Halidorum - instructions for use, real counterparts and release form (tablets 100 mg injections in vials for intravenous or intramuscular injection) drug to treat spasms and dyskinesia in adults, children and in pregnancy. Composition and alcohol

In this article, you can read the instructions for using the drug Galidor. Comments from visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Galidor in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Galidor in the presence of existing structural analogues.Use to treat spasms and dyskinesias, kidney stones and gallbladder and colic in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Galidor - Myotropic antispasmodic with pronounced vasodilating effect. The vasodilator effect of benzyclane (the active substance of the preparation Halidor) is mainly due to its ability to block calcium channels, antiserotonin action, and to a lesser extent - with blockade of sympathetic ganglia. Benzyclane can cause a dose-dependent suppression of Na / K-dependent ATPase and platelet and erythrocyte aggregation, as well as increased erythrocyte elasticity. These effects are observed mainly in peripheral vessels, coronary arteries and cerebral vessels.

In addition, Halidor has an antispasmodic effect on the visceral musculature (GI tract, urinary tract, respiratory system).

The drug causes a slight increase in heart rate. It is also known for its weak tranquilizing effect.

Composition

Benzyclan fumarate + excipients.

Pharmacokinetics

After taking the drug inside, Galidor is absorbed from the digestive tract quickly and almost completely.Because of the "first pass" effect through the liver, the bioavailability of the drug after ingestion is 25-35%. Approximately 30-40% of the amount of bcycliklan in circulating blood is associated with plasma proteins, 30% with red blood cells, 10% with platelets; the free fraction is 20%. Metabolism is carried out in the liver, mainly along two routes: dealkylation gives a demethylated derivative, the rupture of the ester bond gives benzoic acid, which later turns into a hippuric acid. It is excreted mainly with urine in the form of inactive metabolites, but also in unchanged form (2-3%). Most metabolites (90%) are excreted unconjugated, and a small part is conjugated (approximately 50% as a conjugate with glucuronic acid).

Indications

Vascular diseases:

• peripheral vascular disease - Raynaud's disease, other diseases with acrocyanosis and spasm of blood vessels, as well as chronic obliterating diseases of the arteries;
• diseases of cerebral vessels: in complex therapy of acute and chronic cerebral ischemia.

Elimination of spasm of internal organs:

• gastrointestinal diseases - gastroenteritis of various etiology (especially infectious), infectious and inflammatory colitis, functional diseases of the large intestine, tenesmus,postoperative flatulence, cholecystitis, cholelithiasis, condition after cholecystectomy, motor disorders with dyskinesia of the sphincter of Oddi, peptic ulcer of the stomach and duodenum (as part of a combination therapy);
• urological syndromes: spasms and tenesmus of the bladder, concomitant therapy of urolithiasis (in combination with analgesics in renal colic).

Preparation for instrumental methods of research in urology.

Forms of release

Tablets of 100 mg.

Solution for intravenous and intramuscular injection (injections in ampoules for injection).

Instructions for use and dosing regimen

Vascular diseases

Inside, Halidor is prescribed 100 mg 3 times a day for 2-3 months. The maximum daily intake for oral administration is 400 mg. The interval between courses is 2-3 months.

The drug can also be used as an intravenous infusion in a daily dose of 200 mg divided into 2 injections. Before the infusion, 100 mg (4 ml) of the drug is diluted in 100-200 ml of isotonic sodium chloride solution and administered intravenously dropwise (as a dropper) for 1 hour 2 times a day.

To eliminate spasm of internal organs

Inside, Halidor is prescribed in a dose of 100-200 mg once, but not more than 400 mg per day. For maintenance therapy appoint 100 mg 3 times a day for 3-4 weeks, then 100 mg twice a day. The duration of treatment is determined individually, depending on the disappearance of the symptoms of the disease and, as a rule, does not exceed 1-2 months.

In acute cases, Halidor is administered IV slowly in a dose of 100-200 mg (4-8 ml) or intramuscularly deep at a dose of 50 mg (2 ml). Before / in the introduction of the required amount of solution is diluted with an isotonic sodium chloride solution to 10-20 ml. The course of treatment is 2-3 weeks with the subsequent transfer of the patient, if necessary, to take the drug Galidor inside.

