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Baclofen - instructions for use, analogs, testimonials and release forms (10 mg and 25 mg tablets) for the treatment of muscle cramps and spasms in cerebral palsy and spinal cord diseases in adults, children and pregnancy. Composition

Baclofen - instructions for use, analogs, testimonials and release forms (10 mg and 25 mg tablets) for the treatment of muscle cramps and spasms in cerebral palsy and spinal cord diseases in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Baclofen. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Baclofen in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Baclofen in the presence of existing structural analogues. Use for the treatment of muscle cramps and spasms in cerebral palsy and spinal cord diseases in adults, children, as well as in pregnancy and lactation. Composition of the preparation.

 

Baclofen - Muscle relaxant of central action; agonist of GABA receptors. Oppresses mono- and polysynaptic reflexes, apparently due to a decrease in the excretion of excitatory amino acids (glutamate and aspartate) from the terminals, which occurs as a result of stimulation of presynaptic GABA-receptors. Does not affect the transfer of impulses in neuromuscular synapses. Reduces the tone of skeletal muscles. Has a moderate analgesic effect.

 

Composition

 

Baclofen + auxiliary substances.

 

Pharmacokinetics

 

After oral administration, Baclofen is quickly and completely absorbed from the digestive tract. Binding to plasma proteins is about 30%. Baclofen penetrates the placental barrier, excreted in breast milk. Metabolised in the liver. It is excreted in the urine, mostly unchanged.

 

Indications

  • spasticity of skeletal muscles in multiple sclerosis;
  • spastic conditions in diseases of the spinal cord of infectious, degenerative, traumatic genesis, as well as in children's cerebral palsy (cerebral palsy).

 

Forms of release

 

Tablets 10 mg and 25 mg.

 

Instructions for use and dosage

 

Inside with food, adults at the beginning of treatment - 5 mg 3 times a day.For every 4th day of treatment, the dose is increased by 5 mg 3 times a day until the optimal therapeutic effect develops. The average daily dose is 30-75 mg, if necessary, it can be increased to 100-120 mg. The final daily dose is set individually so that along with the weakening of the clonus and muscle spasm, the tonus of muscles sufficient to carry out active movements is maintained.

 

For patients with increased susceptibility to drugs, the initial daily dose may be 5-10 mg, followed by a slower increase. For patients with renal insufficiency, as well as hemodialysis, the daily dose is 5 mg.

 

For children under 10 years, the daily dose is 0.75-2 mg / kg, over 10 years - 2.5 mg / kg. Treatment begins with a dose of 2.5 mg 4 times a day. The daily dose, as well as in adults, is selected individually, increasing it every 3 days, in accordance with the clinical course of the disease. The maintenance dose for children aged 1-2 years is 10-20 mg per day, for children aged 2-10 years, 30-60 mg per day.

 

Side effect

  • drowsiness;
  • dizziness (especially at the beginning of treatment);
  • apathy;
  • feeling tired;
  • sleep disorders;
  • confusion of consciousness;
  • euphoria;
  • depression;
  • paresthesia;
  • myalgia;
  • muscle weakness;
  • ataxia;
  • tremor;
  • nystagmus;
  • violations of accommodation;
  • hallucinations;
  • there may be an increase in seizures and a decrease in the threshold of their occurrence (especially with epilepsy);
  • nausea;
  • dry mouth;
  • constipation, diarrhea;
  • impaired liver function;
  • arterial hypotension;
  • deterioration of the cardiovascular system;
  • respiratory depression;
  • enuresis.

 

Contraindications

  • epilepsy;
  • convulsions (in the anamnesis);
  • Parkinson's disease;
  • psychoses;
  • chronic renal failure;
  • pregnancy;
  • lactation period;
  • hypersensitivity to baclofen.

 

Application in pregnancy and lactation

 

Baclofen is contraindicated in pregnancy (effects on the fetus are not established).

 

For the duration of treatment, breastfeeding should be discontinued.

 

Use in children

 

For children under 10 years, the daily dose is 0.75-2 mg / kg, over 10 years - 2.5 mg / kg. Treatment begins with a dose of 2.5 mg 4 times a day. The daily dose, as well as in adults, is selected individually, increasing it every 3 days, in accordance with the clinical course of the disease.The maintenance dose for children aged 1-2 years is 10-20 mg per day, for children aged 2-10 years, 30-60 mg per day.

 

Application in elderly patients

 

Use with caution in elderly patients.

 

special instructions

 

Side effects often have a transitory character, they can disappear or decrease with decreasing dose. The need for interruption of therapy is rare. Side effects of baclofen should be distinguished from the symptoms of the disease, for which treatment is being administered. Abolition of baclofen should be carried out gradually, reducing the dose within 1-2 weeks (except in cases of serious side effects).

 

They are used with caution in cerebrovascular disorders, psychotic conditions, schizophrenia, peptic ulcer and duodenal ulcer, respiratory disorders, liver and kidney function disorders, and in elderly patients. With concomitant epilepsy, treatment should be performed under strict medical supervision and without interruption of adequate therapy with anticonvulsants. In patients with dysuria, against the background of treatment with baclofen, hypertension of the sphincter of the bladder and urinary retention may be observed.In patients with liver diseases and diabetes mellitus, the level of hepatic transaminases, alkaline phosphatase and blood sugar should be periodically monitored.

 

Refers to a special form of accounting and is released only on prescription, as it can cause a dependence similar to narcotic. Selection of an individual daily dose is recommended in a hospital.

 

Impact on the ability to drive vehicles and manage mechanisms

 

During treatment should be refrained from potentially dangerous activities requiring increased attention and rapid psychomotor reactions.

 

Drug Interactions

 

With the simultaneous use of baclofen increases the effect of antihypertensive drugs, ethanol (alcohol).

 

With simultaneous use with tricyclic antidepressants, a significant decrease in muscle tone is possible.

 

A case of toxic reactions caused by the action of baclofen (disturbance of consciousness, disorientation, bradycardia, blurred vision, hypotension, hypothermia), while the use of Ibuprofen in elderly patients with impaired renal function.

 

With simultaneous use with lithium preparations, severe manifestations of hyperkinetic symptoms are possible.

 

In patients with Parkinson's disease, with simultaneous application of baclofen with levodopa and carbidopa, hallucinations, confusion, and arousal can occur.

 

Analogues of the drug Baclofen

 

Structural analogs for the active substance:

  • Baclosan;
  • Liorasal Intrathecal.

 

Analogues on the curative effect (remedies for the treatment of multiple sclerosis):

  • Avonex;
  • Alfaron;
  • Baclosan;
  • Betaferon;
  • Gilenia;
  • Dimephosphone;
  • Durogesic;
  • Carbamazepine;
  • Carbapine;
  • Copakson Teva;
  • Layfferon;
  • Lemodus;
  • Metovit;
  • Midokalm;
  • Neovir;
  • Parcón;
  • Polcortolone;
  • Prednisolone;
  • EU Reaferon;
  • Rebif;
  • Ronbetal;
  • Sirdalud;
  • Tizanil;
  • Phenotropil;
  • Finlepsin;
  • Finlepsin retard;
  • Phlogenzyme;
  • Cyanocobalamin (Vitamin B12);
  • Extavia.

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