Cycloferon - instructions for use, analogs, reviews and release forms (tablets 0.15 g, injections in injectable ampoules, liniment or ointment 5%) drugs for the treatment of influenza, herpes and other infections in adults, children and pregnancy

In this article, you can read the instructions for using the drug Cycloferon. Comments of visitors of the site - consumers of this medication, as well as opinions of specialists on the use of Cycloferon in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Cycloferon in the presence of existing structural analogues. Use to treat influenza, herpes, hepatitis and other infectious diseases in adults, children,as well as during pregnancy and lactation.

Cycloferon - immunomodulator. Meglumina akridonatsetat (active ingredient of the drug Cycloferon) is a low-molecular inducer of interferon, which determines a wide range of its biological activity (antiviral, immunomodulating, anti-inflammatory). Interferonogennaya activity of the drug with oral administration is maintained for 3

The main interferon-producing cells after administration of the drug are macrophages, T- and B-lymphocytes. The drug induces high titers of Interferon in organs and tissues containing lymphoid elements (spleen, liver, lungs), activates stem cells of the bone marrow, stimulating the formation of granulocytes. Cycloferon activates T-lymphocytes and natural killer cells, normalizes the balance between subpopulations of T-helpers and T-suppressors. Increases the activity of alpha interferons.

Has a direct antiviral effect, suppressing the reproduction of the virus in the early stages (1-5 days) of the infectious process, reducing the infectivity of the virus progeny, leading to the formation of defective viral particles. Increases nonspecific resistance of the organism in relation to viral and bacterial infections.

Cycloferon is effective against viruses of tick-borne encephalitis, influenza, hepatitis, herpes, cytomegalovirus, human immunodeficiency virus, papilloma virus and other viruses. In acute viral hepatitis Cycloferon prevents the transition of diseases in a chronic form. At the stage of primary manifestations of HIV infection, stabilization of immunity parameters helps.

The high effectiveness of the drug in the complex therapy of acute and chronic bacterial infections (neuroinfections, chlamydia, bronchitis, pneumonia, postoperative complications, urogenital infections, peptic ulcer) is established as a component of immunotherapy. Meglumine acridon acetate is highly effective in rheumatic and systemic connective tissue diseases, suppressing autoimmune reactions and providing an anti-inflammatory and analgesic effect.

Indications

For oral administration

As part of complex therapy in adults:

• herpetic infection;
• influenza and acute respiratory infections;
• chronic viral hepatitis B and C;
• acute intestinal infections;
• Neuroinfections, including serous meningitis, tick borelliosis (Lyme disease);
• HIV infection (stages 2A-2B);
• secondary immunodeficiencies associated with chronic bacterial and fungal infections.

As part of complex therapy in children older than 4 years:

• herpetic infection;
• prevention and treatment of influenza and acute respiratory infections;
• chronic viral hepatitis B and C;
• acute intestinal infections;
• HIV infection (stage 2A-2B).

For parenteral use

As part of complex therapy in adults:

• HIV infection (stages 2A-2B);
• Neuroinfections: serous meningitis and encephalitis, tick borelliosis (Lyme disease);
• viral hepatitis A, B, C, D;
• herpetic infection;
• cytomegalovirus infection;
• secondary immunodeficiencies associated with acute and chronic bacterial and fungal infections;
• chlamydial infections;
• rheumatic and systemic connective tissue diseases (rheumatoid arthritis, systemic lupus erythematosus);
• degenerative-dystrophic diseases of joints (including deforming osteoarthritis).

As part of complex therapy in children:

• viral hepatitis A, B, C, D;
• herpetic infection;
• HIV infection (stages 2A-2B).

Liniment

• herpetic infection of the skin and mucous membranes;
• treatment of urethritis and balanoposthitis with nonspecific and specific (gonorrhea, candidiasis, chlamydial and trichomonadal) etiology;
• treatment of nonspecific bacterial vaginitis and vaginosis;
• treatment of chronic periodontitis.

Forms of release

Tablets, covered with a shell, soluble in the intestine 0.15 g.

Solution for intravenous and intramuscular injection (injections in ampoules for injection) 125 mg / ml.

Liniment or ointment 5%.

Instructions for use and dosing regimen

Inside

Tsikloferon in the form of tablets take 1 time per day for 30 minutes before meals, without chewing.

Adults with herpetic infection drug prescribed for 4 tablets per reception for 1, 2, 4, 6, 8, 11, 14, 17, 20 and 23 days. The course of treatment is 40 tablets. Treatment is most effective when the first symptoms of the disease appear.

In the treatment of influenza and acute respiratory diseases, 4 tablets are prescribed for administration at 1, 2, 4, 6, 8 days. The course of treatment - 20 tablets. Treatment should be started with the first symptoms of infection. In case of severe disease, 6 tablets are taken at the first dose. If necessary, symptomatic therapy is also provided (antipyretic, analgesic, expectorant).

