Aktiferrin - instructions for use, analogs, reviews and release forms (capsules or tablets Compositum, drops, syrup), a drug for the treatment of iron deficiency in adults and children (including infants and newborns) and pregnancy

In this article, you can read the instructions for using the drug Actyferrin. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Actyferrin in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Actiferrin in the presence of existing structural analogues.Use to treat iron deficiency and anemia in adults, children (including infants and newborns), as well as during pregnancy and lactation. Composition of the preparation.

Actyferrin - an iron preparation. Iron is necessary for the life of the body: it is part of hemoglobin, myoglobin, a number of enzymes; reversibly binds oxygen and participates in a number of oxidation-reduction reactions; stimulates erythropoiesis. The alpha-amino acid serine included in the composition of Aktiferrin promotes more efficient absorption of iron and its entry into the systemic bloodstream, which leads to a rapid restoration of the normal iron content in the body. The inclusion of serine in the alpha-amino acid makes it possible to reduce the dose of iron, providing a better tolerance of the drug.

When using the drug Aktiferrin, the iron deficiency in the body is rapidly replenished, which leads to a gradual regression of clinical (weakness, fatigue, dizziness, tachycardia, tenderness and dry skin) and laboratory symptoms of anemia.

The compositum alpha-aminocampite-d, l-serine, which is part of Aktiferrin, promotes more efficient absorption of iron and its intakein the systemic bloodstream, leading to a rapid recovery of its normal content in the body. This allows you to reduce the dose of iron, providing better tolerability and excluding acute toxicity of the drug.

Pregnant women who took Actyferrin Compositum from the 22nd week of pregnancy, by the 30th week of pregnancy, found a higher content of iron in the blood than pregnant women who did not take the drug. In newborns, the iron content in the blood is also higher in those cases when their mothers took Aktiferrin compositum during pregnancy.

Folic acid, which is part of Aktiferrin compositum, takes part in the synthesis of amino acids, nucleotides, nucleic acids; is necessary for normal erythropoiesis. During pregnancy, it performs a certain protective function in relation to the action of teratogenic factors.

Composition

Iron sulfate + D, L-serine + excipients (Actyferrin).

Iron sulphate + D, L-serine + folic acid + excipients (Aktiferrin Compositum).

Pharmacokinetics

After ingestion, iron is absorbed completely completely from the digestive tract.There is a correlation between the degree of iron deficiency and the amount of iron absorbed into the systemic bloodstream (the higher the iron deficiency, the better the absorption). It is excreted in urine, feces and sweat.

Indications

• iron deficiency anemia of various etiologies;
• latent lack of iron in the body, associated with excessive loss of iron (bleeding, including uterine, permanent donation) or with increased need for it (pregnancy, lactation, period of active growth, malnutrition, chronic gastritis with secretory insufficiency, condition after stomach resection, stomach and duodenal ulcer, decrease in body resistance in adults and children with infectious diseases, tumors);
• treatment of iron deficiency anemia with concomitant deficiency of folic acid (for Actyferrin Compositum).

Forms of release

Capsules (sometimes mistakenly called pills).

Drops for oral administration.

Syrup.

Capsules Aktiferrin Compositum.

Instructions for use and dosage

Capsules

For adults and adolescents, the drug is preferably administered in the form of capsules, at the beginning of therapy - 1 capsule 2-3 times a day.With a poor tolerance of the drug, the dose is gradually reduced to the maximum tolerable. The duration of therapy (before the normalization of hemoglobin) is increased. Children over 6 years of age Aktiferrin appoint 1 capsule per day.

The drug is taken orally immediately before meals or during meals. Capsules are not chewed, washed down with enough water.

Treatment with the drug is continued for at least 8-12 weeks after achieving normal values ​​of serum iron and hemoglobin, appointing a maintenance dose.

Drops

The daily dose is set at the rate of 5 drops per 1 kg of body weight, the frequency of reception is 2-3 times a day.

Breast children: the average dose is 10-15 drops 3 times a day.

Children of preschool age: the average dose is 25-35 drops 3 times a day.

Children of school age: the average dose - 50 drops 3 times a day.

To open the bottle, press the cap down and simultaneously turn in the direction of the arrow. After applying the medicine, the cap should be installed and tightened (prevents access for children).

Drops and syrup are taken with a small amount of liquid (fruit tea or water).

Syrup

Children older than 2 years are preferable to prescribe the drug in the form of a syrup. The daily dose is 5 ml per 12 kg of body weight. The average dose for preschool children is 5 ml 1-2 times a day; for children of school age - 5 ml 2-3 times a day.

The drug is taken orally immediately before meals or during meals.

Drops and syrup are taken with a small amount of liquid (fruit tea or water).

Treatment with the drug is continued for at least 8-12 weeks after achieving normal values ​​of serum iron and hemoglobin, appointing a maintenance dose.

Capsules Aktiferrin Compositum

Capsules Aktiferrin compositum is taken orally during a meal, without chewing and washing down with a sufficient amount of water.

If the physician does not prescribe a different dosage, then follow the instructions given below.

Daily dose: 1 capsule. Depending on the severity of the disease, the dose can be increased to 2-3 capsules per day.

