Olfen - instructions for use, reviews, analogs and formulations (tablets 50 mg Lactab, 75 mg, capsules 100 mg Depocaps, rectal suppositories Recoctaps, injections in ampoules, patch) medications for pain in adults, children and pregnancy

In this article, you can read the instructions for using the drug Olfen. There are reviews of visitors to the site - consumers of this medication, as well as opinions of physicians specialists on the use of Olfena in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Olfen in the presence of existing structural analogues. Use for the treatment of pain and inflammation in rheumatoid and articular diseases and syndromes in adults, children, as well as in pregnancy and lactation.

Olfen - Anesthetic and anti-inflammatory drug from the group of non-steroidal anti-inflammatory drugs (NSAIDs). The composition of the drug includes the active component of Diclofenac sodium, an enzyme inhibiting cyclooxygenase. Due to the inhibition of cyclooxygenase activity, the synthesis of prostaglandins from arachidonic acid decreases. The decrease in the number of prostaglandins in the affected tissues leads to a decrease in the intensity of the inflammatory process. The analgesic effect of the drug is due to a decrease in the level of prostaglandins in the tissues of the central and peripheral nervous system, as a result of which the susceptibility of nerve cells to irritants decreases, generation is prevented and pain impulses along the nervous structures are slowed. In addition, the drug has antipyretic effect, which is explained by the direct influence of diclofenac on the center of thermoregulation in the hypothalamus. The drug effectively eliminates the morning stiffness, improves mobility of the joints and stops the pain syndrome in patients suffering from diseases of the musculoskeletal system.

Composition

Diclofenac sodium + auxiliary substances.

Diclofenac sodium + Lidocaine hydrochloride + excipients (injections in ampoules for injection Olfen).

Pharmacokinetics

The drug is well absorbed into the systemic circulation by oral and rectal administration. The peak concentration of the active substance in the blood plasma is noted after 0.5-3 hours, depending on the form of release. The drug is characterized by a high degree of connection with plasma proteins. Metabolised in the liver, excreted mainly by the kidneys, both in the unchanged form, and in the form of metabolites. A small part of the drug is excreted by the liver.

When the drug is used in the form of prolonged capsules, the therapeutically significant plasma concentrations of the drug persist for a longer time than with other forms of the drug.

Indications

The drug is used for the relief of pain in degenerative and inflammatory diseases of the musculoskeletal system and soft tissue, including arthritis, osteoarthritis, rheumatoid arthritis, tenosynovitis, bursitis, lumbago, sciatica, gouty arthritis.

The drug can be used to stop the pain syndrome and reduce the edema of tissues in patients who underwent surgery.

The drug is used as an analgesic for primary dysmenorrhea, migraine, renal and hepatic colic.

Olfen can be appointed in the complex treatment of acute infectious diseases of the ENT organs.

Forms of release

Tablets coated with 50 mg Olfen Laktab.

Capsules of prolonged action 100 mg Olfen SR Depocaps.

Solution for injection 75 mg (injections in ampoules for injection).

Rectal Capsules Olfen Rectocaps 100 mg (sometimes mistakenly called rectal suppositories).

Transdermal patch.

Other dosage forms, be it gel, ointment or cream, at the time of publication of the drug card in the Directory did not exist.

Instructions for use and dosage

Alphen 50 tablets Lactab

The drug is intended for oral administration. The tablet should be swallowed whole, without chewing or grinding, with plenty of water. The drug should be taken before meals. The duration of the course of treatment is determined by the attending physician individually for each patient.

Adults usually prescribed 1 tablet of the drug 1-3 times a day.

The maximum daily dose of the drug is 150 mg.

Adults with primary dysmenorrhea usually prescribed 1 tablet of the drug 1-3 times a day. If necessary, the dose can be increased to 1 tablet of the drug 4 times a day. Taking the drug at a dose of 200 mg / day is allowed with primary dysmenorrhea for no more than 4 consecutive cycles.

