Prediizin - instructions for use, analogs, testimonials and release forms (tablets 35 mg prolonged action) of the drug for the treatment of IHD and prevention of angina attacks, tinnitus in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Predisin. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Predizin in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Predizin in the presence of existing structural analogues.Use for the treatment of IHD and prevention of angina attacks in cardiology, tinnitus in adults, children, as well as in pregnancy and lactation. Composition of the preparation.
Predisin - a drug that improves the metabolism of the myocardium and neurosensory organs under conditions of ischemia. Trimetazidine (active ingredient of Presidin) has an antihypoxic effect. Directly affecting the cardiomyocytes and neurons of the brain, it optimizes their metabolism and function. The cytoprotective effect is due to an increase in the energy potential, activation of oxidative decarboxylation, and rationalization of oxygen consumption (enhancement of aerobic glycolysis and fat oxidation blockade).
Supports contractility of the myocardium, prevents the decrease in intracellular content of ATP and phosphocreatine. In conditions of acidosis normalizes the functioning of membrane ion channels, prevents the accumulation of calcium and sodium ions in cardiomyocytes, normalizes the intracellular content of potassium ions. Reduces intracellular acidosis and increased phosphate content, due to myocardial ischemia and reperfusion.Prevents the damaging effect of free radicals, preserves the integrity of cell membranes, prevents the activation of neutrophils in the ischemic zone, prolongs the duration of the electrical potential, reduces the output of CKK from cells and the severity of ischemic myocardial damage.
When angina pectoris reduces the frequency of attacks and the need for nitroglycerin, after 2 weeks of treatment, exercise tolerance increases, improves the contractile function of the left ventricle in patients with ischemic dysfunction, decreases BP.
Reduces dizziness and tinnitus. In vascular pathology, the eye improves the functional activity of the retina.
Composition
Trimetazidine dihydrochloride + excipients.
Pharmacokinetics
After oral administration, Predizin quickly and almost completely absorbed into the digestive tract, bioavailability - 90%. Eating does not affect the pharmacokinetic properties of trimetazidine. Easily penetrates through the histohematological barriers. Trimetazidine is excreted from the body mainly by the kidneys (about 60% - unchanged).
Indications
- IHD: prevention of angina attacks (in complex therapy);
- cochlear-vestibular disorders of ischemic nature (dizziness, tinnitus, hearing impairment).
Forms of release
The tablets of the prolonged action, covered with a cover of 35 mg.
Instructions for use and dosing regimen
Assign inside, 35 mg (1 tablet) 2 times a day, morning and evening with meals. The duration of the course is according to the doctor's recommendation.
Side effect
- abdominal pain;
- diarrhea;
- dyspepsia;
- nausea, vomiting;
- dizziness;
- headache;
- extrapyramidal disorders (tremor, rigidity, akinesia), reversible after drug withdrawal;
- skin rash;
- itching;
- hives;
- orthostatic hypotension;
- flushes of blood to the skin of the face;
- asthenia.
Contraindications
- renal failure (CC less than 15 ml / min);
- severe liver dysfunction;
- age under 18 years (effectiveness and safety not established);
- pregnancy;
- lactation period;
- hypersensitivity to any component of the drug.
Application in pregnancy and lactation
Data on the safety of the drug during pregnancy are absent, so you should stop using Predizin during pregnancy.
Data on excretion of trimetazidine with breast milk are absent. If you need to use the drug during lactation, breastfeeding should be discontinued.
Use in children
Contraindicated in children and adolescents under the age of 18 years (efficacy and safety not established).
special instructions
Do not use the drug Predijin for stopping angina attacks! The drug is not indicated for the initial course of therapy for unstable angina or myocardial infarction. In the case of an attack of angina pectoris, the therapy should be reviewed and adapted.
Impact on the ability to drive vehicles and manage mechanisms
The use of Predizin does not affect the ability to drive vehicles and perform work that requires rapidity of psychomotor reactions.
Drug Interactions
Not indicated.
Analogues of the drug Prej.
Structural analogs for the active substance:
- Angiosyl retard;
- Antisthenes;
- Antistene CF;
- Depenorm MB;
- Medarum;
- Metagard;
- Preductal;
- Preductal MB;
- Precardard;
- Romekor;
- Rimecor MB;
- Tridoukard;
- Trimectal;
- Trimectal MB;
- Trimet;
- Trimetazide;
- Trimetazidine;
- Trimetazidine MB;
- Trimetazidine dihydrochloride;
- Trimitard MV.
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