After reaching the normal values ​​of serum iron and hemoglobin, the drug is continued for at least 4 weeks.

Side effect

• complaints from the gastrointestinal tract (flatulence, constipation, diarrhea);
• loss of appetite;
• bitter taste in the mouth;
• redness of the skin;
• itching;
• rash;
• headache;
• dizziness;
• weakness;
• spasms of bronchial musculature;
• nausea;
• irritability;
• excitability;
• sleep disorder with nightmares;
• in patients with epilepsy, convulsive seizures may become more frequent;
• toothache;
• a sore throat;
• a feeling of pressure behind the sternum.

Contraindications

• hemolytic and aplastic anemia;
• hemosiderosis, hemochromatosis;
• sideroahrestic anemia, anemia in lead poisoning, thalassemia;
• Other types of anemia, not due to iron deficiency in the body;
• late porphyria of the skin;
• chronic hemolysis;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

With the established iron deficiency in the body during pregnancy and lactation (breastfeeding), the use of Actiferrin is considered to be justified and safe.

Use in children

For adolescents, the drug is preferably administered as capsules, at the beginning of therapy - 1 capsule 2-3 times per day. With a poor tolerance of the drug, the dose is gradually reduced to the maximum tolerated. The duration of therapy (before the normalization of hemoglobin) is increased.Children over 6 years of age Aktiferrin appoint 1 capsule per day.

Children older than 2 years are preferable to prescribe the drug in the form of a syrup. The daily dose is 5 ml / 12 kg of body weight. The average dose for preschool children is 5 ml 1-2 times a day; for children of school age - 5 ml 2-3 times a day.

Newborns, infants and young children Actiferrin is administered in the form of drops. The daily dose is set at the rate of 5 drops per 1 kg of body weight; multiplicity of appointment - 2-3 times a day. The average dose for infants is 10-15 drops 3 times a day; for children of preschool age - 25-35 drops 3 times a day; for children of school age - 50 drops 3 times a day.

special instructions

Be wary appoint patients with gastric ulcer and duodenal ulcers, inflammatory bowel disease (enteritis, diverticulitis, ulcerative colitis, Crohn's disease), chronic alcoholism, allergies, asthma, hepatitis, hepatic and renal failure, rheumatoid arthritis, blood transfusion .

Care must be taken when assigning Aktiferrina in the form of a syrup and drops of diabetics since the product contains carbohydrates: 1 teaspoon of syrup contains 1.8 g of glucose,and 18 drops (1 ml) - 64 mg, which is equivalent to 0.15 XE and 0.0053 XE, respectively.

Aktiferrin is not washed down with black tea, coffee, milk to prevent the absorption of iron. In addition, a decrease in absorption can be caused by solid food, bread, raw cereals, dairy products, eggs. The interval between taking Aktiferrin and consuming these foods should be 1-2 hours.

To prevent the appearance of reversible dark deposits on the teeth of patients, syrup and Aktiferrin drops should not be taken undiluted, after eating it is recommended to thoroughly brush your teeth.

When taking Aktiferrin, staining of feces is noted in black, which has no clinical significance.

Control of laboratory indicators

At course use of Actyferrin, systematic monitoring of serum iron and hemoglobin levels is necessary.

Drug Interactions

Antacids, calcium preparations, gastric acidity-reducing agents (including cimetidine, drugs containing carbonates, bicarbonates, phosphates, oxalates), pancreatin, pancreatolase, ethidron, caffeine, reduce the absorption of acti fferrin (the interval between taking these medicines shouldto be 1-2 hours).

When combined, Ascorbic acid increases iron absorption.

Aktiferrin reduces the absorption of fluoroquinolones, penicillamine, tetracyclines (these drugs are recommended to be taken 2 hours before or 2 hours after taking iron preparations).

Actyferrin in high doses reduces renal absorption of zinc preparations (these drugs are recommended to be taken 2 hours after taking iron preparations).

Ethanol (alcohol) increases iron absorption and increases the risk of developing toxic complications.

Analogues of the drug Actyferrin

Structural analogs for the active substance:

• Aktiferrin compositum.

Analogues on the pharmacological group (drugs, stimulators of hematopoiesis):

• Aranesp;
• Argeferr;
• Biofer;
• Venofer;
• Vitamin B12;
• Hemofer;
• Granogen;
• Grazalva;
• The iron fumarate;
• Iron polymaltose;
• CosmoFer;
• Leukogen;
• To the Leichest;
• Maltofer;
• Maltofer Foul;
• Methyluracil;
• Myelastra;
• Mozobail;
• Monofer;
• Neutrostim;
• Neostimium;
• Unstable;
• Panagen;
• Pentoxyl;
• The Revolade;
• Sorbifer Durules;
• Tardiferon;
• Tevagrastim;
• Totem;
• Fenules 100;
• Ferlatum;
• Ferretab;
• Ferrinate;
• Ferrohematogen;
• Ferronal;
• Ferronat;
• Ferroplex;
• Ferrum Lek;
• Filgrastim;
• Fitin;
• Folacin;
• Folic acid;
• Folic acid forte;
• Heferol;
• Ceruloplasmin;
• Cyanocobalamin;
• Epokrin;
• Epomax;
• Eralfon;
• Erythropoietin;
• Erythrostim.

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