Pangrol - instructions for use, analogs, reviews and release forms (capsules or tablets 10 000 units and 25 000 units) of the drug for the treatment of pancreatitis, cystic fibrosis, enzyme deficiency in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Pangrol. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Pangrol in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Pangrol in the presence of existing structural analogues. Use for the treatment of pancreatitis, cystic fibrosis, enzyme deficiency in adults, children, as well as in pregnancy and lactation. Composition of the preparation.

Pangrol - active substance of the drug is pancreatin, which is a powder from the pancreas of pigs. Enzymes that are part of pancreatin, contribute to the breakdown of fats, carbohydrates and proteins coming from food. Pancreatin, providing proteolytic, amylolytic and lipolytic action, compensates for the enzymatic pancreatic insufficiency, improves the functional state of the gastrointestinal tract, normalizes the digestive process.

Composition

Pancreatin + auxiliary substances.

Pharmacokinetics

Gelatin capsules of the drug Pangrol quickly dissolve in the stomach, releasing mini-tablets, covered with enteric-acid (acid-resistant) membrane. Thus, the enzymes remain protected from inactivation in the acidic environment of the stomach. The form of the preparation provides mixing of mini-tablets with intestinal contents and uniform distribution of enzymes. The dissolution of the mini-tablet shell and activation of the enzymes occurs with a neutral or slightly alkaline pH in the small intestine. Pancreatin is not absorbed into the digestive tract, it is excreted with deadly masses.

Indications

Substitution therapy of insufficiency of exocrine pancreatic function in adults and children under the following conditions:

• chronic pancreatitis;
• cystic fibrosis;
• pancreas cancer;
• condition after surgery on the pancreas and stomach (complete or partial resection of the organ);
• after irradiation of the digestive tract, accompanied by a violation of food digestion, flatulence, diarrhea (as part of combination therapy);
• narrowing of the duct of the pancreas (for example, because of a tumor or gallstones);
• Syndrome Shvahmana-Diamond;
• subacute pancreatitis;
• Other diseases accompanied by exocrine pancreatic insufficiency.

Relative enzyme failure in the following conditions and situations:

• GI disorders of a functional nature;
• with acute intestinal infections,
• irritable bowel syndrome;
• the use of indigestible vegetable or fatty foods.

Preparation for X-ray and ultrasound examinations of the abdominal cavity organs.

Forms of release

Capsules enteric soluble 10 000 units and 25 000 units (sometimes mistakenly called tablets).

Instructions for use and reception scheme

The dose of Pangrol is selected individually depending on the severity of the disease, as well as the volume and composition of the food taken.

Unless otherwise indicated, adults are advised to take 2-4 capsules of Pangrol 10000 or 1-2 capsules of Pangrol 25,000 during each meal, swallowing whole capsules (not chewed), with a sufficient amount of liquid (for example, a glass of water).

If a whole patient capsule is difficult to take (for example, in young children or elderly patients), you can pour its contents, for example, into a glass, opening the capsule by separating the lid from the body, and then taking the contents (mini tablets) liquid or add to liquid food that does not require chewing (for example, apple puree or fruit juice). Mixture of mini-tablets with food or liquid is not to be stored (taken immediately after preparation).

An increase in the dose of the drug should be carried out only under the supervision of the doctor, while focusing on the dynamics of symptoms (for example, reduction of steatorrhea, easing of pain in the abdomen).

The daily dose of enzymes is 15,000-20,000 lipase units.per 1 kg of body weight, exceed is not recommended.

The duration of the course of treatment is determined by the doctor and depends on the course of the disease.

For children, the dosing regimen and the duration of treatment are determined by the doctor, depending on the severity of the disease and the composition of food at a rate of 500-1000 lipase units. per 1 kg of the child's body weight for each meal.

In cystic fibrosis, the dose of Pangrol drug depends on the body weight and should be at the beginning of treatment 1000 lipase units. per 1 kg for each meal for children under 4 years old, and 500 lipase units. per 1 kg during each meal for children over 4 years. The dose of the drug should be selected individually, depending on the severity of the disease, under the control of the steatorrhea and the support of an optimal diet. In most patients, the dose should not exceed 10,000 lipase units. per 1 kg per day or 4000 lipase units. for 1 g of consumed fat.

Side effect

• nausea, vomiting;
• bloating;
• pain in the abdomen;
• diarrhea;
• rash;
• itching;
• hives.

Contraindications

• acute pancreatitis;
• exacerbation of chronic pancreatitis;
• increased sensitivity to pancreatin of porcine origin or other components of the drug.

Application in pregnancy and lactation

Clinical data on the treatment of pregnant women with drugs containing pancreatic enzymes are absent. In the course of studies on animals, no absorption of pancreatic enzymes of porcine origin has been detected, therefore, toxic effects on reproductive function and fetal development are not expected.

The use of Pangrol during pregnancy is possible if the expected benefit for the mother exceeds the possible risk to the fetus

Based on animal studies, during which no adverse effects of pancreatic enzymes have been identified, no adverse effect of the drug on the baby through breast milk is expected. During breastfeeding, you can take pancreatic enzymes.

Use in children

For children, the dosing regimen and the duration of treatment are determined by the doctor, depending on the severity of the disease and the composition of food at a rate of 500-1000 lipase units. per 1 kg of the child's body weight for each meal.

special instructions

In patients with cystic fibrosis who received high doses of pancreatin preparations, iliac, blind and colon strictures (fibrosing colonopathy) are described.As a precautionary measure, when unusual symptoms or changes in the nature of the symptoms of the underlying disease appear, a medical examination is necessary to exclude the defeat of the colon, especially if the drug is administered at a dose of more than 10,000 lipase units. per 1 kg of body weight per day.

Impact on the ability to drive vehicles and manage mechanisms

Pangrol does not affect the performance of potentially hazardous activities requiring special attention and speed of response.

Drug Interactions

There were no studies on the interaction.

Analogues of the drug Pangrol

Structural analogs for the active substance:

• Gastenorm forte;
• Creon;
• Mezim;
• Mezim forte;
• Mikrazim;
• PanziKam;
• Panzim Forte;
• Panzinorm;
• Penzinorm forte 20 000;
• Pancreatym;
• Pancreatin;
• Pancreatin forte;
• Pancrelipase;
• Pantcitrate;
• Penzital;
• Festal N;
• Enzistal P;
• Hermitage.

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