Noofen
In this article, you can read the instructions for using the drug Noofen. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Noophen in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Noofen in the presence of existing structural analogs. Use for the treatment of teak, stuttering, enuresis in adults, children, as well as during pregnancy and lactation. Composition of the preparation.
Noofen - a nootropic preparation, a derivative of gamma-aminobutyric acid and phenylethylamine. Possesses tranquilizing properties, stimulates memory and learning ability, increases physical ability to work, eliminates psychoemotional tension, anxiety, fear and improves sleep. Does not affect cholino- and adrenergic receptors.
The drug lengthens the latent period and shortens the duration and severity of nystagmus. Significantly reduces the manifestations of asthenia and vasovegetative symptoms, incl. headache, a feeling of heaviness in the head, sleep disturbance, irritability, emotional lability, increases mental performance, improves well-being, increases interest and initiative, motivation for active activity without sedation or stimulation.
Unlike tranquilizers under the influence of Noophen, psychological indicators (attention, memory, speed and accuracy of sensory-motor reactions) are improved. No formation of addiction and dependence on the drug, withdrawal syndrome was noted.
Composition
Aminophenylbutyric acid hydrochloride + excipients.
Pharmacokinetics
After ingestion, the drug is well absorbed and penetrates into all tissues of the body. About 0.1% of gamma-amino-beta-phenylbutyric acid hydrochloride permeates the brain tissue from the accepted dose of the drug; in patients at young and old age, an increase in penetration through the blood-brain barrier (BBB) is possible.After 3 hours of gamma-amino-beta-phenylbutyric acid, the hydrochloride is found in the urine, at the same time, the concentration in the brain tissues does not decrease, it is detected in the brain after another 6 hours. When the drug is not used again, the drug does not accumulate in the body. The greatest binding of gamma-amino-beta-phenylbutyric acid hydrochloride occurs in the liver (80%), it is not specific. 80-95% of the drug is metabolized in the liver to pharmacologically inactive metabolites. 5% is excreted from the body by the kidneys in unchanged form. The next day after taking gamma-amino-beta-phenylbutyric acid hydrochloride, the hydrochloride can be detected only in the urine; it is detected in the urine after 2 days after administration, but the detectable amount is 5% of the administered dose.
Indications
- asthenic and anxiety-neurotic states;
- stuttering, tics and enuresis in children;
- insomnia and nightly anxiety in the elderly;
- Meniere's disease, dizziness associated with dysfunction of the vestibular analyzer of various genesis;
- prevention of motion sickness with kinetosis;
- as part of complex therapy for alcohol withdrawal syndrome for the relief of psychopathological and somatovegetative disorders.
Forms of release
Capsules 250 mg.
Other dosage forms, be it pills, drops or powder, at the time of publication in the Directory did not exist.
Instructions for use and reception scheme
Inside after eating, squeezed with water. Capsule can not be chewed.
Asthenic and anxiety-neurotic states: adults - 250-500 mg 3 times a day. The maximum single dose for adults is 750 mg, for patients over 60 years - 500 mg. If necessary, the daily dose is increased to 2.5 g. The course of treatment is 4-6 weeks.
Stammering, tics and enuresis in children aged 8 to 14 years - 250 mg 2-3 times a day; in children older than 14 years - doses for adults.
Insomnia and night alarm in elderly patients - 250-500 mg 3 times a day.
To eliminate dizziness in the dysfunction of the vestibular analyzer of infectious genesis (otogenous labyrinthite) and Meniere's disease: during the exacerbation, 750 mg 3 times a day is prescribed for 5-7 days, with a decrease in the severity of vestibular disorders - 250-500 mg 3 times a day for 5-7 days, then 250 mg once a day for 5 days. With a relatively easy flow of diseases - 250 mg twice a day for 5-7 days, then 250 mg once a day for 7-10 days.
To eliminate dizziness with dysfunctions of the vestibular analyzer of vascular and traumatic genesis, 250 mg 3 times a day for 12 days are prescribed.
For the prevention of motion sickness with kinetosis: 250-500 mg once for 1 hour before the proposed journey or when the first symptoms of motion sickness appear. The anti-soothing action of Noophen is enhanced by increasing the dose of the drug. At the onset of severe manifestations of seasickness (including indomitable vomiting), taking the drug orally is ineffective, even at a dose of 750-1000 mg.
As part of complex therapy for alcohol withdrawal syndrome for the relief of psychopathological and somatovegetative disorders in the first days of treatment, 250-500 mg is prescribed 3 times a day and 750 mg at night with a gradual decrease in the daily dose to the usual for adults.
Do not take a double dose to replace the missed dose.
In patients with renal and / or liver failure with prolonged use, it is necessary to monitor the parameters of kidney and / or liver function.
If liver function is impaired, high doses of the drug may cause hepatotoxicity. In such patients, the drug is prescribed in smaller doses.
Side effect
- drowsiness and increased symptoms (at the beginning of treatment);
- dizziness;
- headache;
- nausea (at the beginning of treatment);
- allergic reactions (skin rash, itching);
- hepatotoxicity.
Contraindications
- acute renal insufficiency;
- pregnancy;
- lactation period;
- children under 8 years old (for this dosage form);
- rare congenital galactose intolerance, lactase deficiency or glucose-galactose malabsorption (because the drug contains lactose);
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
The use of Noophen during pregnancy and during breastfeeding is not recommended, because there is not enough clinical observation.
In experimental animal studies, mutagenic, teratogenic and embryotoxic effects of the drug have not been established.
Use in children
Contraindicated in childhood to 8 years.
special instructions
With prolonged use, it is necessary to control the cellular composition of the blood, the liver function indicators.
With caution should prescribe the drug to patients with erosive and ulcerative gastrointestinal diseases (because of the irritant effect of the drug is recommended to prescribe the drug in smaller doses).
Impact on the ability to drive vehicles and manage mechanisms
During the treatment period, patients need to be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions, as some patients may experience CNS disorders such as drowsiness and dizziness.
Drug Interactions
In order to mutually potentiate, Noophen can be combined with other nootropic drugs, reducing the dose of Noophen and the combined medicines.
Extends and intensifies the effect of hypnotic, neuroleptic and antiparkinsonian drugs.
Analogues of the drug Noophen
Structural analogs for the active substance:
- Anvifen;
- Phenibut.
Analogues on the curative effect (funds for the treatment of enuresis):
- Amitriptyline;
- Anvifen;
- Gopantam;
- Melipramine;
- Pantogam;
- Spazmeks;
- Fenibut;
- Enablex.