Sidnofarm - instructions for use, analogs, reviews and release forms (2 mg tablets) of the drug for the treatment of angina attacks and heart pain in adults, children and pregnancy. Composition and alcohol

In this article, you can read the instructions for using the drug Sidnofarm. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Sidnofarm in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Sidnofarma in the presence of existing structural analogs. Use for the treatment of angina attacks and heart pain in adults, children, as well as during pregnancy and lactation.Composition and interaction of the drug with alcohol.

Sidnofarm - a peripheral vasodilator, an antianginal drug from the sydnonimine group. Expands peripheral venous vessels, has antiaggregant, analgesic and antianginal action. Venodilating activity is caused by the release after a number of metabolic transformations of nitric oxide (NO), which stimulates soluble guanylate cyclase, in this connection molsidomine (active ingredient of Sidnofarm) is considered as donor NO. As a result, there is accumulation of cGMP, which helps to relax the smooth muscles of the vessel walls (mostly veins). Decrease in preload, even without a direct effect on myocardial contractility, leads to a restoration of the relationship between myocardial oxygen demand and its intake disturbed in IHD (oxygen demand decreases by 26%). The drug relieves spasm of the coronary arteries, improves the collateral circulation.

Increases the tolerance of the load, reduces the number of attacks of angina with physical activity. It suppresses the early phase of platelet aggregation, reduces the secretion and synthesis of serotonin, thromboxane, and other proaggregants.

In patients with chronic heart failure, reducing preload, contributes to a decrease in the size of the heart chambers. Reduces the pressure in the pulmonary artery, reduces the filling of the left ventricle and the stress of the wall of the myocardium, the shock volume of blood.

The action begins 20 minutes after ingestion, reaches a maximum of 0.5-1 h and lasts up to 6 hours. The development of tolerance with a decrease in efficacy during prolonged therapy is uncharacteristic (in contrast to nitrates).

Composition

Molsidomin + excipients.

Pharmacokinetics

After oral administration, it is almost completely absorbed from the digestive tract. Bioavailability is 60-70%. When ingested after a meal, the absorption is slowed down, but not reduced. Virtually does not bind to blood plasma proteins. Do not cumulate. In the liver, it is metabolized to form a pharmacologically active compound SIN-1, (3-morpholino-sydnonimine), from which a very unstable substance SIN-1a (N-morpholino-N-aminosinonitrile) forms NO to form a pharmacologically inactive SIN-lc compound. In the course of metabolism, other metabolites are formed. It is excreted by the kidneys by 90% (in the form of metabolites), 9% by the intestine.

Indications

• prevention of angina attacks;
• chronic heart failure (as part of a combination therapy with cardiac glycosides, diuretics).

Forms of release

Tablets 2 mg.

Instructions for use and dosage

The dosage regimen and the duration of therapy are set individually. The drug is taken orally regardless of food intake. The tablets are swallowed whole, without chewing and washing down with a sufficient amount of liquid.

The drug is prescribed in the initial dose of 1-2 mg (0.5-1 tablet) 2 times a day. If the therapeutic effect is insufficient, the frequency of the appointment is increased up to 3 times a day. The maximum daily dose is 6 mg.

Side effect

• a decrease in blood pressure;
• collapse (with initially elevated blood pressure, the severity of its decrease is greater than at baseline normal or lower blood pressure);
• redness of facial skin;
• tachycardia;
• headache (usually minor, disappears during further treatment);
• slowing the speed of psychomotor reactions (mostly at the beginning of treatment);
• dizziness;
• nausea;
• loss of appetite;
• diarrhea;
• skin rash;
• itching;
• bronchospasm;
• anaphylactic shock.

Contraindications

• acute myocardial infarction, flowing with arterial hypotension;
• severe arterial hypotension (systolic blood pressure below 100 mm Hg);
• collapse;
• cardiogenic shock;
• low filling pressure of the left ventricle;
• toxic pulmonary edema;
• simultaneous reception sildenafila;
• pregnancy;
• lactation period;
• children and adolescents under 18 years of age (efficacy and safety not established);
• hypersensitivity to the drug.

Application in pregnancy and lactation

Sidnofarm application is contraindicated in pregnancy. If it is necessary to prescribe the drug during lactation, breastfeeding should be abandoned.

Use in children

Contraindicated in children and adolescents under the age of 18 years (efficacy and safety not established).

special instructions

The drug is not used to stop an attack of angina pectoris.

With caution and under the control of blood pressure, the first dose of the drug is prescribed, tk. possible intense headaches and excessive reduction of blood pressure with loss of consciousness.

Elderly patients with impaired liver and kidney function and arterial hypotension require dose adjustment.

During treatment should avoid drinking alcohol.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment (especially at the beginning of therapy) it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities that require increased attention and speed of psychomotor reactions.

Drug Interactions

Simultaneous application of Sidnofarm with vasodilating, antihypertensive agents and ethanol (alcohol) increases the severity of the hypotensive effect.

With the simultaneous use of Sidnofarm with acetylsalicylic acid, its antiplatelet effect is enhanced.

Analogues of the drug Sidnofarm

Structural analogs for the active substance:

• Dilaside;
• Corvatone.

Analogues for the pharmacological group (nitrates and nitrate-like agents):

• Amyl nitrite;
• Aerosonite;
• Gluconite;
• Deposits 10;
• Dilaside;
• Dinisorb;
• Isacardin;
• From MacArthard;
• Is Mac Spray;
• Isoket;
• Isolong;
• Isosorbide dinitrate;
• Isosorbide mononitrate;
• Cardiac;
• Cardix;
• Carneland;
• Corvaton;
• Monizide;
• Monizol;
• Mono Mack;
• Monolong;
• Mononite;
• Monosan;
• Monochinkwe;
• Monochinkwe retard;
• Nirmine;
• Nitradisk;
• Nitro;
• NitroNick;
• Nitroglycerine;
• Nitrolong;
• Nitromint;
• Nitrogen;
• Nitroung forte;
• Nitrosorbide;
• Olicard;
• Pectrol;
• Pentacard;
• Perlingant;
• Sorbimon;
• Sustak mite;
• Sustak forte;
• Sustonite;
• Trinitrolong;
• Erinit;
• Efoks;
• Efoks long.

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