With prolonged therapy with the drug should not exceed the daily dose of 100 mg of diclofenac.

Capsules prolonged Olfen SR Depocaps

The drug is intended for oral administration. Capsules are recommended to be swallowed whole, without chewing or grinding, with plenty of water. To reduce the risk of side effects, you should take the drug before eating. The duration of the course of treatment is determined by the attending physician individually for each patient.

Adults usually prescribed 1 capsule of the drug 1 time per day.

The maximum daily dose of the drug is 1 capsule.

Adults with primary dysmenorrhea usually prescribed 1 capsule of the drug 1 time per day. If necessary, the dose can be increased to 1 capsule of the drug 2 times a day. Taking the drug at a dose of 200 mg / day is allowed with primary dysmenorrhea for no more than 4 consecutive cycles.

Rectal Capsules Olfen Recoctops

The drug is intended for rectal administration. The capsule should not be divided or shredded. Before use, the capsule may be moistened with water for a more convenient administration. The capsule is injected with a blunt end, after applying the drug to the patient should take a horizontal position and not rise for at least 20 minutes. The duration of the course of treatment and the dose of the drug is determined by the attending physician individually for each patient.

Adults usually appoint 1 capsule or a drug candle 1 time per day.

Injection

The drug is intended for parenteral (intramuscular) administration. Only intramuscular injection of the drug is allowed. The solution is injected deep inside the muscle, usually injections are carried out in the upper outer quadrant of the gluteus muscle. With repeated administration of the drug should be alternated left and right gluteal muscle. The duration of the course of treatment and the dose of the drug is determined by the attending physician individually for each patient.

Adults are usually prescribed 1 ampoule of the drug 1 time per day.

In acute pain syndrome (for example, with hepatic colic), the administration of the drug 2 times a day with an interval of 2-3 hours is possible.

The maximum duration of the drug in the form of a solution for injection is 2 days.If continuation of therapy with the drug is necessary, the parenteral form of the drug should be replaced with an oral or rectal form.

It is allowed to combine the dosage forms of the drug, but the total daily dose of diclofenac, which should not exceed 150 mg, should be considered.

In patients who receive long-term therapy with Olfen, the liver, heart and kidney function, as well as the blood picture, should be monitored regularly.

Transdermal patch

The Olfen plaster should be applied to the affected area 1-2 times a day. The skin where the product is used should be clean and dry. Do not pre-lubricate it with cream.

You need to apply the patch without stretching it. When used in the field of moving joints, for example, on elbows, it is desirable to strengthen it by means of a mesh bandage.

Before the hygienic procedures, the patch can be removed and then pasted again.

Side effect

• nausea, vomiting;
• stool disorder;
• abdominal pain, including spasticity;
• flatulence;
• indigestion;
• anorexia;
• stomatitis;
• pancreatitis;
• gastrointestinal bleeding;
• ulcerative colitis;
• hemorrhagic colitis;
• hepatitis;
• jaundice;
• headache;
• dizziness;
• disorders of cerebral circulation;
• fatigue;
• memory impairment and orientation in space;
• violation of sleep and wakefulness;
• paresthesia;
• convulsions;
• emotional lability;
• aseptic meningitis;
• impaired vision and hearing;
• noise in ears;
• change in taste;
• edema;
• kidney failure;
• the presence of blood in the urine;
• interstitial nephritis;
• necrotizing papillitis;
• nephrotic syndrome;
• heart rhythm disorder;
• cardialgia;
• increased blood pressure;
• heart failure;
• Thrombocytopenia, leukopenia, anemia, agranulocytosis;
• skin rash;
• itching;
• hives;
• Stevens-Johnson syndrome;
• Lyell's syndrome;
• eczema;
• alopecia;
• photosensitivity;
• anaphylactic shock;
• angioedema;
• pneumonia;
• vasculitis;
• exacerbation of hemorrhoids;
• when intramuscular injection of the drug may develop necrosis and abscess at the injection site.

