Neurorubin - instructions for use, reviews, analogs and forms of release (injections in injectable ampoules, Forte Lactab tablets) vitamins for the treatment of neuritis, neuralgia, polyneuropathy in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Neurorubin. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Neurorubin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Neurorubin in the presence of existing structural analogues.Use for the treatment of neuritis, neuralgia, polyneuropathy in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Neurorubin - a complex vitamin preparation containing water-soluble Vitamins of group B. Vitamins of group B have a wide spectrum of biological activity, despite the similarity of pharmacological effects, each of the vitamins has a specific effect on the human body. In particular:

Vitamin B1 takes an active part in carbohydrate metabolism, with its deficiency there is an increase in the amount of lactic and pyruvic acids in the body. Participates in deamination and reamination of amino acids, thus regulating protein metabolism. In fat metabolism, vitamin B1 regulates the formation of fatty acids and catalyzes the conversion of carbohydrates into fat. The active forms of this vitamin stimulate peristalsis and secretory function of the intestine. Vitamin B1 activates ion channels in the cell membranes of neurons, thus affecting the carrying out of impulses in the nervous structures.

Vitamin B6 is involved in the synthesis of enzymes, protein and fat metabolism.The active form of this vitamin is involved in a variety of enzymatic reactions in the role of coenzyme. Pyridoxine regulates the synthesis of neurotransmitters in the synapses of the central and peripheral system, participates in the formation of myelin membrane of neurons. It improves energy production, participates in lipid and protein metabolism, regulates the synthesis of hemoglobin.

Vitamin B12 plays an important role in protein metabolism, regulates the synthesis of amino acids, purines and nucleic acids. Cyanocobalamin is required for the normal course of neuronal myelination and the formation of acetylcholine. High doses of cyanocobalamin contribute to a better conduct of nerve impulses along peripheral nervous structures and stimulate the regeneration of nerve fibers. One of the main functions of vitamin B12 is its anti-anemic effect. Cyanocobalamin has a hemopoietic effect, stimulates erythropoiesis. Vitamin B12 improves hepatic hematopoiesis, normalizes the blood coagulation system, helps reduce the amount of cholesterol in the blood.

Composition

Thiamine hydrochloride (vitamin B1) + Pyridoxine hydrochloride (vitamin B6) + Cyanocobalamin (vitamin B12) + excipients.

Pharmacokinetics

The drug Neurorubin contains high therapeutic doses of the above vitamins, which in the complex contribute to the normalization of the functions of the nervous system and regulate lipid, carbohydrate and protein metabolism. In addition, this combination of B vitamins helps to reduce pain in neuralgia of various genesis. Pharmacokinetics of the drug Neurorubin is due to the pharmacokinetic properties of its constituent components:

Thiamine. After oral administration, thiamine absorption occurs predominantly in the small intestine, duodenum and jejunum. A small amount of the drug is absorbed in the liver, the drug is metabolized in the body with the formation of thiamine carboxylic acid and pyramine. After 30 minutes after oral administration, the concentration of the drug in the blood is much lower than in organs and tissues. It is excreted from the body by the kidneys and through the intestine, both in unchanged form and in the form of metabolites.

Pyridoxine hydrochloride is well absorbed in the intestine, metabolized in the body with the formation of active metabolites of pyridoxal and pyridoxamine.In addition, the active form of the drug is pyridoxal-5-phosphate, which performs in the body the role of coenzyme. Pyridoxine is characterized by a high degree of connection with plasma proteins (up to 80%). Cumulation of the drug in the liver, muscles and CNS is noted. It is excreted from the body by the kidneys in the form of active and inactive metabolites.

For the normal absorption of cyanocobalamin in their gastrointestinal tract, the presence of the Castle factor is necessary, which ensures a normal absorption of the drug into the systemic circulation. Metabolism of cyanocobalamin, which results in the formation of an active metabolite adenosylcobalamin, occurs in the tissues. It is excreted in urine and bile. Cumulates in the liver. The half-life of the drug from the blood plasma is 5 days, of the liver tissue - about 1 year.

