Fokusin - instructions for use, analogs, reviews and release forms (capsules or tablets 400 μg with a modified release) of a drug for the treatment of benign prostatic hyperplasia (BPH) in men. Composition

In this article, you can read the instructions for using the drug Fokusin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Fokusina in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Fokusin in the presence of existing structural analogs. Use for the treatment of benign prostatic hyperplasia (BPH) in men. Composition of the preparation.

Fokusin - blocker of alpha1-adrenergic receptors.Selectively and competitively blocks postsynaptic alpha 1-adrenergic receptors in the smooth muscles of the prostate, bladder neck and prostatic part of the urethra and H-adrenoreceptors of the bladder, which leads to a decrease in the tone of the smooth muscles of the prostate, bladder neck and prostatic part of the urethra, improve detrusor function, decrease symptoms of obstruction and irritation associated with benign prostatic hyperplasia.

Typically, the therapeutic effect develops 2 weeks after the start of the drug, although in a number of patients, the decrease in the severity of symptoms is noted after taking the first dose.

The ability of Tamsulosin to affect alpha-adrenergic receptors is 20 times greater than its ability to interact with H-adrenergic receptors, which are located in the smooth muscle of the vessels. Due to this high selectivity, the drug does not cause any clinically significant reduction in systemic BP in both patients with arterial hypertension and in patients with normal initial BP.

Composition

Tamsulosin hydrochloride + excipients.

Pharmacokinetics

After ingestion, Fokusin is rapidly and almost completely absorbed from the digestive tract. Bioavailability of the drug is about 100%. Binding to plasma proteins - 99%. Tamsulosin is not exposed to the effect of "first passage" and is slowly biotransformed in the liver with the formation of pharmacologically active metabolites that retain high selectivity to alpha-adrenergic receptors. Most of the active substance is present in the blood in unchanged form. Tamsulosin is excreted by the kidneys, 9% of the dose is excreted unchanged.

Indications

• treatment of functional disorders in benign prostatic hyperplasia (BPH).

Forms of release

Capsules with a modified release of 400 mcg to 30, 90 and 100 pieces per package (sometimes mistakenly referred to as pills).

Instructions for use and dosing regimen

The drug is taken orally at a dose of 400 mcg (1 capsule) per day.

Capsules should be taken after the first meal, without chewing, squeezed with enough water.

Focussin can be used both as a monotherapy and in combination with inhibitors of 5α-reductase (finasteride, dutasteride).

Side effect

• dizziness;
• headache;
• sleep disturbance (drowsiness or insomnia);
• blurred vision;
• impaired vision;
• a feeling of palpitations;
• orthostatic hypotension;
• tachycardia;
• rhinitis or rhinitis;
• nose bleed;
• nausea, vomiting;
• constipation or diarrhea;
• dry mouth;
• Stevens-Johnson syndrome;
• erythema multiforme;
• exfoliative dermatitis;
• priapism;
• violations of ejaculation (including retrograde ejaculation);
• decreased libido;
• skin rash;
• itching;
• hives;
• angioedema;
• asthenic syndrome;
• backache;
• pain in the chest.

Contraindications

• orthostatic hypotension (including in the anamnesis);
• severe hepatic impairment;
• age under 18 years (effectiveness and safety not established);
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Focussin is not intended for use in women.

Use in children

Contraindicated in children and adolescents under 18 years of age (efficacy and safety not established).

special instructions

Before starting therapy with Focussin, other diseases that can cause the same symptoms as benign prostatic hyperplasia should be excluded.Before the start of treatment and regularly during therapy, a prostate examination (digital rectal examination, PSA determination) should be performed.

As with the use of other alpha1-adrenoblockers, when treated with Focussin, in some cases there may be a decrease in blood pressure, which can lead to a fainting condition. The drug Fokusin should be used with caution in patients with a predisposition to orthostatic hypotension.

At the first signs of orthostatic hypotension (dizziness, weakness), the patient should be seated or stowed.

