Retinoic ointment - instructions for use, reviews, analogs and formulations (ointment, cream or gel 0.01%, 0.05% and 0.1%) of the drug for the treatment of wrinkles, acne or acne, dermatitis, rosacea in adults, children and during pregnancy. Composition

In this article, you can read the instructions for using the drug Retinoic ointment. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Retinoic ointment in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Retinoevoy ointment in the presence of existing structural analogues. Use to treat wrinkles, acne or acne, dermatitis, rosacea in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Retinoic ointment - a remedy for the treatment of acne and dermatitis, reducing wrinkles. Promotes the normalization of terminal differentiation of cells, inhibits the hyperproliferation of the epithelium of the excretory ducts of the sebaceous glands, the formation of detritus and facilitates its evacuation. Due to this, the production of sebum decreases, its isolation is facilitated, the composition is normalized, the inflammatory reaction around the glands is reduced. With external and systemic application it has antiseboric, sebostatic, anti-inflammatory, kerato-and immunomodulatory effects; strengthens the regeneration processes in the skin.

Composition

Isotretinoin + auxiliary substances.

Pharmacokinetics

After ingestion isotretinoin absorbed from the gastrointestinal tract, absorption can increase when taken with food. Cmax in the blood plasma is achieved 1-4 hours after ingestion. Bioavailability during ingestion is low, which may be due to parietal metabolism in the intestinal wall and the effect of "first passage" through the liver. Isotretinoin binds to a high degree of plasma proteins. Metabolised in the liver with the formation of the main metabolite of 4-oxo-isotretinoin, there is also some isomerization of isotretinoin to tretinoin.Isotretinoin, Tretinoin and its metabolites undergo enterohepatic recirculation. An equivalent amount is determined in the feces, mainly in unchanged form, and in urine in the form of metabolites.

Indications

For oral administration: severe forms of nodular-cystic acne, especially with localization on the trunk.

For rectal administration: severe recurrent forms of acne, rash with concomitant seborrheic process.

For external use: papulo-pustular acne, seborrhea, rosacea, perioral dermatitis.

In cosmetology: to reduce wrinkles, excessive skin pigmentation.

Forms of release

Ointment for external use 0,01%, 0,05% and 0,1% (sometimes the cream or gel is mistakenly called).

Instructions for use and how to use them

For oral administration, the initial dose is 500 mcg / kg per day; the maximum daily dose is applied for a limited time and is 1 mg / kg; maintenance dose - 0.1-1 mg / kg per day; duration of treatment - 16 weeks, repeated course is carried out with an interval of 8 days. Take with food in 1 or more receptions.

Rectal - 0.5-1 mg / kg once a day at night (in the supine position); course of treatment - 8-12 weeks, intervals between courses - 1-2 months.

Ointment is applied a thin layer on the affected skin 2 times a day. Duration of treatment is 4-6 weeks.

Side effect

• dryness of mucous membranes;
• skin rash;
• dermatitis;
• itching;
• cheilitis;
• erythema (especially on the face);
• sweating;
• palmar-plantar peeling;
• paronychia;
• nail dystrophy;
• increased proliferation of granulation tissue in the affected area;
• thinning hair;
• vasculitis;
• photosensitivity;
• conjunctivitis;
• photophobia;
• decreased night vision;
• corneal opacity;
• hearing impairment;
• headache;
• depression;
• convulsive seizures;
• propensity to suicide;
• intracranial hypertension;
• nausea;
• colitis;
• bleeding from the digestive tract;
• hepatitis;
• anemia;
• neutropenia;
• change in the number of platelets;
• increased ESR;
• pain in muscles and joints;
• nose bleed.

Contraindications

• Pregnancy, established and planned;
• lactation;
• hypersensitivity to isotretinoin;
• simultaneous use of antibiotics of the tetracycline group;
• severe dysfunction of the liver and / or kidney;
• hypervitaminosis A;
• significantly elevated lipid levels in blood plasma;
• neoplasms;
• diseases of the rectum (for rectal use).

Application in pregnancy and lactation

Retinoic ointment has a pronounced teratogenic and embryotoxic effect.

Contraindicated with an established and planned pregnancy.

Contraindicated during lactation.

Use in children

Safety of use in children and patients of prepubescent age under 18 years is not established.

special instructions

Rectally and externally apply with caution in diseases of the liver, kidneys, chronic pancreatitis, cardiac decompensation, chronic intoxications (including alcohol).

When rectal and external application with a sharp reaction of exacerbation in the form of new rashes, itching, puffiness and redness of the skin (at the 1-2 nd week of treatment), it is recommended to cancel the treatment for a few days before it subsides, then the therapy can be resumed.

When ingestion, regular monitoring of liver function and lipid levels in the blood plasma is necessary before treatment, 1 month after the start of therapy, and then every 3 months.

With diabetes, obesity, alcoholism or lipid metabolism disorders, more frequent monitoring of laboratory parameters is recommended.When diabetes mellitus or suspected of it, you need to strictly monitor the level of glucose in the plasma.

With prolonged use, it is possible to develop symptoms of chronic hypervitaminosis A.

During the treatment period or for some time after its termination, it is impossible to be donors for women of childbearing age.

On the background of therapy, patients should not be prescribed UV-therapy, patients should avoid direct exposure to sunlight.

During treatment, contact lens intolerance may occur.

The active substance retinoic ointment - isotretinoin, and especially the product of its metabolism in the human body - tretinoin, help fight aging skin and wrinkles, photosensitization, increased skin pigmentation. Isotretinoin normalizes the keratinization of skin cells, influences the process of creation and restoration of intercellular substance containing collagen and elastin threads.

It should avoid simultaneous use of isotretinoin and derivatives of 19-nortestosterone, especially in patients with gynecological / endocrine diseases.

It is not recommended the simultaneous use of other drugs,possessing keratolytic or exfoliative properties (including other retinoids), as well as Progesterone in microdoses (including mini-pills preparations).

Drug Interactions

The effect of isotretinoin is weakened by the simultaneous use of progesterone in microdoses.

With simultaneous application of retinoic ointment and vitamin A, toxic effects can be increased.

With the simultaneous use of isotretinoin and antibiotics of the aminoglycoside group, there is a risk of developing intracranial hypertension.

Analogues of the drug Retinoic ointment

Structural analogs for the active substance:

• 13-cis-Retinoic acid;
• Acnekutan;
• Verocutan;
• Isotretinoin;
• Retasol;
• Roaccutane;
• Wipe off.

Analogues on the curative effect (remedies for wrinkles):

• Corff;
• Xeomin;
• Egalohit.

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