Indications

• diseases associated with chronic alcohol use (peripheral neuropathy, Wernicke-Korsakov syndrome);
• diabetic polyneuropathies;
• beriberi (dry and wet).

As an auxiliary therapy:

• acute and chronic neuritis and polyneuritis;
• neuralgia of the trigeminal nerve, cervicobrachial neuralgia, ischialgia.

Forms of release

Solution for injections (injections in ampoules).

Coated tablets (Neurorubine Forte Lactab).

Instructions for use and dosing regimen

Ampoules

In severe cases, at the beginning of the treatment, 3 ml (1 ampoule) is administered intramuscularly every day or every other day until the pain decreases. Then switch to the introduction of 3 ml (1 ampoule) 1 or 2 times a week.

In moderate cases appoint 3 ml 1-2 times a week.

The duration of therapy is determined individually, depending on the nature and course of the disease.

To open the ampoule, keep it labeled (as a dot) up, then you need to shake it completely, so that all the liquid is in the bottom of the ampoule. The head of the ampoule is broken off over the markings.

Pills

Coated tablets, Neurorubin Forte Lactab are taken orally with a sufficient amount of water, preferably before meals or at meals, it is not recommended to divide or chew tablets coated with a film coat. Adults usually appoint 1-2 tablets a day. The duration of the course of treatment is usually 1 month.

Side effect

• angioedema (mainly in patients with hypersensitivity);
• allergic reactions (multi- and polymorphic erythema);
• anaphylactoid reactions in predisposed patients;
• the prolactin excretion is inhibited;
• feeling restless;
• cases of involuntary movements;
• the emergence of peripheral sensory neuropathy;
• tachycardia;
• collapse (mainly in patients with increased sensitivity);
• cyanosis;
• pulmonary edema (predominantly in patients with hypersensitivity);
• nausea;
• bleeding from the gastrointestinal tract (in patients with hypersensitivity);
• itching;
• urticaria (mainly in patients with hypersensitivity);
• acne;
• deterioration of the course of common acne or acne;
• sudden sweating;
• sensation of weakness;
• dizziness.

Contraindications

• hypersensitivity to the components of the drug;
• psoriasis (due to possible worsening of the symptoms of the disease);
• pregnancy;
• breast-feeding;
• childhood.

Application in pregnancy and lactation

Neurorubin is contraindicated in pregnancy and lactation (breastfeeding).

Clinical studies of the use of Neurorubin during pregnancy have not been conducted.Vitamin B6 penetrates into breast milk and passes through the placental barrier.

Use in children

Contraindicated in childhood.

There is no experience of using the drug in children, so the drug is not prescribed for children.

special instructions

Intramuscular injections of vitamin B12 can cause anaphylactoid reactions in patients with hypersensitivity.

Impact on the ability to drive vehicles and manage mechanisms

Studies of the effect of the drug Neurorubin on the reaction rate when driving vehicles or working with mechanisms have not been conducted. Therefore, it will be more correct to assume that the drug has a negative effect on the ability to drive vehicles and equipment.

Drug Interactions

High doses of vitamin B6 (corresponding to the content of this vitamin in the drug Neurorubin) can reduce the therapeutic effect of levodopa in Parkinson's disease.

When combined, may increase the toxicity of isoniazid.

Theosemycarbazone and 5-fluorouracil are antagonists of vitamin B1.

Antacids slow the absorption of vitamin B1.

Pharmaceutical interaction

Neurorubin should not be mixed with other drugs because of the lack of studies on the compatibility of solutions.

Analogues of the drug Neurorubin

Structural analogs for the active substance:

• Binavit;
• Vitagamma;
• Vitaxon;
• Complym B;
• Milgamma;
• Neurovitan;
• Trigamma.

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