Lidevin
In this article, you can read the instructions for using the drug Lidevin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Lidevin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Lidevin analogs in the presence of existing structural analogues. Use for the treatment of chronic alcoholism in adults, children, as well as during pregnancy and lactation. Composition of the preparation.
Lidevin - A combined drug for the treatment of alcohol dependence, is a combination of Disulfiram with group B vitamins.
Disulfiram is an inhibitor of acetaldehyde dehydrogenase. Blocking of acetaldehyde dehydrogenase leads to an increase in the concentration of acetaldehyde, which is a metabolite of ethyl alcohol.Acetaldehyde causes negative feelings (including flushing, nausea, vomiting, tachycardia, low blood pressure), which make it extremely unpleasant alcohol after taking Lidevina. This leads to a conditioned reflex aversion to the taste and smell of alcoholic beverages.
The maximum therapeutic effect is achieved 12 hours after ingestion and can last for 10-14 days after discontinuation of treatment.
The combination of disulfiram with vitamin B3 (niacinamide) and B4 (adenine) provides pronounced clinical effect upon receipt of even small doses of alcohol, has minimal side effects, reduces the toxicity of disulfiram ensures prevention of alcoholic neuropathy and hypovitaminosis.
Composition
Disulfiram + Nicotinamide (vitamin B3) + Adenine (vitamin B4) + auxiliary substances.
Pharmacokinetics
After oral absorption of Lidevin from the gastrointestinal tract is 70-90%. Disulfiram is rapidly metabolized, until recovering dithiocarbamate which is output as a glucuronate conjugate or turns in diethylamine and carbon sulphide, part (4-53%) is output through the lungs.
Indications
- treatment and prevention of recurrences of chronic alcoholism.
Forms of release
Tablets 500 mg + 300 μg + 500 μg.
Other dosage forms, be it capsules or drops, at the time of publication of the drug in the directory did not exist.
Instructions for use and dosing regimen
The drug is prescribed after a thorough examination of the patient and a warning about the consequences and complications of therapy.
The dose of the drug is set at the rate of disulfiram and taken internally 125-500 mg 2 times a day, according to an individual scheme. After 7-10 days of therapy, a disulfiramalcoholic sample is taken (20-30 ml of 40% vodka after taking 500 mg of the drug), with a weak reaction, the dose of alcohol is increased by 10-20 ml (the maximum dose is 100-120 ml). The sample is repeated after 1-2 days in the hospital and 3-5 days after an outpatient treatment, if necessary - with the correction of the doses of alcohol and / or the drug. In the future, you can use a maintenance dose of 125-200 mg per day for 1-3 years.
Side effect
- metallic taste in the mouth;
- unpleasant odor in patients with colostomy (associated with carbon sulphide);
- polyneuropathy of the lower extremities;
- optic neuritis;
- memory impairment;
- confusion of consciousness;
- asthenia;
- headache;
- skin allergic reactions;
- hepatitis (in patients with nickel eczema, not suffering from chronic alcoholism);
- gastritis;
- arrhythmia;
- attacks of angina pectoris;
- myocardial infarction;
- respiratory insufficiency;
- cardiovascular collapse;
- edema of the brain;
- psychoses (reminiscent of alcoholic);
- a thrombosis of vessels of a brain.
When drinking alcohol in an amount exceeding 40-80 ml of 40% vodka, it is possible to develop severe violations of the functions of the cardiovascular and respiratory systems, edema, seizures. At the same time urgently conduct detoxification therapy, inject analeptics, if necessary, additional symptomatic therapy is indicated.
Contraindications
Absolute:
- diseases of the cardiovascular system in the stage of decompensation;
- neuritis of the auditory nerve;
- glaucoma;
- optic neuritis;
- bronchial asthma;
- emphysema of the lungs;
- pulmonary tuberculosis;
- severe hepatic impairment;
- disorders of hematopoiesis;
- diabetes;
- thyrotoxicosis;
- epilepsy and convulsive syndrome of any genesis;
- mental illness;
- stomach ulcer in the phase of exacerbation;
- kidney disease;
- malignant neoplasms;
- polyneuritis of various etiologies;
- pregnancy;
- hypersensitivity to the components of the drug.
Relative:
- cardiovascular disease in the stage of compensation;
- older age (over 60 years);
- peptic ulcer of the stomach and duodenum in the phase of remission;
- residual effects after cerebrovascular accident;
- disulfiramovye (antabusnye) psychoses in the anamnesis.
Application in pregnancy and lactation
Lidevin is contraindicated in pregnancy.
Use in children
In children, the drug is not used.
Application in elderly patients
Relatively contraindicated in the elderly (over 60 years).
special instructions
It is necessary to warn patients about the possible consequences of concurrent use of alcohol or taking medications containing ethanol.
Drug Interactions
Combinations are contraindicated
With the simultaneous reception with alcohol, the reaction of intolerance develops (hot flushes, erythema, vomiting, tachycardia). Avoid taking drinks and medicines containing ethanol.
Unwanted combinations
With simultaneous application of Lidevin and isoniazid, there may be a violation of behavior and coordination.
With simultaneous use with drugs from the group of derivatives of nitro-5-imidazole (metronidazole, ornidazole, seksnidazol, tinidazol), it is possible to develop delirious disorders, confusion.
With the simultaneous application of phenytoin, the development of toxic effects of phenytoin (due to a slowing of its metabolism and an increase in the concentration in the blood plasma) is possible.
Combinations that require caution
With the simultaneous use of Lidevin and Warfarin (or other oral anticoagulants), the risk of bleeding increases because of the increased effect of warfarin (slowing the biotransformation of the latter).
Lidevin slows down the biotransformation of theophylline, therefore, with simultaneous use, a dose reduction of theophylline is required depending on the clinical symptoms and its concentration in the blood plasma.
With the simultaneous use of Lidevin potentiates the sedative effect of benzodiazepines by inhibiting the oxidative pathway of metabolism of the latter, especially chlordiazepoxide and diazepam.The dose of benzodiazepine should be adjusted in accordance with clinical manifestations.
With the simultaneous use of Lidevin and tricyclic antidepressants, it is possible to intensify the reactions of alcohol intolerance, especially if patients take alcohol while taking Lidevin.
Analogues of Lidevin drug
Structural analogs for the active substance:
- Antabus;
- Disulfiram;
- Teturam;
- Esperal.
Analogues on the curative effect (funds for the treatment of alcoholism):
- Adress;
- Amylonosar;
- Antabus;
- Antakson;
- Baclosan;
- Biotredin;
- Vivitrol;
- Haloperidol;
- Heminearrin;
- Diazepam;
- Doxepine;
- Zorex;
- Clion;
- Colme;
- Contamnol;
- Xanax;
- Limonar;
- Lucetsam;
- Mebicar;
- Mebiks;
- Memotropized;
- Metadoxyl;
- Metovit;
- Metronidazole;
- Naltrexone;
- Napoton;
- Nootropil;
- Pikamilon;
- Piracetam;
- Selincro;
- Sibazon;
- Sonapaks;
- Teturam;
- Thiodasin;
- Uni thiol;
- Phenotropil;
- Fluanexol;
- Elenium;
- Esperal.