Ketanov - instructions for use, real counterparts and release form (tablets 10 mg injections in vials for injection) drugs for the treatment of pain (headache, toothache, menstrual) in adults, children and in pregnancy

In this article, you can read the instructions for using the drug Ketanov. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Ketanov in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ketanov with available structural analogues. Use for the treatment of pain (headache, dental, when menstruating) in adults, children, as well as during pregnancy and lactation.The mechanism of analgesic effect.

Ketanov - a non-steroidal anti-inflammatory agent, a pyrrolizine-carboxylic acid derivative. It has a pronounced analgesic effect, has also an anti-inflammatory and moderate antipyretic effect. The mechanism of action is associated with oppression of the activity of COX, the main enzyme of arachidonic acid metabolism, which is the precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The active substance of the drug is Ketorolac.

Pharmacokinetics

When ingested absorbed from the gastrointestinal tract. Eating does not affect absorption. More than 90% of the dose is excreted in the urine, in unchanged form - 60%; The rest is through the intestines.

Indications

• for short-term relief of moderate and severe pain of various genesis.

Forms of release

The tablets covered with a cover of 10 mg.

Solution for intramuscular injection (injections in ampoules for injection) 30 mg / ml.

Other forms of the drug (whether candles or suspension) are either counterfeits of the original drug, or other forms and trade names of the active substance Ketorolac.

Instructions for use and dosing regimen

Adults with oral administration - 10 mg every 4-6 hours, if necessary - 20 mg 3-4 times a day.

With intramuscular injection, a single dose of 10-30 mg, the interval between administrations is 4-6 hours. The maximum duration of application is 2 times a day.

Maximum doses: when ingestion or intramuscular injection - 90 mg per day; for patients with a body weight of up to 50 kg, with violations of kidney function, as well as for people over 65 years - 60 mg per day.

Side effect

• bradycardia;
• changes in blood pressure;
• palpitation;
• fainting;
• nausea;
• stomach ache;
• diarrhea;
• constipation;
• flatulence;
• feeling of overflow of the gastrointestinal tract;
• vomiting;
• dry mouth;
• thirst;
• stomatitis;
• gastritis;
• erosive and ulcerative lesions of the gastrointestinal tract;
• anxiety;
• headache;
• drowsiness;
• depression;
• euphoria;
• sleep disorders;
• dizziness;
• change in taste;
• attacks of suffocation;
• increased frequency of urination;
• nasal bleeding;
• Anemia, eosinophilia, thrombocytopenia;
• increased sweating;
• edema;
• hypokalemia, hyponatremia;
• itching;
• hemorrhagic rash;
• exfoliative dermatitis;
• hives;
• Lyell's syndrome;
• Stevens-Johnson syndrome;
• anaphylactic shock;
• bronchospasm;
• angioedema;
• fever;
• pain at the injection site.

Contraindications

• erosive and ulcerative lesions of the gastrointestinal tract in the phase of exacerbation;
• presence or suspicion of gastrointestinal bleeding and / or craniocerebral hemorrhage;
• blood clotting disorders in the anamnesis;
• a condition with a high risk of bleeding or incomplete hemostasis;
• hemorrhagic diathesis;
• moderate and severe renal dysfunction (serum creatinine content more than 50 mg / l);
• risk of developing renal failure in hypovolemia and dehydration;
• "aspirin triad";
• bronchial asthma;
• polyps of the nasal cavity;
• angioedema in history;
• preventive anesthesia before surgery and during surgery;
• children and adolescents under 16;
• pregnancy;
• childbirth;
• lactation;
• increased sensitivity to ketorolac, acetylsalicylic acid and other NSAIDs.

Application in pregnancy and lactation

Contraindicated in pregnancy, during labor and during lactation (breastfeeding).

Ketanov is contraindicated for use as a means for premedication, supporting anesthesia and for anesthesia in obstetric practice, since under its influence it is possible to increase the duration of the first period of labor.In addition, Ketorolac can inhibit uterine contractility and fetal circulation.

special instructions

They are used with caution in patients with impaired liver and kidney function, chronic heart failure, arterial hypertension, in patients with erosive and ulcerative gastrointestinal lesions and bleeding from the gastrointestinal tract in anamnesis.

Caetanov should be used with caution in the postoperative period in cases when particularly careful hemostasis is required (including after resection of the prostate, tonsillectomy, in cosmetic surgery), as well as in senile patients. the half-life of ketorolac is prolonged, and plasma clearance may decrease. In this category of patients it is recommended to use ketorolac in doses close to the lower limit of the therapeutic range. If there are symptoms of liver damage, skin rash, eosinophilia, ketorolac should be discarded. Ketorolac is not indicated for use in chronic pain syndrome.

Impact on the ability to drive vehicles and manage mechanisms

If during the treatment with ketorolac there are drowsiness, dizziness,insomnia or depression, special care must be taken during occupations with potentially dangerous activities requiring increased attention and speed of psychomotor reactions.

When taken concomitantly with ethanol (alcohol), it can cause bleeding from the gastrointestinal tract.

Drug Interactions

With the simultaneous use of Ketanov with other NSAIDs, it is possible to develop additive side effects; with pentoksifillinom, anticoagulants (including Heparin in low doses) - may increase the risk of bleeding; with ACE inhibitors - there may be an increased risk of kidney dysfunction; with probenecid - the concentration of ketorolac in the plasma and its half-life increase; with lithium preparations - it is possible to reduce renal clearance of lithium and increase its concentration in plasma; with Furosemide - a decrease in its diuretic effect.

When ketorolac is used, the need for opioid analgesics for analgesia is reduced.

Analogues of the drug Ketanov

Structural analogs for the active substance:

• Adolor;
• Akyular;
• Dolak;
• Dolomin;
• Ketalgin;
• Ketolac;
• Ketorol;
• Ketorolac;
• Ketorolac Rhompharm;
• Ketorolac-OBL;
• Ketorolak-Eskom;
• Ketorolac tromethamine;
• Ketofril;
• Thoradol;
• Torolac.

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