Remantadin - instructions for use, reviews, analogs and form of release (50 mg tablets) for the treatment and prevention of influenza in adults, children and pregnancy
In this article, you can read the instructions for using the drug Remantadine. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Remantadine in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Remantadine in the presence of existing structural analogues. Use for the treatment and prevention of influenza in adults, children, as well as during pregnancy and lactation.
Remantadine antiviral agent, adamantane derivative.The main mechanism of antiviral action is the inhibition of the early stage of specific reproduction after the virus enters the cell and before the initial transcription of RNA. Pharmacological effectiveness is provided by inhibiting the reproduction of the virus in the initial stage of the infectious process.
It is active against various strains of influenza A virus (especially A2 type), as well as viruses of tick-borne encephalitis (central European and Russian spring-summer), which belong to the group of arboviruses of the Flaviviridae family.
Composition
Rimantadine hydrochloride + excipients.
Pharmacokinetics
After ingestion slowly, almost completely absorbed in the intestine. Concentration in nasal secretion is 50% higher than plasma concentration. Metabolised in the liver. It is excreted by the kidneys (15% in unchanged form, 20% in the form of hydroxyl metabolites).
Indications
- prevention and early treatment of influenza in adults and children older than 7 years;
- prevention of influenza in the period of epidemics in adults;
- prevention of tick-borne encephalitis of viral etiology.
Forms of release
Tablets 50 mg.
Other medicinal forms of the drug, including syrup or capsules, do not exist, perhaps these drugs are fakes.
Instructions for use and dosage
Inside, after eating, on the 1st day - 100 mg 3 times (or 300 mg once), on the 2 nd and 3 rd day - 100 mg 2 times, on the 4 th day - 100 mg 1 time; children from 7 to 10 years - 50 mg 2 times a day, 11 to 14 years - 3 times a day. Course - 5 days.
As a preventive agent - 50 mg once a day for 10-15 days.
After bite of encephalitic tick - 100 mg 2 times a day within the next 72 hours.
Side effect
- pain in epigastrium;
- flatulence;
- increased levels of bilirubin in the blood;
- dry mouth;
- anorexia;
- nausea, vomiting;
- headache;
- insomnia;
- nervousness;
- dizziness;
- violation of concentration of attention;
- drowsiness;
- anxiety;
- increased excitability;
- fatigue;
- allergic reactions.
Contraindications
- acute liver disease;
- acute and chronic kidney disease;
- thyrotoxicosis;
- pregnancy;
- children's age till 7 years;
- increased sensitivity to rimantadine (active ingredient of Remantadine).
Application in pregnancy and lactation
Contraindicated in pregnancy.
special instructions
With caution apply rimantadine in arterial hypertension, epilepsy (including in the anamnesis), atherosclerosis of cerebral vessels.
With the use of rimantadine, an exacerbation of chronic comorbidity may occur. In elderly patients with hypertension, the risk of hemorrhagic stroke increases. With a history of epilepsy and anticonvulsant therapy, the risk of epileptic seizure increases with rimantadine. In such cases, rimantadine is used at a dose of up to 100 mg per day concomitantly with anticonvulsant therapy.
With influenza caused by virus B, Remantadin has an antitoxic effect.
Joint reception with alcohol is not recommended. Possible development of complications from the liver, including liver failure.
Prophylactic reception is effective at contacts with the sick, with the spread of infection in closed collectives and at a high risk of the disease during the flu epidemic. Perhaps the emergence of drug-resistant viruses.
Drug Interactions
With simultaneous application of rimantadine reduces the effectiveness of antiepileptic drugs.
Adsorbents, astringents and enveloping agents reduce the absorption of Remantadine.
Means, acidifying urine (ammonium chloride, ascorbic acid), reduce the effectiveness of rimantadine (due to increased its excretion by the kidneys).
Means, alkalizing urine (acetazolamide, sodium bicarbonate) enhance its effectiveness (decreased excretion by the kidneys).
Cimetidine reduces the clearance of rimantadine by 18%.
Analogues of Remantadine
Structural analogues for the active substance (also added preparations of a similar antiviral focus):
- Algiers;
- Amiksin (a similar effect);
- Arbidol (a similar effect);
- Inhavirin (a similar effect);
- Kagocel (a similar effect);
- Orvire;
- Rimantadine;
- Rimantadine Aktitab;
- Rimantadine-STI;
- Rimantadine hydrochloride.
Similar medicines:
Other medicines:
- Cortexin - instructions for use, analogs, reviews and release forms (injections in injections (lyophilizate) 5 mg and 10 mg) drug for the treatment of encephalopathy in adults, children (including newborns) and pregnancy
- Xenical - instructions for use, analogs, reviews and release forms (capsules 120 mg) drugs to treat obesity and weight loss in adults, children and pregnancy. Composition
- Analgin - instructions for use, analogs, reviews and release forms (500 mg tablets, 100 mg suppositories, injections for injections) for the treatment of pain and temperature in adults, children and pregnancy