In chronic viral hepatitis B and C, the drug takes 4 tablets per reception for 1, 2, 4, 6, 8, 11, 14, 17, 20 and 23 days of treatment, and then, according to the supporting scheme, 4 tablets per reception every 3 day for 6 months. while preserving replicative and cytolytic activity up to 12 months. Combination with interferons and antiviral drugs is recommended.

In the complex therapy of intestinal infections, 2 tablets are taken per reception for 1, 2, 4, 6, 8, 11, 14, 17, 20 and 23 days. The course of treatment - 20 tablets.

In case of neuroinfections, 4 tablets are prescribed for 1, 2, 4, 6, 8, 11, 14, 17, 20 and 23 days and then, according to the supporting scheme, 4 tablets per reception every 3 days for 2.5 months. The course of treatment - 140 tablets.

In case of HIV infection (stages 2A-2B), the drug is prescribed for 1, 2, 4, 6, 8, 11, 14, 17, 20, 23 days, 4 tablets per reception and then support treatment with 4 tablets once every 3 day for 2.5 months. The course of treatment - 140 tablets. The repeated course is carried out in 2-3 weeks. after the end of the previous 2-3 times.

In immunodeficient conditions associated with chronic bacterial and fungal infections, 4 tablets are administered in the first 5 sessions on days 1, 2, 4, 6, 8 and 2 tablets in the following 5 sessions at 11, 14, 17, 20, 23 Treatment course - 30 tablets

Children Tsikloferon appointed according to the following basic scheme: at the age of 4-6 years - 150 mg (1 tablet), at the age of 7-11 years - 300 mg (2 tablets), over 12 years - 450 mg (3 tablets) at the reception 1 time per day. It is advisable to repeat the second course after 2-3 weeks. after the end of the first year.

When herpetic infection is taken at 1, 2, 4, 6, 8, 11, 14 days of treatment. The course of treatment can vary depending on the severity of the condition and the severity of clinical symptoms.

In case of influenza and acute respiratory viral infections, the drug is prescribed in age-related doses for 1, 2, 4, 6, 8, 11, 14, 17, 20, 23 days and then 1 every 3 days. The course of treatment is from 5 to 15 receptions, depending on the severity of the condition and the severity of the symptoms.

As a means of emergency non-specific prophylaxis of acute respiratory infections and influenza during the period of increased morbidity, the drug is prescribed at the indicated age doses for 1, 2, 4, 6, 8 days, then 5 more times with an interval of 72 hours (3 days).

In chronic forms of hepatitis B and / or C, the drug is prescribed at the indicated doses for 1, 2, 4, 6, 8, 11, 14 days and further 1 every 3 days for 6 months with preservation of replicative and cytolytic activity up to 12 months. Combination with interferons and antiviral drugs is recommended.

In acute intestinal infections, the drug is prescribed for 1, 2, 4, 6, 8, 11 days of treatment once a day. The course of treatment - 6-18 tablets.

In case of HIV infection (stages 2A-2B) the drug is taken according to the basic scheme for 1, 2, 4, 6, 8, 11, 14, 17, 20 day of therapy, then 1 every 3 days for 5 months.

In ampoules

Adults Cycloferon is administered intramuscularly or intravenously once a day according to the basic schedule: every other day. The duration of treatment depends on the disease.

With herpetic and cytomegalovirus infections, the drug is prescribed according to the basic scheme - 10 injections of 250 mg. The total dose of 2.5 g. Treatment is most effective at the onset of an exacerbation of the disease.

With neuroinfections, the drug is administered according to the basic scheme. The course of treatment - 12 injections of 250-500 mg in combination with etiotropic therapy. The total dose of 3-6 g. Repeated courses are conducted as needed.

With chlamydial infection treatment is carried out according to the basic scheme. The course of treatment 10 injections of 250 mg. The total dose of 2.5 g. Repeated course - after 10-14 days. It is advisable to combine Cycloferon with antibiotics.

In acute viral hepatitis A, B, C, D and mixed forms, the drug is administered by the basic scheme of 10 injections of 500 mg. The total dose is 5 g. With prolonged course, the repeated course is carried out 10-14 days later.

In chronic viral hepatitis B, C, D and mixed forms, the drug is administered by the basic scheme of 10 injections of 500 mg, then according to the supporting scheme 3 times per week. within 3 months in the complex therapy. It is recommended in combination with interferons and chemotherapy. Repeat the course in 10-14 days.

In HIV infection (stage 2A-2B), the drug is prescribed, according to the basic scheme, 10 injections of 500 mg and then on a maintenance schedule once every three days for 2.5 months. The course is repeated after 10 days.

In immunodeficient conditions, the course of treatment consists of 10 injections of IM in the basic scheme in a single dose of 250 mg. The total dose of 2.5 g. The repeated course is conducted after 6-12 months.

In rheumatic and systemic connective tissue diseases, 4 courses of 5 injections are prescribed according to the basic scheme, 250 mg with a break of 10-14 days. The doctor determines the need for a repeat course individually.

