Biltricid - instructions for use, analogs, testimonials and release forms (600 mg tablets) of the drug for the treatment of schistosomiasis, opisthorchiasis, diphyllobothriasis and other worms and parasites in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Biltricide. There are reviews of visitors to the site - consumers of this medication, as well as opinions of specialists on the use of Biltricide in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Biltricid analogues in the presence of existing structural analogues.Use for the treatment of schistosomiasis, opisthorchiasis, diphyllobothriasis and other worms and parasites in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Biltricide - antihelminthic agent, pyrazinisoquinoline derivative. Has a wide range of action, which includes many trematodes and cestodes. Thus, praziquantel (the active ingredient of Biltricide) is highly active against all pathogens of human schistosomiasis, clonorchosis, paragonimosis, opisthorchiasis, as well as against Fasciolopsis buski, Hetorophyes heterophyes and Metagonimus yokogawai (intestinal flukes). Among the trematodes to praziquantel, Fasciola hepatica is stable, the mechanism of resistance is not clear. Praziquantel is highly effective against causative agents of intestinal cestodias: hymenolepidosis (Hymenolepsis nana), diphyllobothrium latum, Taeniarhynhus saginatus, Taenia solium, also acts on cysticerci.

For prazikvantel two main effects are observed with respect to sensitive helminths. In low doses, it causes an increase in muscle activity, followed by a reduction in muscle and spastic paralysis. In slightly higher doses, it causes damage to the tegumen (the outer cover of flat worms). The mechanism of action is not finally clarified.It is believed that the effect of praziquantel is due to its ability to increase the permeability of membranes for calcium ions (and some other single- and divalent cations).

Composition

Praziquantel + auxiliary substances.

Pharmacokinetics

Quickly and completely absorbed from the digestive tract. Binding to plasma proteins - 80%. Metabolized in the liver with the formation of inactive mono- and polyhydroxylated metabolites. Mainly excreted by the kidneys (within 4 days - 80%), mainly in the form of metabolites: 90% is excreted within 24 hours. A small amount is excreted with feces. In small amounts enters the breast milk. With violations of kidney function, excretion slows down, liver damage reduces the intensity of metabolism, which is accompanied by a longer stay of unchanged praziquantel in the body with the creation of high concentrations.

Indications

• schistosomiasis, including intestinal schistosomiasis and schistosomiasis of the genitourinary system;
• opisthorchiasis;
• clonorhoz;
• paragonymosis;
• metagonism;
• Fasciolopsidosis and other trematodes caused by sensitive helminths;
• intestinal cestodiasis: hymenolepiasis, diphyllobothriasis, teniarinhoz, teniosis;
• neurocysticercosis.

Forms of release

Tablets coated with 600 mg.

Other dosage forms, whether capsules, drops or suspensions, do not exist.

Instructions for use and reception scheme

Inside, whole, not liquid, with a small amount of liquid, before or during meals. If a single dose is recommended per day, then the pill should be taken in the evening. With repeated use of the drug during the day, an interval between doses of at least 4 and not more than 6 hours is recommended.

Adults and children over 4 years. Biltricide doses are selected strictly individually and depend on the type of pathogen.

Schistosoma haematobium - 40 mg / kg body weight once. Duration of treatment - 1 day.

Schistosoma mansoni and Schistosoma intercalatum - 40 mg / kg once a day or 20 mg / kg 2 times a day. Duration of treatment - 1 day.

Schistosoma japonicum, Schistosoma mekongi - 60 mg / kg once a day or 30 mg / kg 2 times a day. Duration of treatment - 1 day.

Clonorchis sinensis, Opisthorchis viverrini - 25 mg / kg 3 times a day for 1-3 days.

Paragonimus westermani and other species - 25 mg / kg 3 times a day for 2-3 days.

Side effect

• headache;
• dizziness;
• drowsiness;
• myalgia;
• in the treatment of neurocysticercosis, the phenomena of meningism, disruption of thinking, increased intracranial pressure, hyperthermia;
• stomach ache;
• nausea;
• vomiting;
• transient elevation of the level of hepatic transaminases;
• fever;
• skin rashes.

Contraindications

• hypersensitivity to praziquantel;
• cysticercosis of the eye;
• 1 trimester of pregnancy;
• lactation;
• children under 4 years;
• liver failure;
• cysticercosis of the liver.

Application in pregnancy and lactation

Biltricide is contraindicated for use in the first trimester of pregnancy and during lactation (breastfeeding).

In the 2nd and 3rd trimesters of pregnancy prazikvantel is used only on strict indications.

If it is necessary to use during lactation, it is recommended to stop breastfeeding on the day of taking praziquantel and for the next 72 hours.

Use in children

Contraindicated in children under 4 years. Safety of the drug in children younger than 4 years is not established.

special instructions

In the case of cysticercosis, Biltricide is not used because of the risk of developing eye tissue damage during the death of cysticerci.

Impact on the ability to drive vehicles and manage mechanisms

In the process of taking praziquantel and for the next 24 hours it is necessary to refrain from driving vehicles and other potentially dangerousactivities.

Drug Interactions

Dexamethasone reduces the concentration of Biltricide in blood plasma.

Chloroquine can lead to a decrease in the concentration of praziquantel in the blood (the mechanism of this interaction is not clear).

While the use of inducers of cytochrome P450, for example with antiepileptic drugs (phenytoin, Phenobarbital and carbamazepine), Dexamethasone concentration praziquantel in blood plasma can be reduced, and in combination with inhibitors of cytochrome P450 such as cimetidine, ketoconazole, itraconazole, Erythromycin - rise .

The simultaneous use of rifampicin (a strong inducer of cytochrome P450) with praziquantel is contraindicated.

Analogues of the drug Biltricid

Structural analogues of the active substance drug Biltricide does not. The drug contains a unique active substance in its composition.

Analogues for the pharmacological group (antihelminthic drugs):

• Vermox;
• Worming;
• Gelmodol BM;
• Helmintox;
• Decaris;
• Mebendazole;
• Medamin;
• Nemosol;
• Nemocide;
• Tansy flowers;
• Piperazine;
• Piperazine adipate;
• Pirantel;
• Pirantela pamoat;
• Piervinium;
• Sanoxal;
• Telmox 100;
• Pumpkin seeds.

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