Flemoxin Solutab - instructions for use, analogs, testimonials and release forms (tablets 125 mg, 250 mg, 500 mg and 1000 mg) of the drug for the treatment of angina, sinusitis and other infections in adults, children and pregnancy
In this article, you can read the instructions for using the drug Flemoxin Solutab. Comments of visitors of the site - consumers of this medication, as well as opinions of specialists on the use of Flemoxin Solutab in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Flemoxin Solutab in the presence of existing structural analogues. The use for the treatment of angina, sinusitis and other infections in adults, children,as well as during pregnancy and lactation.
Flemoxin Solutab - an antibiotic of a group of semisynthetic penicillins of a wide spectrum of action. It is a 4-hydroxyl analogue of ampicillin. Has a bactericidal effect. It is active against aerobic gram-positive and gram-negative bacteria.
To Amoxicillin (the active substance of the preparation Flemoxin Solutab) microorganisms producing penicillinase are resistant.
In combination with metronidazole, it shows activity against Helicobacter pylori. It is believed that amoxicillin inhibits the development of Helicobacter pylori resistance to metronidazole.
Between amoxicillin and ampicillin there is cross-resistance.
The spectrum of antibacterial action expands with simultaneous use of amoxicillin and clavulanic acid beta-lactamase inhibitor. In this combination, the activity of Flemoxin Solutab increases with respect to Bacteroides spp., Legionella spp., Nocardia spp., Pseudomonas (Burkholderia) pseudomallei. However, Pseudomonas aeruginosa, Serratia marcescens and many other Gram-negative bacteria remain resistant.
Pharmacokinetics
When ingestion Flemoxin Solutab quickly and completely absorbed from the digestive tract, does not break down in the acidic environment of the stomach. When the dose is doubled, the concentration also doubles.In the presence of food in the stomach does not reduce the total absorption. Widely distributed in tissues and body fluids. High concentrations of amoxicillin in the liver are reported (therefore simultaneous intake of ethanol (alcohol) adversely affects this organ with the possibility of developing liver failure).
About 60% of the dose taken orally is excreted unchanged in the urine by glomerular filtration and tubular secretion. Some amount of amoxicillin is determined in the feces.
In small amounts, amoxicillin penetrates through the BBB during inflammation of the soft dura mater.
Indications
- Infectious and inflammatory diseases (respiratory, genitourinary, skin) caused by sensitive microorganisms, including bronchitis, pneumonia, tonsillitis, pyelonephritis, urethritis, gastrointestinal infections, gynecological infections, infectious diseases of the skin and soft tissues, listeriosis, leptospirosis, gonorrhea;
- For use in combination with metronidazole: chronic gastritis in the phase of exacerbation, peptic ulcer of the stomach and duodenum in the acute phase associated with Helicobacter pylori.
Forms of release
Tablets are dispersible 125 mg, 250 mg, 500 mg and 1000 mg.
Instructions for use and dosage
The drug is taken orally. The drug is prescribed before, during or after a meal. The tablet can be swallowed whole, divided into parts or chewed with a glass of water, and can also be diluted in water to form a syrup (in 20 ml) or a suspension (in 100 ml) with a pleasant fruit taste.
The dosage regimen is set individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.
In the case of infectious-inflammatory diseases of mild and moderate severity, the use of the drug according to the following scheme is recommended: adults and children over 10 years of age are prescribed 500-750 mg 2 times a day or 375-500 mg 3 times a day; children aged 3 to 10 years are prescribed 375 mg twice a day or 250 mg 3 times a day; children aged 1 to 3 years are prescribed 250 mg twice a day or 125 mg 3 times a day.
The daily dose of the drug for children (including children under 1 year) is 30-60 mg / kg per day, divided into 2-3 doses.
In the treatment of severe infections, as well as with hard-to-reach foci of infection (eg, acute otitis media), a three-time administration is recommended.
In chronic diseases, recurrent infections, heavy infections, adults are prescribed 0.75-1 g 3 times a day; Children - 60 mg / kg per day, divided into 3 doses.
In acute uncomplicated gonorrhea appoint 3 g of the drug in 1 dose in combination with 1 g of probenecid.
