200-400 mg 2-3 times a day.

 

The dose of the drug and the course of treatment is determined by the nature of the infection.

 

Trichomoniasis: 200 mg 3 times a day for 7 days; women need to additionally prescribe metronidazole in the form of vaginal suppositories or vaginal ointments. If necessary, you can repeat the course of treatment or increase the dose to 750-1000 mg per day. Between the courses should be a break in 3-4 weeks with the holding of repeated control laboratory tests. An alternative scheme of therapy is the appointment of 2 g once to the patient and his sexual partner.

 

Amoebiasis: adults - 400 mg three times a day; children - 30-40 mg / kg per day in 3 divided doses. The course of treatment is 7-10 days.

 

Amoebic liver abscess: adults - 400 mg or 800 mg 3 times a day in combination with antibiotics (tetracycline or other methods); children - 30-35 mg / kg per day (in 3 divided doses). The course of treatment is 5-10 days.

 

Anaerobic bacterial infections: adults - 200-400 mg 2-3 times a day; children - 7 mg / kg every 8 hours. The course of treatment - 7-10 days;

 

For the prevention of anaerobic infection before surgery on the pelvic organs and the large intestine appoint a single oral intake of 1000 mg, then - 200 mg 3 times a day.

 

In combination with Amoxicillin (2.25 g / day), the daily dose of metronidazole is 1.5 g, the frequency of administration is 3 times a day.

 

Patients with severe violations of the liver and kidneys daily dose of metronidazole - 1 g, amoxicillin - 1.5 g. The frequency of admission - 2 times a day.

 

Gel

 

For external use. The gel is applied to the previously cleaned lesions of the skin with a thin layer 2 times a day, in the morning and in the evening, for 3-9 weeks.

 

The duration of treatment is 3-4 months, the therapeutic effect is usually noted after 3 weeks of treatment.

 

Candles

 

The drug is administered intravaginally.The recommended dose is 5 g (one complete applicator) 2 times a day (morning and evening). The course of treatment is 5 days. If necessary, the course of treatment can be repeated after 2 weeks.

 

Gel Metrogil Denta

 

The drug is intended only for use in dental practice.

 

Adults and children over 6 years old with gingivitis Metrogil Dent applied to the gum area 2 times a day with a thin layer (finger or with the help of a cotton swab), it is not recommended to rinse the gel. The duration of therapy is an average of 7-10 days. After applying the gel, you should refrain from drinking and eating for 30 minutes.

 

When periodontitis after removal of dental deposits, periodontal pockets are treated with the drug and gel application is applied to the gum area. Exposure time - 30 min. The number of procedures depends on the severity of the disease. In the future, the patient can apply the gel on his own: the drug should be applied to the gum area 2 times a day for 7-10 days.

 

With aphthous stomatitis, the gel is applied to the affected area of ​​the mucous membrane of the oral cavity 2 times a day for 7-10 days.

 

To prevent exacerbations of chronic gingivitis and periodontitis, the gel is applied to the gum area 2 times a day for 7-10 days. Preventative courses are held 2-3 times a year.

 

For the prevention of postextraction alveolitis, the drug is treated with a hole after tooth extraction, then the gel is applied on an outpatient basis 2-3 times a day for 7-10 days.

 

Side effect

  • dry mouth;
  • nausea, vomiting;
  • constipation, diarrhea;
  • pseudomembranous colitis;
  • intestinal colic;
  • glossitis, stomatitis;
  • lack of appetite;
  • unpleasant metallic taste in the mouth;
  • headache;
  • dizziness;
  • impaired consciousness;
  • increased excitability;
  • depression;
  • sleep disturbance;
  • weakness;
  • seizures of epilepsy;
  • peripheral neuropathy;
  • violation of coordination of movements;
  • hallucinations;
  • burning sensation in the urethra;
  • fungal flora of the vagina (candidiasis);
  • red-brown staining of urine;
  • urinary incontinence;
  • nasal congestion;
  • hyperemia of the skin;
  • skin rash;
  • itching;
  • hives;
  • fever;
  • anaphylactic shock;
  • leukopenia, thrombocytopenia.

 

Contraindications

  • organic lesions of the central nervous system (including epilepsy);
  • blood diseases (including in the anamnesis);
  • hepatic failure (in the case of the appointment of large doses);
  • 1 trimester of pregnancy;
  • children's age (up to 12 years);
  • increased sensitivity to metronidazole or components included in the preparation, as well as to other derivatives of nitroimidazole.

