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Neurox - instructions for use, reviews, analogs and forms of release (injections in ampoules for intravenous and intramuscular injections) drugs for the treatment of the consequences of stroke, encephalopathy, memory disorders in adults, children and pregnancy

Neurox - instructions for use, reviews, analogs and forms of release (injections in ampoules for intravenous and intramuscular injections) drugs for the treatment of the consequences of stroke, encephalopathy, memory disorders in adults, children and pregnancy

In this article, you can read the instructions for using the drug Neurox. There are reviews of visitors to the site - consumers of this medication, as well as the opinions of doctors of specialists on the use of Neurox in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Neurox with available structural analogues.Use to treat the effects of stroke, encephalopathy, memory disorders in adults, children, as well as in pregnancy and lactation. Composition of the preparation.

 

Neurox antioxidant drug. Ethyl methylhydroxypyridine succinate (EMGPS, the active substance of Neurox) is an inhibitor of free radical processes, a membrane protector possessing antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects. It belongs to the class of 3-hydroxypyridines. The mechanism of action is due to antioxidant and membrane-protective properties. Suppresses lipid peroxidation, increases the activity of superoxide oxidase, increases the ratio of lipid-protein, improves the structure and function of the cell membrane. Modulates the activity of membrane-bound enzymes, receptor complexes, which facilitates their binding to ligands, preservation of the structural and functional organization of biomembranes, transport of neurotransmitters and improvement of synaptic transmission. Increases the concentration of dopamine in the brain. Enhances compensatory activation of aerobic glycolysis and reduces the degree of inhibition of oxidative processes in the Krebs cycle under conditionshypoxia with an increase in adenosine triphosphoric acid and creatine phosphate, activates the energy-producing function of mitochondria.

 

Increases the resistance of the body to the effects of various damaging factors in pathological conditions (shock, hypoxia and ischemia, cerebral circulation disorders, intoxication with ethanol and antipsychotic drugs). It improves the metabolism and blood supply of the brain, microcirculation and rheological properties of blood, reduces platelet aggregation. Stabilizes the membranes of blood cells (erythrocytes and platelets), reducing the likelihood of hemolysis. Has hypolipidemic action, reduces the content of total cholesterol and LDL. Normalizes metabolic processes in the ischemic myocardium, reduces the necrosis zone, restores and / or improves electrical activity and myocardial contractility, and also increases coronary blood flow in the ischemic zone, increases the antianginal activity of nitro drugs, reduces the effects of reperfusion syndrome in acute coronary insufficiency.

 

Stress-protective action is manifested in the normalization of post-stress behavior, somatovegetative disorders,restoration of "sleep-wakefulness" cycles, disrupted learning and memory processes, reduction of dystrophic changes in various structures of the brain.

 

EMGPS has a pronounced antitoxic effect in the withdrawal syndrome, eliminates neurologic and neurotoxic manifestations of acute alcohol intoxication, corrects behavioral and cognitive impairment. Under the influence of ethylmethylhydroxypyridine succinate, the effect of tranquilizing, neuroleptic, antidepressant, hypnotics and anticonvulsants is enhanced, which allows to reduce their doses and reduce side effects.

 

Composition

 

Ethyl methylhydroxypyridine succinate + auxiliary substances.

 

Pharmacokinetics

 

With intramuscular injection, Neurox is determined in the blood plasma for 4 hours after administration. EMGPS quickly passes from the bloodstream into the organs and tissues and is rapidly excreted from the body. Metabolized in the liver by glucuronation. It is quickly excreted in the urine mainly in the form of metabolites (50% in 12 hours) and in a small amount - unchanged (0.3% per 12 hours). The most intense withdrawal within the first 4 hours after taking the drug.The indices of excretion in the urine of unchanged drug and metabolites have a significant individual variability.

 

Indications

  • acute disorders of cerebral circulation (as part of complex therapy - stroke or cerebral infarction);
  • encephalopathy;
  • cardiopsychoneurosis;
  • light cognitive disorders of atherosclerotic origin;
  • anxiety states in neurotic and neurosis-like states;
  • abstinence syndrome with alcoholism with a predominance of neurosis-like and vegetative-vascular disorders;
  • acute intoxication with antipsychotic drugs.

