Butadion - instructions, reviews, analogues
In this article, you can read the instructions for using the drug Butadione. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Butad in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Butadione in the presence of existing structural analogs. Use for the treatment of arthritis, sciatica and lumbulgia in adults, children, as well as during pregnancy and lactation. Composition of the preparation.
Butadione - non-steroidal anti-inflammatory drug (NSAID), has anti-inflammatory and analgesic effect.Indiscriminately inhibits the activity of cyclooxygenases (COX-1 and COX-2) and inhibits the synthesis of prostaglandins.
Phenylbutazone (active ingredient of Butadion) inhibits the synthesis of ATP-dependent mucopolysaccharides.
Butadion is used to eliminate the pain syndrome and reduce the swelling associated with the inflammatory process. When topical application causes weakening or disappearance of pain in joints at rest and during movement. Reduces the morning stiffness and swelling of the joints, contributes to an increase in the volume of movements.
Composition
Phenylbutazone + auxiliary substances.
Pharmacokinetics
When ingestion has a high degree of absorption, bioavailability is 85-90% and decreases with long-term admission. At application system absorption does not exceed 5%. The connection with plasma proteins is more than 95%. Metabolized in the liver with the formation of two major metabolites. It is excreted by the kidneys 70% (5% unchanged), 30% - through the intestines in the form of metabolites.
Indications
- rheumatism;
- infectious nonspecific polyarthritis;
- Bechterew's disease;
- gouty arthritis;
- psoriatic arthritis;
- erythema nodosum;
- chorea;
- dermatitis;
- Burns 1 and 2 degrees of small area;
- sunburn;
- insect bites;
- inflammatory infiltrates;
- stretching of muscles and tendons;
- rheumatoid arthritis;
- arthrosis;
- synovitis;
- lumbago;
- sciatica;
- osteochondrosis;
- pain syndrome and puffiness associated with diseases of the muscles and joints.
Forms of release
Ointment for external use 5% (sometimes mistakenly called cream or gel).
Tablets 150 mg (Butadione OBL).
Other dosage forms, whether candles or injections in ampoules for injection, at the time of publication of the drug in the Directory did not exist.
Instructions for use and dosing regimen
Ointment
Outwardly.
Adults and children over the age of 14: the drug is applied in a thin layer, a strip 2-3 cm above the focus of inflammation without rubbing 2-3 times a day. The course of treatment is 7-10 days. After 10 days of use, consult a physician.
Elderly patients: there is no need for a special mode of administration.
Pills
Inside apply 150-300 mg 3-4 times a day. After clinical improvement, the dose is gradually reduced.
Side effect
- eczema;
- photosensitization;
- contact dermatitis (itching, redness, swelling of the treated skin area);
- papules, vesicles;
- peeling;
- hives;
- angioedema;
- bronchospasm;
- generalized skin rash;
- dyspepsia;
- NSAID-gastropathy;
- abdominal pain;
- nausea, vomiting;
- heartburn;
- diarrhea or constipation;
- ulceration of the mucosa of the gastrointestinal tract;
- aphthous stomatitis;
- glossitis;
- erosive esophagitis;
- bleeding (gastrointestinal, gingival, hemorrhoidal);
- abnormal liver function;
- increased blood pressure;
- heart failure;
- tachycardia;
- headache;
- dizziness;
- drowsiness;
- depression;
- excitation;
- hearing loss;
- noise in ears;
- agranulocytosis, leukopenia, anemia, thrombocytopenia.
Contraindications
- data on an attack of bronchial obstruction, allergic rhinitis, hives after taking acetylsalicylic acid or another NSAID in history;
- 1 and 3 trimesters of pregnancy (for ointment), throughout pregnancy (for tablets);
- the period of breastfeeding;
- violation of the integrity of the skin at the site of the intended application;
- children under 14 years of age (for ointment);
- joint use with other drugs containing phenylbutazone;
- hypersensitivity to phenylbutazone or other components of the drug, to acetylsalicylic acid and other NSAIDs.
Application in pregnancy and lactation
Butadione in the form of an ointment is contraindicated in 1 and 3 trimesters of pregnancy because of the possibility of impaired fetal development. In the 2nd trimester of pregnancy, Butadione is only possible if the intended benefit to the mother exceeds the potential risk to the fetus. If it is necessary to use the drug during lactation it is recommended to stop breastfeeding.
For ingestion, pregnancy is a contraindication.
Use in children
The drug in the form of an ointment is contraindicated for use in children under the age of 14 years. For tablets, the age of application of the drug is not specified.
special instructions
With systemic use of phenylbutazone, as well as with the long-term use of ointment on a damp, epithelial skin, systematic monitoring of the blood picture is necessary.
If skin reddening occurs, therapy should be discontinued.
Ointment should be applied only to intact skin, avoiding getting on open wounds. After applying, do not apply an occlusive dressing. Do not allow the drug to enter the eyes and mucous membranes.
The drug should not be used to treat deep vein thrombophlebitis of the extremities. To prevent photosensitivity, protect the skin from direct sunlight. When combined with other dosage forms of Butadione, the maximum daily dose of this drug should be taken into account.
Impact on the ability to drive vehicles and manage mechanisms
During treatment, one should refrain from engaging in potentially dangerous activities that require increased attention and speed of mental and motor reactions.
Drug Interactions
With simultaneous use with anticoagulants, their anticoagulant effect is enhanced.
When used simultaneously with tricyclic antidepressants, absorption of phenylbutazone may be impaired.
With simultaneous use with acetylsalicylic acid, its uricosuric effect decreases.
Butadione can enhance the effect of drugs that cause photosensitivity.
With simultaneous application with methylphenidate, the concentration of phenylbutazone in the blood plasma increases.
The cases of increasing the concentration of phenytoin in the blood plasma with the development of toxic reactions with its simultaneous application with phenylbutazone are described.
With simultaneous use with Phenobarbital there is a slight decrease in the concentration of phenylbutazone in the blood plasma.
Analogues of Butadion
Structural analogs for the active substance:
- Butadione OBL;
- Phenylbutazone.
Analogues on the curative effect (remedies for the treatment of synovitis):
- Arthrosylen;
- Aertal;
- Betalgon;
- Witsef;
- Voltaren;
- Voltaren Emulgel;
- Hepatrombin;
- Diqlovit;
- Diclofenac;
- Deep Relief;
- Diprospan;
- Dolgit;
- Dolobien;
- Ibuprofen;
- Indovazin;
- Indomethacin;
- Kenalog;
- Metindole;
- Nyz;
- Naisylate;
- Naklofen;
- Nalgezin;
- Nalgezin forte;
- Nimesil;
- Nimesulide;
- Niflugel;
- Oflotsid;
- Piroxicam;
- Polcortolone;
- Prednisolone;
- Rapent;
- Sulaydine;
- Surgham;
- Fastum gel;
- Febrofide;
- Finalgon;
- Fleksen;
- Celeston.