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Mexiprim - instructions for use, reviews, analogs and formulations (125 mg tablets, injectable injections) drugs for the treatment of neuroses, neurasthenia and other mental disorders in adults, children and pregnancy. Composition

Mexiprim - instructions for use, reviews, analogs and formulations (125 mg tablets, injectable injections) drugs for the treatment of neuroses, neurasthenia and other mental disorders in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Mexipur. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of medical experts on the use of Mexipriem in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogs of Mexiprim in the presence of existing structural analogues.Use to treat neuroses, neurasthenia and other mental disorders in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

 

Mexipur antioxidant drug. Has a wide range of pharmacological activities: increases the body's resistance to stress, manifests an anxiolytic effect, not accompanied by muscle relaxation; has nootropic properties, prevents and reduces the learning and memorization process disturbances that occur with aging and the effects of various pathogenic factors; has an anticonvulsant effect; exhibits antioxidant and antihypoxic properties; increases concentration and efficiency; alleviates the toxic effects of alcohol.

 

The drug improves the metabolism of brain tissues and their blood supply, improves microcirculation and rheological properties of blood, reduces the aggregation of platelets. Stabilizes the membrane structures of blood cells (erythrocytes and platelets). Has hypolipidemic action, reduces the content of total cholesterol and LDL.

 

The mechanism of action of Mexiprim is due to its antioxidant and membrane-protective action.It inhibits lipid peroxidation, increases the activity of superoxide oxidase, increases the ratio of lipid-protein, reduces the viscosity of the membrane, increases its fluidity. Modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, contributes to the preservation of the structural and functional organization of biomembranes, neurotransmitter transport, and improved synaptic transmission. Mexuprim increases the content of dopamine in the brain. It causes an increase in the compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under conditions of hypoxia with an increase in the content of ATP and cretin phosphate, activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes.

 

Composition

 

Ethyl methylhydroxypyridine succinate + auxiliary substances.

 

Pharmacokinetics

 

After ingestion, the drug is rapidly absorbed from the gastrointestinal tract with a half-absorption period of 0.08-0.1 hours. It is intensively metabolized in the liver to form its glucuron conjugate.The average retention time of the drug in the body is 4.9-5.2 hours. On average, 0.3% of active substance is unchanged in 12 hours with urine and 50% in the form of glucuronic conjugate. The most active substance and its glucuron conjugate are excreted within the first 4 hours after taking the drug. The excretion rates in urine of the active substance and its conjugated metabolite have a significant individual variability.

 

Indications

  • anxiety disorders in neurotic and neurosis-like states;
  • vegetative-vascular dystonia;
  • light cognitive disorders of various genesis (with psycho-organic syndrome and asthenic disorders due to acute and chronic disorders of cerebral circulation, craniocerebral trauma, neuroinfections and intoxications, senile and atrophic processes);
  • memory disorders and intellectual insufficiency in the elderly;
  • the impact of extreme (stressful) factors;
  • abstinence syndrome with alcoholism with a predominance of neurosis-like and vegetative-vascular disorders.

 

Forms of release

 

Tablets coated with 125 mg.

 

Solution for intravenous and intramuscular injection (injections in ampoules for injection).

 

Instructions for use and dosing regimen

 

Pills

 

Mexipurum is administered orally. The therapeutic dose and duration of treatment are determined by the patient's sensitivity to the drug.

 

At the beginning of treatment the drug is prescribed in a dose of 250-500 mg, the average daily dose is 250-500 mg, the maximum daily dose is 800 mg. The daily dose is divided into 2-3 doses during the day.

 

For treatment of anxiety disorders, vegetative-vascular dystonia and cognitive impairment, the drug is used for 2-6 weeks.

 

When cupping an alcohol withdrawal syndrome, the duration of use is 5-7 days.

 

Course therapy Mexiprim is completed gradually, reducing the dose for 2-3 days.