Side effect

• dry mouth;
• abdominal pain;
• feeling of satiety;
• nausea, vomiting;
• increased hepatic transaminase activity in blood serum;
• anxiety;
• dizziness;
• headache;
• violation of gait;
• tremor;
• sleep disorders;
• insomnia;
• memory disorders;
• epileptiform seizures;
• hallucinations;
• symptoms of focal CNS lesion;
• atrial and ventricular tachyarrhythmia (especially when combined with other pro-arrhythmogenic drugs);
• general malaise;
• increase in body weight;
• leukopenia;
• allergic reactions;
• thrombophlebitis with intravenous administration.

Contraindications

• severe respiratory failure;
• severe renal failure;
• severe hepatic impairment;
• Decompensated heart failure;
• acute myocardial infarction;
• AV blockade;
• epilepsy and other forms of spasmophilia;
• recently suffered hemorrhagic stroke;
• craniocerebral trauma (during the last 12 months);
• pregnancy;
• lactation period (breastfeeding);
• children and adolescents under 18 years of age (insufficient experience of use);
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Pre-clinical data showed no embryotoxic or teratogenic effects, however, adequate and strictly controlled clinical studies on the use of the drug Halidor in pregnancy and lactation were not conducted. Therefore, the administration of the drug to patients in the first trimester of pregnancy is not recommended.

If it is necessary to use the drug during lactation, the question of stopping breastfeeding during treatment should be resolved.

Use in children

Contraindicated in children and adolescents under the age of 18 years (inadequate experience of use).

Application in elderly patients

A special dosage regimen when using the drug Galidor in elderly patients is not required.

special instructions

With the simultaneous appointment of Halidor with drugs that cause hypokalemia, cardiac glycosides, with drugs that depress myocardial function, the daily dose of Halidor should not exceed 150-200 mg.

When parenteral application should be changed place of injection, tk. the drug can cause damage to the vascular endothelium and thrombophlebitis.

It should refrain from parenteral administration of the drug to patients with severe cardiovascular or respiratory failure, predisposed to collapse, as well as prostatic hypertrophy and urinary retention (the degree of delay increases with relaxation of the bladder muscles).

With prolonged use of Halidor, a systematic (no less than 1 time in 2 months) laboratory testing of rheological blood properties is recommended.

Impact on the ability to drive vehicles and manage mechanisms

At the beginning of the course of treatment, patients should take special care when driving vehicles and other potentially hazardous activities.

Drug Interactions

With simultaneous application, Halidor enhances the oppressive effect on the central nervous system for anesthesia and sedatives, including when drinking alcohol and alcohol-containing drugs.

With the simultaneous use of Halidor with sympathomimetics, the risk of developing tachycardia, atrial and ventricular tachyarrhythmias increases.

With the simultaneous use of Halidor and drugs that lower the level of potassium in the blood (including diuretics, cardiac glycosides), and quinidine, a possible combination of pro-arrhythmic effects.

With the simultaneous use of Galidor with digitalis preparations, the risk of arrhythmia increases with an overdose of cardiac glycosides.

With the simultaneous use of Galidor with beta-blockers, it may be necessary to select a dose of beta-adrenoblocker because of the opposite of chronotropic effects (negative in beta-adrenoblockers and positive in benzyclan).

With the simultaneous use of Halidor with calcium channel blockers and other antihypertensive drugs, it is possible to enhance their effect.

With the simultaneous use of Halidor with drugs that cause side effects in the form of spasmophilia, it is possible to sum these effects.

With the simultaneous use of Halidor with acetylsalicylic acid, inhibition of platelet aggregation is possible.

Analogues of the drug Galidor

Structural analogs for the active substance:

• Benzyclan fumarate.

Analogues on the pharmacological group (myotropic antispasmodics):

• Avisan;
• Andipal;
• Dibazol;
• Dicetel;
• Drotaverine;
• Duspatalin;
• Kellin;
• Librax;
• Marelin;
• Nikoshpan;
• But the spine;
• But the forte;
• Noshpalgin;
• Novitropane;
• Nomigren;
• NoshBra;
• Oxybutine;
• Papaverine;
• Pape;
• Platyphylline;
• Spazmol;
• Spasmodic;
• Spasmonet;
• Cosporeine;
• Sparex;
• Trigan;
• Trimedate;
• Urolesan;
• Cystenal;
• Cystrin;
• Enablex;
• Yunispaz.

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