With the development of angioedema, as well as other immunological reactions, such as Stevens-Johnson syndrome, the drug should be discontinued immediately. The patient should be under the supervision of a doctor before the elimination of this pathological condition; re-administration of tamsulosin is not allowed.

For the treatment of prostatitis and other inflammatory diseases of the prostate, the focussin is not used.

When performing surgical operations for cataracts in some patients who received tamsulosin hydrochloride at the time of surgery and in the past,there was a development of the syndrome of intraoperative instability of the iris of the eye (narrow pupil syndrome). The emergence of the syndrome of intraoperative instability of the iris can lead to an increased risk of complications from the visual organ during and after the operation.

Tamsulosin hydrochloride should not be used in combination with potent inhibitors of the CYP3A4 isoenzyme in patients with the phenotype of "slow metabolism" of the CYP2D6 isoenzyme.

Impact on the ability to drive vehicles and manage mechanisms

Care should be taken when driving vehicles and occupations requiring increased concentration of attention and speed of psychomotor reactions. In case of occurrence of a giddiness it is necessary to refrain from management of motor transport and performance of other potentially dangerous kinds of activity.

Drug Interactions

Simultaneous application of Fokusina with other alpha 1-adrenoblockers can lead to a decrease in blood pressure.

Diclofenac and indirect anticoagulants (warfarin) slightly increase the rate of excretion of tamsulosin.

Cimetidine increases the concentration of tamsulosin in plasma, and Furosemide - reduces (no significant clinical significance).

With simultaneous use of tamsulosin with atenolol, Enalapril or theophylline, there were no signs of drug interaction.

Under the conditions of diazepam, propranolol, trichloromethiazide, chloromadinone, amitriptyline, diclofenac, glibenclamide, Simvastatin and Warfarin did not change the free tamsulosin fraction in the blood plasma. Tamsulosin also had no effect on free fractions of diazepam, propranolol, trichloromethiazide and chloromadinone.

Simultaneous application of Fokusin and powerful inhibitors of CYP3A4 can cause an increase in the systemic exposure of tamsulosin. Simultaneous use of tamsulosin with Ketoconazole (a potent inhibitor of the isoenzyme CYP3A4) led to an increase in the indices of AUC and Cmax of tamsulosin by 2.8 times and 2.2 times, respectively.

Tamsulosin should not be used in combination with potent inhibitors of the CYP3A4 isoenzyme in patients with the phenotype of "slow metabolism" of the CYP2D6 isoenzyme.

Caution should be exercised when using tamsulosin simultaneously with potent and moderately active inhibitors of isoenzymeCYP3A4.

Analogues of the drug Fokusin

Structural analogs for the active substance:

• Hyperprost;
• Glansin;
• Omnik Okas;
• Omnik;
• Omsulosin;
• Proflosin;
• Revocarin;
• Sonizine;
• Tamzelin;
• Tamsulosin retard;
• Tamsulosin hydrochloride;
• Tamsulon FS;
• Tanis ERAS;
• Tanise K;
• Tulosin.

Analogues on the curative effect (remedies for the treatment of benign prostatic hyperplasia):

• Adenostop;
• Artesine;
• Afala;
• Vitaprost;
• Doxazosin;
• Grain;
• Zooxon;
• Camyrin;
• Cardura Neo;
• Kornam;
• Omnik;
• Palprostes;
• Penester;
• Permikson;
• Prazosin;
• Proscar;
• They will prostate;
• Prostakor;
• Prostamine;
• Prostamol Uno;
• Prostaplant;
• Prostatilen;
• Prosteride;
• Proflosin;
• Samprost;
• Serpens;
• Setegis;
• Sonizine;
• Spem;
• Tadenan;
• Tadimax;
• Tamzelin;
• Tamsulosin;
• Terazosin;
• Toviaz;
• Tonicardin;
• Trianol;
• Tyqveol;
• Urocardia;
• Uroprost;
• Urofin;
• Finasteride;
• Finpros;
• Haytrin;
• Cernilton.

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