Itomed - instructions for use, analogs, reviews and release forms (50 mg tablets) of a medicament for the treatment of flatulence, heartburn, nausea, or vomiting in adults, children and during pregnancy. Composition

In this article, you can read the instructions for using the drug Itomed. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Itomed in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Itomed in the presence of existing structural analogues. Use to treat flatulence, heartburn, nausea, or vomiting in adults, children, as well as during pregnancy and lactation.Composition of the preparation.

Itomed - strengthens the motility of the gastrointestinal tract due to antagonism with D2-dopamine receptors and inhibition of acetylcholinesterase. Activates the release of acetylcholine, inhibits its destruction.

Has antiemetic effect due to interaction with D2-receptors, located in the trigger zone. Causes a dose-dependent suppression of emesis caused by apomorphine.

Activates propulsive motility of the stomach due to antagonism with D2-receptors and dose-dependent inhibition of acetylcholinesterase activity.

Has a specific effect on the upper gastrointestinal tract, accelerates transit through the stomach, improves its emptying. Has no effect on serum concentrations of gastrin.

Composition

Itopride hydrochloride + excipients.

Pharmacokinetics

Quickly and well absorbed in the digestive tract. The relative bioavailability of the drug is 60%. At repeated admission to 50-200 mg 3 times a day for 7 days, pharmacokinetics is linear in nature, cumulation is minimal. It binds to plasma proteins (mainly albumin) by 96% with alpha-1-acid glycoprotein by less than 15%. It is actively distributed in tissues and is found in high concentrations in the kidneys, the small intestine, the liver, the adrenal glands, and the stomach.In therapeutic doses, it penetrates insignificantly into the brain and spinal cord, into breast milk. Metabolised in the liver under the influence of flavin-dependent monooxygenase. Three metabolites have been identified, one of which exhibits little activity: 2-3% of the activity of itopride. It is excreted by the kidneys.

Indications

• symptomatic treatment of functional non-ulcer dyspepsia (chronic gastritis): flatulence, gastralgia, a feeling of discomfort in the epigastric region, anorexia, heartburn, nausea, vomiting.

Forms of release

The tablets covered with a cover of 50 mg.

Instructions for use and dosing regimen

Inside, before meals, 1 tablet 3 times a day. The daily dose of the drug is 3 tablets (150 mg).

In elderly patients, the dose is reduced. If the drug was not taken on time, then in the future it should be taken at regular intervals. It is not recommended to take in a double dose to compensate for missed.

Side effect

• leukopenia, thrombocytopenia;
• gynecomastia;
• hyperprolactinemia;
• increased salivation;
• nausea;
• diarrhea, constipation;
• jaundice;
• pain in the epigastric region;
• headache;
• sleep disturbance;
• irritability;
• dizziness;
• tremor;
• hives;
• anaphylactic shock.

Contraindications

• gastrointestinal bleeding;
• mechanical obstruction and perforation of the gastrointestinal tract;
• deficiency of lactase;
• lactose intolerance;
• glucose-galactose malabsorption;
• children's age (up to 16 years);
• pregnancy;
• lactation period;
• hypersensitivity to tesentropium or any auxiliary component of the drug.

Application in pregnancy and lactation

It is contraindicated in pregnancy.

When taking the drug in therapeutic doses, it appears that it hardly penetrates into breast milk, so you should stop taking the drug during lactation.

Use in children

Contraindicated in children under 16 years.

Application in elderly patients

In elderly patients, the dose is reduced.

special instructions

Caution is prescribed for patients taking cholinesterase inhibitors and m-cholinomimetics; as well as elderly patients with reduced liver and kidney function.

When symptoms of galactorrhea and gynecomastia manifest, interrupt or stop treatment altogether.

In the treatment of primary biliary cirrhosis, transient decompensation of liver cirrhosis can occur, which disappears after drug withdrawal.

Impact on the ability to drive vehicles and manage mechanisms

During the treatment period, it is necessary to refrain from driving motor vehicles and engage in potentially dangerous activities that require increased concentration, attention and speed of psychomotor reactions.

Drug Interactions

Accelerates the absorption of other drugs.

Prokinetic effect of the drug does not change under the influence of drugs that reduce the acidity of gastric juices (cimetidine, ranitidine, tehrrenone, cetraxate).

M-holinoblokatory lower efficiency of Itomed.

The cholinergic effect of tytopride may increase with simultaneous administration of m-cholinomimetics, as well as cholinesterase inhibitors.

Analogues of the drug Itomed

Structural analogs for the active substance:

• Ganaton;
• Itopra.

Analogues on the curative effect (remedies for the treatment of nausea and vomiting):

• Aviamarin;
• Almol;
• Bactistatin;
• Beviplex;
• Betaver;
• Betagistin;
• Betaserc;
• Bonin;
• Haloperidol;
• Ganaton;
• Glucosterol;
• Decadron;
• Domperidone;
• Dramina;
• Zofran;
• Iberogast;
• Yonosterol;
• Kinedryl;
• Citril;
• Latran;
• Lemodus;
• Laurafen;
• Metamol;
• Metovit;
• Metoclopramide;
• Motilac;
• Motilium;
• Motion;
• Navoban;
• Nobrethum;
• Odeston;
• Sturgeon
• Papaverine;
• Passion;
• Perinorm;
• Pipolphen;
• Raglan;
• Riabal;
• Trimedate;
• Triftazine;
• Tropindol;
• Hofitol;
• Cerucal;
• Cinnaron;
• Emend;
• Emeset;
• Emetron;
• Etaperazine.

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