Medazepam - instructions for use, real counterparts and release form (tablets of 10 mg), a tranquilizer drug for the treatment of depression, neurosis, anxiety disorders, migraine in adults, children and in pregnancy. Composition and alcohol

In this article, you can read the instructions for using the drug Mezapam. There are reviews of visitors to the site - consumers of this medication, as well as opinions of medical experts on the use of Mezapam in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Mesapam in the presence of existing structural analogues. Use for the treatment of depression, neurosis, anxiety disorders,migraine in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Mezapam - An anxiolytic agent (tranquilizer), a benzodiazepine derivative. Has anxiolytic, miorelaksiruyuschee and antiepileptic effect, has a slightly pronounced timolepticheskim effect. Sedative and hypnotic effects are less pronounced than in typical benzodiazepine tranquilizers, so medazepam (the active substance of the drug Mezapam) is referred to the group of so-called "daytime" tranquilizers.

Interacts with the benzodiazepine receptors of the limbic system and the ascending activating formation of the brainstem, promotes the opening of the chlorine channels, which leads to increased inhibitory effect of GABA in the central nervous system.

Eliminates anxiety, fear, psychoneurotic tension, general motor excitement, excessive fussiness, restores emotional behavior and exerts a stabilizing effect on the autonomic nervous system. He restores a critical assessment of his own disease.Antiepileptic, central miorelaksiruyuschee, sedative and hypnotic effect is expressed to a lesser degree than in typical anxiolytic agents of benzodiazepine derivatives.

Composition

Medazepam + auxiliary substances.

Pharmacokinetics

After oral administration, it is rapidly absorbed. Absorption is 49-75%. Binding to plasma proteins - 99.8%. Metabolized by hydroxylation, N-demethylation, oxidation with the formation of active metabolites: desmethylmedazepam (nordiazepam), diazepam, desmethyldiazepam, oxazepam (7.1% dose).

Nordiazepam has a long T1 / 2, accumulates in the body and has a pronounced sedative effect. Metabolites associated with glucuronic acid are excreted by the kidneys (63-85%) and through the intestine (15-37%). After completing the intake for another 3-14 days, significant concentrations of metabolites in plasma are determined (have a long half-life).

Indications

• neuroses;
• psychopathy with anxiety;
• excitation;
• nervous tension;
• irritability;
• cardiopsychoneurosis;
• migraine (prevention of seizures);
• climacteric syndrome;
• chronic alcoholism (withdrawal syndrome);
• "school" neuroses;
• mental lability and excessive excitability in children.

Forms of release

Tablets 10 mg.

Instructions for use and dosage

Is taken internally. Adults at the beginning of treatment - 5 mg 2-3 times a day, then gradually increase the dose to 30 mg per day. In outpatient settings, doses of 5 mg in the morning and in the afternoon and 10 mg in the evening are recommended. If necessary, the dose can be increased to 40 mg per day. To the elderly and to adolescents - 10-20 mg per day; children 10 years and older - at a dose of 2 mg / kg per day. The duration of use depends on the indications and individual response of the patient to treatment.

Maximum daily doses: for adults with outpatient treatment - 40 mg, in hospital - 60 mg.

Side effect

• drowsiness;
• feeling of easy fatigue;
• headache (the first reaction to the method that disappears after a dose reduction);
• weakness;
• dizziness;
• stunned;
• anterograde amnesia;
• depression;
• confusion of consciousness;
• dysarthria;
• paresis of accommodation;
• no braking;
• aggressiveness;
• increased muscular fatigue;
• ataxia;
• decreased libido;
• decreased potency;
• menstrual cycle disorders;
• depression of the respiratory center (with airway obstruction or brain damage);
• alveolar hypoventilation (in patients with COPD with admission in high doses);
• tachycardia;
• a decrease in blood pressure;
• dry mouth;
• dyspepsia;
• retention of urine;
• spasm of the vocal cords;
• pain in the chest;
• withdrawal syndrome;
• drug dependence (especially with prolonged use);
• allergic reactions.

Contraindications

• myasthenia gravis;
• acute liver and kidney disease;
• night apnea;
• alcohol and drug addiction;
• 1 trimester of pregnancy;
• lactation period;
• children's age till 10 years;
• increased sensitivity to medazepam.

Application in pregnancy and lactation

Mezapam is contraindicated in the first trimester of pregnancy and during lactation (breastfeeding). Application in the 2nd and 3rd trimesters of pregnancy is possible only on strict indications.

Use in children

Contraindicated in children under 10 years.

In children older than 10 years, medazepam is used according to strict indications.

Application in elderly patients

Use with caution in elderly patients.

special instructions

With caution apply for renal and / or hepatic insufficiency, spinal and cerebellar ataxia, intraocular hypertension, organic lesions of the central nervous system, with respiratory failure, in elderly patients,at a serious general or common status, at pregnancy.

Mezapam should be used as short as possible, because with prolonged use, especially in high doses, there is a danger of forming drug dependence. Physical dependence is rare, but with excessive doses exceeding, there has been a development of tolerance and mental dependence. To prevent the development of abstinence syndrome, medazepam should be gradually phased out.

In the treatment with benzodiazepines, the presence of inhibition of learning ability, memorization processes has been established.

During the treatment period, do not drink alcohol.

In children, medazepam is used according to strict indications.

Impact on the ability to drive vehicles and manage mechanisms

During the period of application of Mezapam, it is not recommended to engage in potentially dangerous activities requiring rapid psychomotor reactions.

Drug Interactions

With simultaneous use with opioid analgesics, anesthesia, muscle relaxants, ethanol (alcohol), it is possible to increase the oppressive effect on the central nervous system.

With the simultaneous use of central anti-hypertensive drugs, beta-blockers, anticoagulants, the results of drug interactions are unpredictable.

With simultaneous use with cimetidine, an increase in the intensity and duration of action of medazepam, barbiturates and phenytoin may decrease its effectiveness.

Oral contraceptives can inhibit the metabolism of medazepam, which leads to increased intensity and duration of its action.

Reduces the effectiveness of levodopa, enhances the effect of phenytoin.

Analogues of the drug Mezapam

Structural analogs for the active substance:

• Nobrethum;
• Rudotel.

Analogues for the pharmacological group (tranquilizers):

• Adaptol;
• Alzolam;
• Alprazolam;
• Anvifen;
• Atarax;
• Afobazol;
• Bromazepam;
• Bromide;
• Valium Rosh;
• Hydroxysine;
• Grandaxin;
• Diazepam;
• Diazepec;
• Zolomax;
• Ipronal;
• Kassadan;
• Xanax;
• Xanax retard;
• Lexotan;
• Librax;
• Loram;
• Laurafen;
• Mebicar;
• Mebiks;
• Mexiprim;
• Mexicin;
• Napoton;
• Neurophasole;
• Neurol;
• Nozepam;
• Noophen;
• Oxazepam;
• Relanium;
• Relium;
• Seduxen;
• Sibazon;
• Stresam;
• Tenoten;
• Tenoten for children;
• Tofizopam;
• Fesipam;
• Phenazepam;
• Fenibut;
• Phenorelaxane;
• Front;
• Helex;
• Elenium.

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