Stresam - instructions for use, reviews, analogs and forms of release (capsules or tablets 50 mg) medications for the treatment of anxiety, fear and irritability in adults, children and pregnancy. Composition and interaction with alcohol

In this article, you can read the instructions for using the drug Stresam. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Stresama in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Stresama in the presence of existing structural analogues.Use to treat anxiety, fear and irritability in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Stresam - anxiolytic (tranquilizer). Belongs to benzoxazine derivatives.

As an anxiolytic drug etifoksin (the active substance of the drug Stresam) has an autonomous regulatory action. In studies in rats and mice, it was shown that the anxiolytic activity of etifoxine is due to a double mechanism of its action (direct and indirect) on GABA-A receptors, which improves GABA-ergic impulse transmission. In direct exposure to the GABA-A receptor by allosteric modulation, etifoxine binds predominantly to the beta2 or beta3 receptor subunits; studies have shown that etifoksin binds to the GABA-A receptor at sites other than the binding site for benzodiazepines. Indirect effects are provided by increasing the synthesis of neurosteroids (by activation of the mitochondrial translocative protein), such as allopregnanolone, which is also a positive allosteric modulator of GABA-A receptor.

Does not cause addiction and withdrawal symptoms.

Composition

Ethifoxine hydrochloride + excipients.

Pharmacokinetics

Rapidly absorbed from the digestive tract, rapidly metabolized in the liver until the formation of several metabolites. One of the metabolites (diethylethoxifin) is active and its half-life is about 20 hours. Penetrates through the placental barrier. Time to reach the maximum concentration in the blood - 2-3 hours, half-life - about 6 hours. It is excreted mainly with urine in the form of metabolites, and also in unchanged form in small amounts. Also excreted with bile.

Indications

• to eliminate anxiety, fear, internal tension, increased irritability, decreased mood (including against somatic diseases, especially cardiovascular nature).

Forms of release

Capsules 50 mg (sometimes mistakenly called pills).

Instructions for use and dosing regimen

Dose and duration of treatment the doctor determines individually, depending on the patient's condition.

The drug is administered internally, usually 50 mg (1 capsule) 3 times a day or 100 mg (2 capsules) 2 times a day. The course of treatment usually ranges from a few days to 4-6 weeks.

Capsules are washed down with a small amount of water.

Side effect

• slight drowsiness, which appears in the first days of admission and usually disappears independently during the treatment;
• maculopapular rashes;
• erythema multiforme;
• itching;
• edema of the face;
• hives;
• angioedema;
• anaphylactic shock;
• syndrome of drug-induced hypersensitivity with eosinophilia;
• Stevens-Johnson syndrome;
• leukocytoclastic vasculitis;
• cytolytic hepatitis;
• metrorrhagia in women taking oral contraceptives;
• lymphocytic colitis.

Contraindications

• shock states;
• myasthenia gravis;
• galactosemia, glucose malabsorption syndrome and galactose, lactase insufficiency;
• children and adolescents under 18;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The use of the drug during pregnancy and during breastfeeding is not recommended.

During pregnancy, which occurred during treatment with Strezam, the patient should consult a doctor about the continuation of treatment.

Use in children

It is not recommended to use the drug in children and adolescents under the age of 18 years.

special instructions

Strezam contains lactose, which should be taken into account when administering the drug to patients with galactosemia, glucose malabsorption syndrome and galactose, and also in the case of lactase deficiency.

When skin or allergic reactions occur, as well as complications from the liver, the drug should be stopped.

If you miss the drug, do not double the dose the next time you take it.

The dosage prescribed by the doctor should not be exceeded.

It is not recommended to take the drug while drinking alcoholic beverages.

Impact on the ability to drive vehicles and manage mechanisms

Due to the risk of drowsiness, vehicle management should be avoided and activities requiring increased attention, for example, management of various mechanisms.

Drug Interactions

Stresam potentiates the effect of drugs that depress the central nervous system (including opioid analgesics, barbiturates, hypnotics, antihistamines, neuroleptics).

Stresam increases the effect of ethanol (alcohol).

Analogues of the drug Stresam

Strezam has no structural analogs for the active substance. The preparation has a unique composition according to the main active ingredient.

Analogues on the pharmacological group (anxiolytics):

• Adaptol;
• Alzolam;
• Alprazolam;
• Anvifen;
• Apaurin;
• Atarax;
• Afobazol;
• Bromazep;
• Bromazepam;
• Bromide;
• Valium Rosh;
• Hydroxysine;
• Grandaxin;
• Diazepabene;
• Diazepam;
• Diazepec;
• Diamidazepam;
• Zolomax;
• Ipronal;
• Kassadan;
• Xanax;
• Xanax retard;
• Lexotan;
• Librax;
• Loram;
• Laurafen;
• Mebicar;
• Mezapam;
• Mexiprim;
• Mexicin;
• Miolastane;
• Napoton;
• Neurophasole;
• Nozepam;
• Noophen;
• Oxazepam;
• Radepur;
• Relanium;
• Seduxen;
• Sibazon;
• Tazepam;
• Tenoten;
• Tofizopam;
• Tranxen;
• Fesipam;
• Phenazepam;
• Fenibut;
• Helex;
• Elenium;
• Elzepam.

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