Patients with impaired renal function with KK≤10 ml / min dose of the drug reduced by 15-50%.
In the case of infections of mild and moderate severity, the drug is taken within 5-7 days. However, for infections caused by Streptococcus pyogenes, the duration of treatment should be at least 10 days.
Taking the drug should be continued within 48 hours after the disappearance of the symptoms of the disease.
Side effect
- change in taste;
- nausea, vomiting;
- diarrhea;
- dysbiosis;
- stomatitis, glossitis;
- hepatic cholestasis;
- pseudomembranous and hemorrhagic colitis;
- leukopenia, neutropenia, thrombocytopenic purpura, eosinophilia, thrombocytopenia, agranulocytosis, hemolytic anemia;
- excitement, anxiety;
- insomnia;
- ataxia;
- confusion of consciousness;
- behavior change;
- depression;
- peripheral neuropathy;
- headache;
- dizziness;
- skin reactions, mainly in the form of a specific maculopapular rash;
- hives;
- hyperemia of the skin;
- erythematous rashes;
- rhinitis;
- conjunctivitis;
- arthralgia;
- toxic epidermal necrolysis;
- allergic vasculitis;
- anaphylactic shock;
- angioedema;
- labored breathing;
- Candidomycosis of the vagina;
- superinfection (especially in patients with chronic diseases or reduced resistance of the body).
Contraindications
- hypersensitivity to the components of the drug;
- increased sensitivity to other beta-lactam antibiotics, incl. to other penicillins, cephalosporins, carbapenems.
Application in pregnancy and lactation
Use of the drug Flemoksin Soljutab during pregnancy and lactation is possible if the expected benefit of therapy for the mother outweighs the risk of side effects in the fetus and infant.
In small amounts, amoxicillin is excreted in breast milk, which can lead to the development of sensitization in the infant.
Use in children
It is used in children according to indications according to the dosing regimen (including infants and newborns).
special instructions
Prescribe the drug to patients with infectious mononucleosis and lymphocytic leukemia should be used with caution, since the likelihood of occurrence of exanthema of non-allergic genesis is high.
The presence of erythrodermia in an anamnesis is not a contraindication for the appointment of Flemoxin Solutab.
Possible cross-resistance with penicillin series and cephalosporins.
The appearance of severe diarrhea, characteristic of pseudomembranous colitis, is an indication for the withdrawal of the drug.
At course treatment it is necessary to monitor the status of the function of the organs of hematopoiesis, liver and kidneys.
It is possible to develop superinfection by increasing the microflora insensitive to the drug, which requires an appropriate change in antibacterial therapy.
Whenever estrogen-containing oral contraceptives and amoxicillin are used concurrently, other or additional contraceptive methods should be used.
Impact on the ability to drive vehicles and manage mechanisms
There was no reported adverse effect of the drug on the ability to drive vehicles or work with mechanisms.
Drug Interactions
Probenecid, phenylbutazone, oxyphenbutazone, diuretics, allopurinol, NSAIDs, to a lesser extent - Acetylsalicylic acid and sulfinpyrazone inhibit the tubular secretion of penicillins, which leads to an increase in T1 / 2 and an increase in the concentration of amoxicillin in the blood plasma.
Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) with simultaneous reception show synergism.
Possible antagonism when taken with certain bacteriostatic drugs (for example, chloramphenicol, sulfonamides).
Simultaneous administration of Flemoxin Solutab with estrogen-containing oral contraceptives can reduce the effectiveness of the latter and increase the risk of acyclic bleeding.
Antacids, glucosamine, laxatives, aminoglycosides, food, reduce absorption. Ascorbic acid increases absorption.
Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); increases absorption of digoxin.
Simultaneous use of amoxicillin with Allopurinol increases the risk of skin rash.
Analogues of the drug Flemoxin Solutab
Structural analogs for the active substance:
- Amoxisar;
- Amoxicillin;
- Amoxicillin DS;
- Amoxicillin sodium is sterile;
- Amoxicillin Sandoz;
- Amoxicillin-ratiopharm;
- Amoxicillin trihydrate;
- Amosin;
- Gonoform;
- Grunamox;
- Danemox;
- Ospamox;
- Hiconcile;
- EcoBall.
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