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Humalog - instructions for use, analogs, reviews and release forms (syringe handle KvikPen with solution or suspension Mix 25 and 50 insulin) drug for the treatment of type 1 and type 2 diabetes in adults, children and pregnancy. Composition

Humalog - instructions for use, analogs, reviews and release forms (syringe handle KvikPen with solution or suspension Mix 25 and 50 insulin) drug for the treatment of type 1 and type 2 diabetes in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Humalog. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Humalog in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Humalog in the presence of existing structural analogues.Use for the treatment of type 1 and type 2 diabetes (insulin-dependent and non-insulin-dependent diabetes) in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

 

Humalog - an analog of human insulin, differs from it by an inverse sequence of proline and lysine amino acid residues at positions 28 and 29 of the B chain of insulin. Compared with short-acting insulin preparations for insulin, lyspro is characterized by a faster onset and end effect, which is due to increased absorption from the subcutaneous depot due to the preservation in the solution of the monomeric structure of insulin molecules, lyspro. The onset of action is 15 minutes after subcutaneous injection, the maximum effect is between 0.5 h and 2.5 h; duration of action - 3-4 hours.

 

Humalog Mix is ​​a DNA-recombinant analog of human insulin and is a ready-made mixture consisting of insulin lispro solution (high-speed analog of human insulin) and insulin suspension of lispro protamine (an analog of human insulin of average duration of action).

 

The main effect of insulin lispro is the regulation of glucose metabolism.In addition, it has anabolic and anti-catabolic effect on various tissues of the body. In muscle tissue, the content of glycogen, fatty acids, glycerol increases, protein synthesis increases and amino acid consumption increases, but glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, protein catabolism and amino acid release decrease.

 

Composition

 

Insulin lyspro + auxiliary substances.

 

Pharmacokinetics

 

Completeness of absorption and the beginning of the effect of insulin depends on the place of administration (abdomen, thigh, buttocks), the dose (volume of insulin administered), the concentration of insulin in the preparation. It is distributed unevenly in the tissues. It does not penetrate the placental barrier and into breast milk. It is destroyed by insulinase mainly in the liver and kidneys. It is excreted by the kidneys - 30-80%.

 

Indications

  • Type 1 diabetes mellitus (insulin-dependent), incl. with intolerance to other insulin preparations, with postprandial hyperglycemia, which can not be corrected by other insulin preparations, acute subcutaneous insulin resistance (accelerated local insulin degradation);
  • Type 2 diabetes mellitus (non-insulin-dependent): with resistance to oral hypoglycemicdrugs, as well as in violation of absorption of other insulin preparations, uncorrectable postprandial hyperglycemia, in operations, intercurrent diseases.

 

Forms of release

 

Solution for intravenous and subcutaneous injection of 100 IU in a 3 ml cartridge, embedded in a pen syringe or Penicom Pen.

 

Suspension for subcutaneous administration of 100 IU in a 3 ml cartridge, embedded in a pen syringe or Penichen foam (Humalog Mix 25 and 50).

 

There are no other dosage forms, be it pills or capsules.

 

Instructions for use and how to use them

 

Humalog

 

Dosage is set individually. Insulin Lyspro is administered subcutaneously, intramuscularly or intravenously 5-15 minutes before meals. Single dose is 40 units, excess is allowed only in exceptional cases. With monotherapy, insulin lizpro is administered 4-6 times a day, in combination with prolonged insulin preparations - 3 times a day.

 

Humalog Mix

 

The drug should be administered subcutaneously.

 

Intravenous introduction of the preparation Humalog Mix is ​​contraindicated.

 

The temperature of the drug should be at room temperature.

 

Subcutaneously should be administered to the shoulder, hips, buttocks or abdomen.The injection sites should be alternated in such a way that one and the same place is used no more than once a month. When n / to the introduction of the drug Humalog, care must be taken to avoid getting the drug into the blood vessel. After injection, do not massage the injection site.

 

When inserting the cartridge into the insulin delivery device and attaching the needle before introducing insulin, the instructions of the manufacturer of the insulin delivery device should be strictly followed.

 

Rules for the administration of Humalog Mix

 

Preparation for introduction

 

Immediately prior to use, the Humalog Mix cartridge should be rolled between the palms ten times and shaken, turning 180 ° also ten times to resuspend insulin until it becomes a homogeneous cloudy liquid or milk. Do not shake vigorously. this can lead to the appearance of foam, which can interfere with the correct dose set. To facilitate mixing, the cartridge contains a small glass bead. The drug is not to be used if it has flakes after mixing.