 

Forms of release

 

Solution for intravenous and intramuscular injection (injections in ampoules for injection).

 

Other dosage forms, be it pills, capsules or drops, do not exist.

 

Instructions for use and dosing regimen

 

The drug is administered intramuscularly or intravenously (either by jet or by drop, in the form of a dropper). With the infusion method of administration, the drug should be diluted in 0.9% sodium chloride solution.

 

Doses are selected individually. The initial dose is 50-100 mg 1-3 times a day, which is gradually increased until a therapeutic effect is obtained.

 

In / in the jet Neuroks injected slowly for 5-7 minutes, drip - at a speed of 40-60 drops / min.

 

The maximum daily dose is 800 mg.

 

In acute disorders of cerebral circulation Neuroks are used as part of complex therapy in the first 2-4 days IV drip 200-300 mg once a day, then in / m at 100 mg 3 times a day. The duration of treatment is 10-14 days.

 

With discirculatory encephalopathy in the phase of decompensation - in / in jet or drip in a dose of 100 mg 2-3 times a day for 14 days, then - in / m at 100 mg per day for the next 14 days.

 

For the course of prophylaxis of discirculatory encephalopathy - in / m in a dose of 100 mg 2 times a day for 10-14 days.

 

With neurocirculatory dystonia, neurotic and neurosis-like conditions - in / m 50-400 mg per day for 14 days.

 

With abstinence alcohol syndrome - in / m in a dose of 100-200 mg 2-3 times a day or intravenously drip 1-2 times a day for 5-7 days.

 

In acute intoxication with antipsychotic drugs - IV in a dose of 50-300 mg per day for 7-14 days.

 

With mild cognitive impairment in elderly patients and with anxiety disorders - in / m in a dose of 100-300 mg per day for 14-30 days.

 

Side effect

  • dryness and metallic taste in the mouth;
  • sensation of "spilling heat" throughout the body;
  • Sore throat and chest discomfort;
  • a feeling of lack of air (usually associated with an excessively high rate of administration and short-term);
  • nausea;
  • flatulence;
  • sleep disturbances (drowsiness or falling asleep);
  • allergic reactions.

 

Contraindications

  • acute renal insufficiency;
  • acute liver failure;
  • pregnancy;
  • lactation period (breastfeeding);
  • childhood;
  • hypersensitivity to the components of the drug.

 

Application in pregnancy and lactation

 

The drug Neuroks is contraindicated in pregnancy and during breastfeeding.

 

Use in children

 

Contraindicated in childhood.

 

Application in elderly patients

 

The application is possible according to the dosing regimen.

 

special instructions

 

With caution should prescribe the drug for allergic diseases and reactions in the anamnesis.

 

Impact on the ability to drive vehicles and manage mechanisms

 

During the treatment period, patients should be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

 

Drug Interactions

 

Strengthens the action of benzodiazepine anxiolytics, antiepileptic (carbamazepine), antiparkinsonian (levodopa) drugs, nitrates.

 

Reduces the toxic effects of ethanol (alcohol).

 

Analogues of the drug Neurox

 

Structural analogs for the active substance:

  • 2-ethyl-6-methyl-3-hydroxypyridine succinate;
  • 3-hydroxy-6-methyl-2-ethylpyridine succinate;
  • Medomexi;
  • Mexidant;
  • Mexidol;
  • Mexidol injection 5%;
  • Mexicor;
  • Mexipridol;
  • Mexiprim;
  • Mexicin;
  • Metostabil;
  • Cerekard;
  • Ethyl methylhydroxypyridine succinate.

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Reviews (2):
Guests
Valentina 1963
Has appointed or nominated the neurologist from noise in a head of 10 nyxes / m,but the rumor intensified and the pressure increased, which is difficult to bring down by usual drugs, the head splits. I did not fit.
Guests
alexander 1969
At me an osteochondrosis. The neurologist prescribed neurox and actovegin, after these preparations the chest hurts and the head.

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