Contraindications

• individual sensitivity to the components of the drug and other drugs of the group of non-steroidal anti-inflammatory drugs, including the aspirin triad in the anamnesis;
• peptic ulcer of the stomach and duodenum;
• ulcerative colitis;
• acute hemorrhoids;
• severe form of heart failure;
• patients with severe impairment of liver and kidney function (creatinine clearance less than 30 ml / min);
• patients with a tendency to bleeding, including patients with a risk of postoperative bleeding and patients with violations of homeostasis and hemopoiesis;
• patients receiving therapy with high doses of anticoagulants and non-narcotic analgesics;
• pregnant women in the 3rd trimester of pregnancy;
• Children under the age of 14 (due to the lack of reliable data on the safety of the drug in this age category);
• proctitis and other rectum diseases (rectal capsules).

Application in pregnancy and lactation

Olfen may be appointed in the first and second trimesters of pregnancy by the attending physician if the expected benefit to the mother is higher than the potential risks to the fetus. During pregnancy, the drug should be used in the least effective doses and for as short a time as possible. Contraindicated use of the drug in the 3rd trimester of pregnancy.

If it is necessary to use the drug during lactation it is recommended to consultwith the attending physician and decide on the interruption of breastfeeding.

Use in children

Contraindicated in children under the age of 14 (due to the lack of reliable data on the safety of the drug in this age category).

special instructions

It is used with caution for patients with porphyria, impaired renal function, dehydration, impaired coagulation, heart disease, including heart failure.

With long-term treatment, it is necessary to periodically study the formula of blood and liver function, the analysis of feces for latent blood.

Do not apply to damaged or exposed areas of the skin, in combination with an occlusive dressing; Do not get into eyes and mucous membranes.

Impact on the ability to drive vehicles and manage mechanisms

Because of the possible reduction in reaction speed, it is not recommended to drive vehicles and work with mechanisms.

Drug Interactions

The drug, when combined, increases the plasma concentrations of lithium and digoxin.

Diclofenac sodium reduces the effectiveness of diuretics and increases the risk of hyperkalemia when combined with potassium-sparing diuretics.

When the drug is used concomitantly with other drugs, a group of non-narcotic analgesics, NSAIDs, as well as glucocorticosteroids (GCS), increases the risk of side effects.

If it is necessary to simultaneously use the drug with anticoagulants, prothrombin time should be monitored on a regular basis.

The simultaneous use of alcohol and Olfen is prohibited - the risk of developing gastrointestinal bleeding is great.

The drug has almost no effect on the effectiveness of hypoglycemic agents, but there is evidence of the development of hypoglycemia and hyperglycemia in patients taking diclofenac sodium together with hypoglycemic agents.

The drug with a combined application increases the nephrotoxicity of cyclosporine and the toxic effect of methotrexate, should observe an interval of at least a day between taking diclofenac and methotrexate.

With the combined use of the drug with quinolones, seizures may develop.

Analogues of the drug Olfen

Structural analogs for the active substance:

• Artrex;
• Beliefed;
• Voltaren;
• Voltaren Emulgel;
• Diklak;
• Diklak Lipogel;
• Diklo F;
• Diklobene;
• Dicluberl;
• Diqlovit;
• Diklogen;
• Diclomax;
• Diclomelan;
• Diclonac;
• Diclonat P;
• Dicloran;
• Diclorium;
• Diclofen;
• Diclofenac;
• Diclofenac of potassium;
• Diclofenac sodium;
• Diclofenac retard;
• Diclofenaclong;
• Diclofenacol;
• Diphene;
• Dorosan;
• Naklof;
• Naklofen;
• Naklofen Duo;
• Olfen Depocaps;
• Olfen Recoctops;
• Orthophene;
• Orthofer;
• Orthoflex;
• Rapten Duo;
• Rapent Rapid;
• Revmavek;
• Redwood retard;
• Remetan;
• Sanfinak;
• SwissSet;
• TabukDi;
• Feloran;
• Feloran retard;
• Flotac.

Similar medicines:

Other medicines: