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Clomiphen - instructions for use, analogs, reviews and release forms (tablets 50 mg) of the drug for infertility and stimulation of ovulation in IVF in women and men. Composition and consequences for pregnancy

Clomiphen - instructions for use, analogs, reviews and release forms (tablets 50 mg) of the drug for infertility and stimulation of ovulation in IVF in women and men. Composition and consequences for pregnancy

In this article, you can read the instructions for using the drug Clomiphene. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Klomifen in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Clomifene in the presence of existing structural analogues. Use to treat infertility and stimulate ovulation in IVF in women and men, as well as the consequences of taking in pregnancy and breast-feeding. Composition of the preparation.

 

Clomiphene - stimulant of gonadotropin production.Means with anti-estrogenic and estrogenic activity. Has a non-steroidal structure that is close to chlorotriazine. It is believed that the action of clomiphene is due to specific binding to the estrogen receptors of the hypothalamus and pituitary gland, which increases the secretion of gonadotropic hormones in the pituitary gland. This, in turn, stimulates the maturation and endocrine activity of the follicle in the ovary, as well as the subsequent formation and stimulation of the function of the yellow body. In high doses inhibits the secretion of gonadotropins. Does not possess gestagenic and androgenic activity.

 

Composition

 

Clomiphene citrate + auxiliary substances.

 

Pharmacokinetics

 

Clomiphene is rapidly absorbed from the digestive tract. Undergoes intestinal-hepatic recirculation. It is excreted mainly with feces - 42% and about 8% with urine.

 

Indications

  • to stimulate ovulation infertility due to secondary ovarian hypofunction, mainly due to functional hypothalamic-pituitary disorders;
  • functional uterine bleeding;
  • secondary amenorrhea or pronounced oligomenorrhoea;
  • polycystic ovary syndrome (of the Stein-Levental type);
  • androgen insufficiency;
  • Chiari-Frommel syndrome;
  • in men - oligospermia.

 

Forms of release

 

Tablets 50 mg.

 

Instructions for use and reception scheme

 

Inside.

 

To stimulate ovulation administered at 50 mg 1 time per day at bedtime, starting with day 5 of the menstrual cycle, for 5 days (in the absence of the cycle - at any time). In the absence of effect (ovulation does not develop within 30 days) increase the dose to 150 mg per day or extend the course to 10 days. Heading dose should not exceed 1, the development of ovulation is determined by the presence of a biphasic basal body temperature, the mean cyclic enhance production of LH, increase serum Progesterone during the luteal phase of the probable average or menstrual bleeding women with amenorrhea. If ovulation takes place, and there is no pregnancy, then you should repeat the same dose at the next treatment course. If, after probably held ovulation was no menstrual bleeding, should take into account the possibility of pregnancy, and before a new course of treatment is necessary to eliminate this possibility.

 

Men are prescribed 50 mg 1-2 times a day for 3-4 months (systematic monitoring of the spermogram is necessary).

 

Side effect

  • increased excitability;
  • fatigue;
  • dizziness;
  • insomnia;
  • Strong headache;
  • increase in body weight;
  • polyuria;
  • pollakiuria;
  • increased sweating;
  • an increase in the size of the ovaries or ovarian cysts;
  • pain in the appendages of the uterus;
  • profuse menstruation;
  • feeling of heaviness in the epigastrium;
  • flatulence;
  • nausea, vomiting;
  • hives;
  • allergic dermatitis;
  • fits of fever;
  • heaviness in the chest;
  • insignificant reversible alopecia;
  • violation of visual acuity.

 

Contraindications

  • impaired liver function;
  • visual impairment (including anamnesis);
  • ovarian cysts;
  • neoplasms (tumors);
  • primary hypofunction of the pituitary gland;
  • bleeding of unknown origin;
  • pregnancy;
  • lactation;
  • increased sensitivity to clomiphene.

 

Application in pregnancy and lactation

 

Clomiphene is contraindicated in pregnancy and lactation.

 

Use in children

 

Data on the use of the drug in children are absent.

 

special instructions

 

Applied only with preserved function of the ovaries. When a symptom of ovarian hyperstimulation or other side effects appears on the background of treatment, correction of the dosing regimen is necessary.

 

Do not use in women who have contraindications to pregnancy.

 

Impact on the ability to drive vehicles and manage mechanisms

 

Clomiphene should not be used in patients whose activities are associated with the need for concentration and high speed of psychomotor reactions.

 

Drug Interactions

 

Currently, the drug interaction is not described.

 

Compatible with preparations of gonadotropic hormones.

 

Analogues of the drug Klomifen

 

Structural analogs for the active substance:

  • Clomid;
  • Clostilbite;
  • Serofen;
  • Serpafar.

 

Analogues on the pharmacological group (funds for the treatment of female infertility):

  • Aberghin;
  • Biel;
  • Bromocriptine;
  • Bromergon;
  • Buserelin;
  • Buserelin depot;
  • Buserelin Long FS;
  • Gonadotropin is chorionic for injection;
  • Danazol;
  • Dianodiol;
  • Danol;
  • Decapeptil;
  • Diferelin;
  • Duphaston;
  • Clomid;
  • Clostilbite;
  • Luveris;
  • Mastodinone;
  • Menogon;
  • Menopur;
  • Metovit;
  • Novofen;
  • Non Ovlon;
  • Organutran;
  • Pergonal;
  • Pyrogenal;
  • Pregnil;
  • Pureghon;
  • Serofen;
  • Serpafar;
  • Sinestrol;
  • Tamoxifen;
  • Horagon;
  • Humegon;
  • Cigapan;
  • Egestenol;
  • Ethinyl estradiol.

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