 

Application in pregnancy and lactation

 

2 and 3 trimesters of pregnancy - only for life indications; breastfeeding mothers - according to indications, with simultaneous cessation of breastfeeding

 

special instructions

 

During the drug intake, alcohol can not be consumed (it is possible to develop a disulfiram-like reaction: abdominal pain of a spastic nature, nausea, vomiting, headache, sudden rush of blood to the face). Metronidazole is used to treat alcoholism and pathological cravings for alcohol.

 

In combination with amoxicillin it is not recommended to use in patients younger than 18 years.

 

With leukopenia, the possibility of continuing treatment depends on the risk of developing an infectious process.

 

Long-term use of the drug is desirable to be carried out under the control of peripheral blood.

 

The appearance of ataxia, dizziness and any other deterioration in the neurological status of patients requires discontinuation of treatment.

 

Can immobilize treponema and lead to Nelson's false positive test.

 

When treating trichomonadic vaginitis in women and trichomoniasis, men should abstain from sexual activity. It is necessary to simultaneously treat sexual partners. Treatment does not stop during menstruation.After therapy with trichomoniasis, control tests should be performed for 3 consecutive cycles before and after menstruation.

 

After the treatment of giardiasis, if symptoms persist, after 3 to 4 weeks, 3 feces should be analyzed at intervals of several days (in some patients the lactose intolerance caused by the invasion can persist for several weeks or months, recalling the symptoms of giardiasis).

 

Drug Interactions

 

Metronidazole increases the effect of indirect anticoagulants, which leads to an increase in the time of prothrombin formation.

 

Similarly, Disulfiram can cause intolerance to ethanol.

 

Cimetidine inhibits metronidazole metabolism, which can lead to an increase in its serum concentration and an increased risk of side effects.

 

Sulfonamides increase the antimicrobial effect of metronidazole.

 

Simultaneous administration of drugs stimulating enzymes of microsomal oxidation in the liver (phenobarbital, phenytoin) can accelerate the elimination of metronidazole, resulting in a decrease in its concentration in the plasma.

 

It is not recommended to combine metronidazole with depolarizing muscle relaxants (vecuronium bromide).

 

In patients who receive long-term treatment with lithium preparations in high doses, with the use of metronidazole, an increase in the concentration of lithium in the blood plasma and the development of symptoms of intoxication are possible.

 

Analogues of the drug Metrogil

 

Structural analogs for the active substance:

  • Bacimex;
  • Dentamet;
  • Deflamon;
  • Clion;
  • Metrovagin;
  • Metroxan;
  • Metrolacker;
  • Metron;
  • Metronidazole;
  • Metronidazole Nycomed;
  • Metronidal;
  • Metroseptol;
  • Orvagil;
  • Rosamet;
  • Rosex;
  • Siptrogyl;
  • Tricho-PIN;
  • Trichobrol;
  • Trichopol;
  • Trichosept;
  • Flagel;
  • Efloran.

Similar medicines:

Other medicines:

Reviews (21):
Guests
after dental
Metrogil Denta advised the dentist from the terrible gingivitis, which appeared generally on level ground (although before that there was a furuncle, but it may not be connected with this).As a result, I applied this gel three times a day (on the finger and crooked on the gums until I got bored). Everything went surprisingly even to my dentist quickly, which means that the right treatment started in time.
Guests
Nadira
against blackheads helped ... bravo))) wink
Guests
Dinara
I Metrogil Denta appointed a dentist, gingivitis began. Mazala, Mazal, but no use. I was very upset, my gums ached. In the pharmacy auntie I was advised by Holisal, I decided that it would not be any worse. Has bought or purchased, has spread and the pain has passed or has taken place at once, instantly directly, and then and a gum or gingiva have better become. In general Holisal I liked more.