In degenerative-dystrophic diseases of joints, 2 courses of 5 injections of 250 mg are prescribed with a break of 10-14 days according to the basic scheme. The doctor determines the need for a repeat course individually.

Children Cycloferon is prescribed intramuscularly or intravenously once a day.The daily therapeutic dose is 6-10 mg / kg body weight.

In acute viral hepatitis A, B, C, D and mixed forms, 15 injections of the drug are carried out according to the basic scheme. With a prolonged course of infection, the course is repeated after 10-14 days.

In chronic viral hepatitis B, C, D, the drug is administered according to the basic schedule of 10 injections and then on a maintenance schedule 3 times a week for 3 months as part of complex therapy. Recommended use in combination with interferons and chemotherapy.

In HIV infection (stages 2A-2B), a course of 10 injections is prescribed according to the basic scheme and then on a supportive schedule once every 3 days for 3 months. Repeat the course after 10 days.

With herpetic infection, a course of 10 injections is carried out according to the basic scheme. If the replicative activity of the virus is maintained, the course of treatment is continued according to a supportive scheme with the administration of the drug once every 3 days for 4 weeks.

Liniment (ointment)

With herpetic infection liniment is applied a thin layer on the affected area 1-2 for 5 days. When genital herpes - intraurethral (intravaginal) instillations once a day for 5 ml for 10-15 days daily. Perhaps a combination of liniment with other anti-herpetic agents (both systemic and local).

In the treatment of nonspecific and candidiasis urethritis, intraurethral instillations are carried out in a volume of 5-10 ml, depending on the level of the urethra. When the upper part of the urethra is affected in men, the cannula of a syringe with liniment is inserted into the external opening of the urethra, then the opening is clamped for 1.5-3 minutes, after which the instillation solution is evacuated by gravity. After 30 minutes, the patient is advised to urinate. A longer exposure can lead to swelling of the urethral mucosa. The course of treatment is 10-14 days. In cases of lesions of the posterior urethra, the area of ​​the seminal glands, intraurethral instillations are applied through the catheter in a volume of 5-10 ml of the drug for 10-14 days every other day (for a course of 5-7 instillations).

In the treatment of urethritis specific etiology - combined use of intra-urethral instillations of Cycloferon with specific antimicrobial drugs according to traditional schemes.

With balanoposthitis, the penis head and foreskin should be treated with Cyclofiron liniment once a day (1/2 vial or 5 ml tubes) for 10-14 days.

With the treatment of candidal vaginitis, nonspecific vaginitis (endocervicitis) and bacterial vaginosis, it is possible to use the drug both in the form of monotherapy and in the course of complex treatment. Apply intravaginal instillations of the drug for 5-10 ml, for 10-15 days, 1-2 times a day. In parallel, in the case of combined damage to the vaginal mucosa and urethra, it is advisable to use intravaginal and intra-urethral instillations in the volume (5 ml daily for 10-14 days). It is possible to apply tampons impregnated with liniment.

In chronic forms of disease, the drug is well combined with the use of official medicines (vaginal tablets, candles).

To use intravaginally, open the tube, pierce the membrane with a disposable needle with a syringe (5 ml volume), collect liniment, remove and discard the needle. Fill the filled syringe in the prone position in the vagina and squeeze the liniment with the help of the piston. If there is a vaginal applicator in the package: pierce the tube membrane, screw the applicator to the stop on the tube opening. Press the liniment into the cavity of the applicator until the entire piston is pushed out.The filled applicator should be removed from the tube opening, inserted into the vagina and squeezed out the liniment with the help of a piston. To prevent free evacuation of the drug, the entrance to the vagina is swabbed with a small sterile cotton swab for 2-3 hours.

In the treatment of chronic periodontitis, before application of liniment, it is advisable to wash the periodontal pockets with an antiseptic, then apply liniment with a cotton swab in the volume of 1.5 ml (1/3 tube) to the gum with the application method (do not rub) 1-2 times a day at intervals of 10-12 hours. Duration therapy 12-14 days.

For all indications, if necessary, you can repeat the course of treatment with Cycloferon after 14 days.

Side effect

• allergic reactions.

Contraindications

• cirrhosis of the liver in the stage of decompensation;
• children under 4 years;
• pregnancy;
• lactation period (breastfeeding);
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The drug is contraindicated for use in pregnancy and lactation (breastfeeding).

special instructions

In cases of thyroid gland diseases, the use of Cycloferon should be carried out under the control of the endocrinologist.

In the treatment of influenza and SARS, in addition to Cycloferon therapy, symptomatic therapy should be given.

Impact on the ability to drive vehicles and manage mechanisms

Cycloferon does not affect the ability to drive vehicles.

Drug Interactions

Cycloferon is compatible with all medicines used in the treatment of these diseases (including interferons and chemotherapeutic drugs).

Cycloferon enhances the action of interferons and nucleoside analogues.

When combined, Cycloferon reduces the side effects of chemotherapy and interferon therapy.

Analogues of the drug Cycloferon

Structural analogs for the active substance:

• Meglumine acridon acetate.

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