Fluorouracil - instructions for use, reviews, analogs and formulations (solution for intravascular and intracavitary injection in ampoules) drugs for the treatment of skin, stomach, intestinal cancer in adults, children and pregnancy

In this article, you can read the instructions for using the drug Fluorouracil. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Fluorouracil in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogs of fluorouracil in the presence of existing structural analogues.Use to treat skin, stomach, intestine and other cancers of cancer in adults, children, as well as during pregnancy and breast-feeding.

Fluorouracil antitumor agent from the group of antimetabolites. Inhibits the process of cell division by blocking the synthesis of DNA (due to inhibition of the enzyme activity of thymidylate synthetase) and the formation of structurally deficient RNA (due to the introduction of fluorouracil into its structure).

Composition

Fluorouracil + excipients.

Pharmacokinetics

Penetrates through the blood-brain barrier (BBB). Rapidly metabolized in tissues with the formation of an active metabolite - fluorouridine monophosphate. Catabolic cleavage occurs in the liver. It is released through the respiratory tract - 60-80% in the form of carbon dioxide, and also by the kidneys - 7-20% unchanged.

Indications

skin cancer;
colon cancer;
rectal cancer;
mammary cancer;
stomach cancer;
liver cancer;
uterine cancer;
ovarian cancer;
cancer of the bladder.

Forms of release

Solution for intravascular and intracavitary administration (injections in ampoules for injection).

Instructions for use and dosing regimen

Established individually, depending on the indications and stage of the disease, the state of the hematopoiesis system, the scheme of antitumor therapy.

Side effect

diarrhea;
stomatitis;
esophagitis;
nausea, vomiting;
anemia, leukopenia, thrombocytopenia;
hemorrhage;
ataxia;
optic neuritis;
headache;
nystagmus;
visual impairment;
photophobia;
euphoria;
confusion of consciousness;
disorientation;
myocardial ischemia;
angina pectoris;
thrombophlebitis;
azoospermia;
amenorrhea;
alopecia;
dermatitis;
hyperpigmentation;
hives;
bronchospasm.

Contraindications

peptic ulcer of the stomach and duodenum in the phase of exacerbation;
bleeding of any location;
a high risk of gastrointestinal bleeding;
severe anemia, leukopenia, thrombocytopenia;
pregnancy;
breast-feeding.

Application in pregnancy and lactation

Fluorouracil is contraindicated in pregnancy. If necessary, use during lactation should stop breastfeeding.

Women of childbearing age should apply reliable contraceptive methods during fluorouracil therapy.

In experimental studies, teratogenic and embryotoxic effects of fluorouracil have been established.

Use in children

Not indicated.

special instructions

It is not recommended to use fluorouracil in patients with chickenpox (including recently transferred or after contact with the diseased), herpes zoster and other acute infectious diseases.

Caution is used fluorouracil in patients who have previously received cytotoxic drugs or radiation therapy.

Do not recommend the vaccination of patients and their families on the background of therapy.

If violations of the liver or kidney function, lower doses should be used.

When stomatitis or diarrhea occurs, treatment should be stopped until these symptoms disappear.

Before the start of chemotherapy and in the process of fluorouracil therapy, the peripheral blood picture should be monitored, the laboratory parameters of the liver and kidney function should be monitored.

The most significant decrease in the number of leukocytes is usually observed between the 9th and 14th day of the first course of therapy, but delayed myelodepression (up to 20 days) is possible. The normalization of the number of leukocytes occurs by the 30th day.

In experimental studies, a carcinogenic and mutagenic effect of fluorouracil has been established.

Drug Interactions

With simultaneous use with other drugs that cause myelodepression, additive oppression of bone marrow function is possible; with Interferon alpha-2b - an increase in the initial concentration of fluorouracil in the blood plasma and a decrease in fluorouracil clearance.

In patients with colorectal cancer, concomitant use with Metronidazole may increase the toxicity of fluorouracil.

In the case of prior use of fluorouracil, the cytotoxic action of Paclitaxel may be inhibited.

In the case of prior application of cimetidine, an increase in the concentration of fluorouracil in the blood plasma is possible.

With the simultaneous use with allopurinol, methotrexate, a possible change in the antitumor effect of fluorouracil; with calcium folinate - may enhance the antitumor and toxic effects of fluorouracil, especially on the gastrointestinal tract.

Analogues of the drug Ftoruracil

Structural analogs for the active substance:

5 Fluorouracil Ebwee;
Fyvoflu;
Fluoro uracil Roche;
Fluorouracil LENS;
Fluorouracil RONC;
Fluorouracil Teva;
Fluorouracil injection 5%.

If there are no analogues of the medication for the active substance, you can go to the links below for diseases, from which the corresponding drug helps, and to look at the available analogs for therapeutic effects.

Used for the treatment of diseases: cancer, oncology, tumor, skin cancer, stomach cancer, colon cancer, rectal cancer, mammary cancer, liver cancer, uterine cancer, ovarian cancer, bladder cancer