I already once believed and enjoyed Metrogil Dent. Well, it did not help at all. No changes. Maybe the drug is not "mine" turned out. Holisal in this regard coped better.
Guests
Matvey
And I did not dare to buy Metrogil Dent. Chlorhexidine, which in its composition, has a very negative effect on the oral cavity and stains the tooth enamel in a dark color. Do I need this? I used Parodontocid.Gingivitis quickly passed, and for a week and a half with gingivitis it was finished!
Guests
Valentina
My gum ached (I cleaned the thread between my teeth), I got so inflamed that I thought I would remove the tooth. But the dentist prescribed gel metrogil denta and I began to treat. A few days later the inflammatory process completely passed. Of course, it's unpleasant to keep it in your mouth, although the taste was fruity, but I was helped and saved a tooth.
Administrators
admin
Visitor feedback Tatyana moved to the required section:
I was swept by the metrogil's course, nothing incidental. For a long time I forgot about the pains in the appendages. Inflammation has passed.
Visitors
Seven-flower
Metrogyl dentu used many times, very well removes inflammation, but does not replace rinsing. The rest of the gels and candles were not used.
Guests
Nazarova Maria
I was advised in the pharmacy by Dentamet, as a more budgetary alternative to Metrogil.I decided to ask the doctor again on this topic, so he said that in the preparation of Dentamet, the composition would also be better. So I eventually went to the pharmacy for him. And it really helps.
Administrators
admin
Nazarova Maria, Better it that means, chlorhexidine more, so rinse better with chlorhexidine solution there is generally 20% of the active ingredient. And yes, both Dentamet and Metrogil are analogues preparations for the active substance.
Administrators
admin
Site visitor question Elena78 moved to the required section:
Used a gel Metrogil (active in-in metronidazole) on the person from rozatsea. Without tablets, only topically. Twice a day. The effect is very fast! I had rosacea in the stage of redness, severe peeling, papules-vesicles along the "butterfly" zone. So: literally the next day - the skin is even, there are almost no redness, it is more pleasant to look in the mirror and it is quite possible to go outside without a tonalka :). An interesting side effect of skin itching: initially I had no itching at all,and metrogil leads to itching stably after 8-10 hours after application, just at the time of the next application (if to neigh, the impression that the insects-germs collect the suitcases). Stresses the question: will the problem of rosacea return with the withdrawal of the drug? And even more concerned with the question, who caused rosacea, if he died from metrogil? Trichomonases-amoeba :))))))? Pts is weird ...

Elena78, Primarily, rosacea is usually non-infectious causes, and others, their weight and sometimes it is impossible to establish (hobby for scrubs and other injuries of the skin, alcohol abuse, smoking, nutrition, stress, immune factors). Treatment is also selected gradually from a smaller one (external antibacterial agents, glucocorticosteroids in the form of gels or ointments and other drugs) to a larger (tableted and injectable antibiotics, hormonal drugs in tablets, etc.). So, consider it easy to get rid of. Complete the treatment with Metrogil as prescribed by the doctor and want to believe the disease will not return to you anymore, but no one can give guarantees, especially if the factor that caused the disease is not established and not eliminated.
Guests
Nazarova Maria
admin, it's clear that they are analogs. That's just the price of the drug, Dentamet is still less, and the size of the tube is a little more - so it turns out to be more economical. I do not want to overpay anyone. And about chlorhexidine - it's still not the same thing. How many mouths will you rinse - well, a maximum of 5 minutes, right? And I can calmly apply Dentamet for half an hour to the site of inflammation - it is natural that the effect from it will be much better than just from rinsing.
Guests
Lisa Gorbacheva
It amazes me that there are no such drugs in hospitals, my mother got into gynecology, told to buy. We'll buy something, but who can not? And no replacement. It seems to me that the gel metrogila that the solution in gynecology should be constantly in service, considering the universality of their action.
Administrators
admin
Lisa Gorbacheva and the others, competently, subtly, but I noticed for the first time a warning. If you continue and continue to hooligan with advertising reviews (including blacken their competitors in responses to other drugs) very strongly punish, right up to the ban,all marked comrades with such advertising comments, plus Metrogil will be added to the local blacklist and moderation of reviews for him will be significantly tightened. So let's live amicably and more without advertising where it should not be.
Administrators
admin
Advertisers of the drug Metrogil, your obtrusive advertising in the reviews under the guise of ordinary visitors begins to bore. If you do not stop, the drug will be blacklisted. Reorient your human resources to other sites where administrators do not have principles and do not appreciate the respect of ordinary people, but I do not pass this. The last Chinese warning to your team.
Administrators
admin
Requests and persuasions on the advertisers of the drug Metrogil do not work. They continue to throw products that are competitive with their product with advertising reviews, denigrating certain drugs and advertising their own, so it's time for tough measures. From today, the drug in black list. Moderation of reviews for it is significantly toughened, so gentlemen advertisers can no longer try. I warned several times.
Administrators
admin
Site visitor question alexander88 moved to the required section:
Hello. Analysis: Sowing of material on Trichomonas vaginalis (Trichomonas): Rounded fixed forms of Trichomonas vaginalis are found.
The doctor prescribes:
1) metrogyl in the form of droppers 100 ml 2 bottles 2 times a day with an interval of 12 hours - 5 days.
2) combflex 1 tablet 2 times a day - 10 days.
Also a couple of domestic fuflomycins

I have a question, justifiably, the introduction of metrogil (metronidazole) is justified? And also its combination with combflex, which in turn consists of two more.