 

How to administer the drug

  1. Wash the hands.
  2. Choose a place for injection.
  3. Treat the skin with an antiseptic at the injection site (with self-injection - in accordance with the doctor's recommendations).
  4. Remove the outer protective cap from the needle.
  5. Fix the skin by pulling it or by pinching a large crease.
  6. Insert the needle subcutaneously and perform the injection in accordance with the instructions for using the syringe pen.
  7. Remove the needle and gently squeeze the injection site for a few seconds. Do not rub the injection site.
  8. Using the outer protective cap of the needle, unscrew the needle and destroy it.
  9. Put the cap on the syringe pen.

 

Side effect

  • hypoglycemia (severe hypoglycemia can lead to loss of consciousness and, in exceptional cases, death);
  • redness, swelling, or itching at the injection site (usually disappear within a few days or weeks, in some cases these reactions may be caused by causes not associated with insulin, for example, skin irritation with an antiseptic or improper injection);
  • generalized itching;
  • difficulty breathing;
  • dyspnea;
  • a decrease in blood pressure;
  • tachycardia;
  • increased sweating;
  • development of lipodystrophy at the injection site.

 

Contraindications

  • hypoglycemia;
  • hypersensitivity to the components of the drug.

 

Application in pregnancy and lactation

 

To date, no undesirable effect of insulin lyspro on pregnancy or the condition of the fetus and newborn has been identified.

 

The purpose of insulin therapy in pregnancy is to maintain adequate glucose control. The need for insulin usually decreases in 1 trimester and increases in the 2nd and 3rd trimester of pregnancy. During and immediately after delivery, the need for insulin can dramatically decrease.

 

Women of childbearing age, suffering from diabetes, should inform the doctor about the coming or planned pregnancy.

 

Patients with diabetes mellitus during breastfeeding may need to adjust the dose of insulin and / or diet.

 

special instructions

 

The method of administration intended for the used dosage form of insulin lispro is to be strictly observed. When transferring patients from fast-acting insulin preparations of animal origin to insulin, lyspro may require dose adjustment. Transfer of patients receiving insulin in a daily dose exceeding 100 units from one type of insulin to another is recommended to be performed in a hospital.

 

The need for insulin can increase during an infectious disease, with emotional stress, with an increase in the amount of carbohydrates in the diet, during additional intake of drugs with hyperglycemic activity (thyroid hormones, glucocorticoids, oral contraceptives, thiazide diuretics).

 

The need for insulin can decrease with renal and / or liver failure, with a decrease in the amount of carbohydrates in food, with increased physical activity, during additional intake of drugs with hypoglycemic activity (MAO inhibitors, nonselective beta-blockers, sulfonamides).

 

Correction of hypoglycemia in a relatively acute form can be performed with the aid of an / m and / or a / c injection of glucagon or intravenous glucose.

 

Drug Interactions

 

The hypoglycemic effect of insulin lizpro is enhanced by MAO inhibitors, nonselective beta adrenoblockers, sulfonamides, acarbose, ethanol (alcohol), and ethanol-containing drugs.

 

Hypoglycemic effect of insulin lizpro reduce glucocorticosteroids (GCS), thyroid hormones, oral contraceptives, thiazide diuretics, diazoxide, tricyclic antidepressants.

 

Beta-blockers, clonidine, reserpine can mask the manifestation of symptoms of hypoglycemia.

 

Analogues of the drug Humalog

 

Structural analogs for the active substance:

  • Insulin lyspro;
  • Humalog Mix 25;
  • Humalog Mix 50.

 

Analogues for the pharmacological group (insulin):

  • Actrapid HM Penfill;
  • Actrapid MS;
  • B-Insulin S.Ts. Berlin-Chemie;
  • Bersulinulin H 30/70 U-40;
  • Bersulinulin H 30/70 Pen;
  • Berlinululin N Basal U-40;
  • Berlinersulin H Basal Pen;
  • Berinsulin N Normal U-40;
  • Berensulin H Normal Foam;
  • Depo insulin C;
  • Isofan Insulin World Cup;
  • Iletin;
  • Insulin Lente SPP;
  • Insulin C;
  • Insulin pork high-purity MK;
  • Insuman Comb;
  • Inutral SPP;
  • Inutral CHM;
  • Combinsulin C;
  • Mixtard 30 NM Penfill;
  • Monosuansulin MK;
  • Monotard;
  • Pensulin;
  • Protafan HM Penfill;
  • Protafan MS;
  • Rinsulin;
  • Ultradard NM;
  • Homolong 40;
  • Homorap 40;
  • Khumulin.

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Reviews (2):
Guests
Asiyat
Good morning. Tell me, please, is it possible to replace humulin m3 by humalog?
Administrators
admin
AsiyatTo answer this question, you need to know the entire history of your illness and the reasons for which you think this replacement is necessary. Both drugs are quite effective insulin analogues. Khumulin - the average duration of the duration, Humalog - a short insulin. I think to solve this issue you better go to your endocrinologist.

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