Complaints are not strong, as a result of the examination, the prostate gland is enlarged, painful. I would not like to be poisoned once again with this dose. Since the nervous system is weak and digestion is a problem. Asthenic.
alexander88, Given that the trichomonads in you are in a vegetative immobile form, then getting to them antibiotic will be problematic, so the use of Metrogil intravenously can be considered justified step, including because of weak GIT (delivering the medicine bypassing the problem organ).

Combiflox understand for what I can not, apparently not the whole picture is presented and there are still some pathogens not indicated in the question, if not, then we can consider the use of this drug as excessive. Although, perhaps, they did additional research on the sensitivity to antibiotics and there something inspired the attending physician to prescribe this drug.

And complaints for this disease do not give anything at all. Trichomoniasis in most patients is generally an asymptomatic process, and you also have a clinic manifested, so that the use of a shock scheme of antibiotics can be considered justified. If you do not heal now, I judge by the clinical picture, problems with the prostate and men's health to old age (and maybe even earlier) are provided.
Visitors
alexander88
Thanks for the reply admin.
Surrendered 2 types of tests, the one that has already described +
DNA Chlamydia trachomatis NOT DENIAL
DNA of ureaplasma is not known
DNA Mycoplasma hominis is not common
DNA Mycoplasma genitalia is not common

That's all. At the next appointment, the doctor already prescribes treatment. As part of the treatment, I forgot to mention prostate massage, 10 times.
Of the concomitant diseases, I have chronic tonsillitis, or nasopharyngitis, who, as they say.
Sowing from the throat showed:
Flora (I) Streptococcus equisimilis (bcC)
Degree of seeding degree of seeding III - 10 ^ 4 cfu / tampon / ml
Amikacin is sensitive
Amoxicillin / Clav.ac. sensible
Ciprofloxacin is sensitive
Chloramphenicol is sensitive
Clindamycin is resistant
Erythromycin is sensitive
Levofloxacin is sensitive
Other Pseudomonas aeruginosa - traces!
Disturb frequent colds and acne, which are exacerbated with a cold.

I also did not understand about combflex. Ornidazole - which in the composition I understand, it is also against trichomonads. May be prescribed for a shock dose. Ofloksatsin - I do not understand why I need this antibiotic, especially Streptococcus spp in most cases is not sensitive to it (from the annotation).

Also ENT has sent me to the immunologist, but I now already have no means for it. Yes, and on vacation I was not very long ago, I feel tired. I think just because of this and showed symptoms of trichomoniasis.

I plan to start treatment next week. I would like to hear your opinion. Perhaps it makes sense to cancel ofloxacin? Doctors do not want to delve into the clinics, and the money has already run out.

Thank you.
Administrators
admin
alexander88, Here now a full picture. Given the concomitant tonsillitis, I would also advise Combiflox. Ornidazole in the antibiotic will support the treatment of trichomoniasis by Metrogil (although oil is oily), and ofloxacin is not bad for your streptococcus. And yes, if the tonsils have already developed their resource, then it may be more logical to remove them than to try to treat them, but your ENT should decide this.

Antibiotics, plus prostate massage - I think treatment of prostatitis is adequate to the situation. To date, all the percussion arsenal count involved, available in medicine, but also bacteria, entrenched in the prostate are treated extremely badly, and judging by symptomatic treatment is necessary. The consequences of this antibiotic therapy will be treated after, but this is a payment for health.
Administrators
admin
Dear advertisers of the drug Metrogil. I see and remove your anti-advertising to other medicines. If you continue your advertising campaign in the same spirit, I will apply sanctions as to distributors-executors of the given advertising spam, and I will write out a ban for the drug itself,the more so the warning for him had already been received earlier. Consider this the last Chinese warning on my part.
Visitors
Nicolay
Question to the doctor. My wife has an atypical ulcerative colitis (NNC), against a background of menopause. Passed 2 courses of treatment permanently in the period of one and a half years. At the moment, home treatment - prescribed salofalk constantly (1000 mg) and zakafalk with a periodicity course in 2 months. There was swelling and weakening of motor functions - increased fatigue, weakness. Metrogil 100 in / in was appointed. After the 2nd system, diarrhea appeared, there was a pressure drop with loss of consciousness. The question is whether the metrogil should be discontinued, and how does it combine with the previously prescribed medications?
Administrators
admin
Nicolay, Understand cancel or continue treatment Metrogilom if your wife is not possible, because there is an active process, in which case some side effects from the use of drugs can be neglected in this case, everything is solved in conjunction with the doctor who prescribed this therapy.

With the names mentioned in the question Salofalkom and Zakofalkom Metrogil is combined and possibly their joint use. According to the instructions, additional side effects from such a combination should not be.

Rules for publishing reviews and visitor questions