 

Ampoules

 

Mexiprim is administered intramuscularly or intravenously (either by jet or by drop (as a dropper)). To prepare a solution for infusion, the drug should be diluted with an isotonic sodium chloride solution.

 

Doses are selected individually depending on the pathology and severity of the patient's condition. The initial dose is 50-100 mg 1-3 times a day.In the future, it is possible to increase the dose to obtain a therapeutic effect. The maximum daily dose is 800 mg.

 

Jet Miksiprim injected slowly, for 5-7 minutes, drip - at a speed of 40-60 drops / min.

 

In the treatment of acute disorders of cerebral circulation, Mexiprin is used in complex therapy in the first 2-4 days IV drip in a dose of 200-300 mg once a day, then in / m at 100 mg 3 times a day. The duration of treatment is 10-14 days.

 

With discirculatory encephalopathy in the phase of decompensation, Mexiprim should be given intravenously or intravenously in a dose of 100 mg 2-3 times a day for 14 days. Then the drug is given in / m at 100 mg per day for the next 2 weeks. For the course of prophylaxis of discirculatory encephalopathy, the drug is administered in / m at a dose of 100 mg twice a day for 10-14 days.

 

With mild cognitive impairment in elderly patients and with anxiety disorders, the drug is used in / m in a daily dose of 100-300 mg for 14-30 days.

 

With abstinent alcoholic syndrome, Mexiprin is administered at a dose of 100-200 mg IM 2-3 times a day or iv dropwise 1-2 times a day for 5-7 days.

 

In acute intoxication with antipsychotic drugs, the drug is administered IV in a dose of 50-300 mg per day for 7-14 days.

 

Side effect

  • nausea;
  • dry mouth;
  • drowsiness;
  • allergic reactions.

 

Contraindications

  • liver failure;
  • kidney failure;
  • pregnancy;
  • the period of breastfeeding;
  • childhood;
  • hypersensitivity to the drug.

 

Application in pregnancy and lactation

 

Contraindicated use of the drug during pregnancy and lactation.

 

Use in children

 

Adequate and strictly controlled clinical studies of the safety of the use of the drug Meximore in children have not been conducted, therefore, one should not prescribe a drug of this category of patients.

 

special instructions

 

The drug is released by prescription.

 

Overdose may develop drowsiness.

 

Impact on the ability to drive vehicles and manage mechanisms

 

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of the psychomotor reaction.

 

Drug Interactions

 

Mexipur is compatible with psychotropic drugs.

 

When combined, increases the effect of anxiolytics (benzodiazepine derivatives), antiparkinsonics and carbamazepine.

 

Mexiprim reduces the toxic effect of ethanol (alcohol).

 

Analogues of Mexicem drug

 

Structural analogs for the active substance:

  • 2-ethyl-6-methyl-3-hydroxypyridine succinate;
  • 3-hydroxy-6-methyl-2-ethylpyridine succinate;
  • Medomexi;
  • Mexidant;
  • Mexidol;
  • Mexidol injection 5%;
  • Mexicor;
  • Mexipridol;
  • Mexicin;
  • Metostabil;
  • Neurox;
  • Cerekard;
  • Ethyl methylhydroxypyridine succinate.

 

Analogues for the pharmacological group (antihypoxants and antioxidants):

  • Actovegin;
  • Angiosyl retard;
  • Antisthenes;
  • Valeocorus Q10;
  • Vitanam;
  • Hypoxen;
  • Histochrome;
  • Glathion;
  • Depenorm MB;
  • Dimephosphone;
  • Cardiocipine;
  • Carnitine;
  • Carniffite;
  • Confusamine;
  • Kudevita;
  • Qudesan;
  • Kudesan for children;
  • Kudesan Forte;
  • Laproth;
  • Levocarnitine;
  • Limonar;
  • Mexidol;
  • Metagard;
  • Methyl ethylpyridinol;
  • Mitomin;
  • Sodium oxybutyrate;
  • Oxyl;
  • Oliphen;
  • Predizin;
  • Preductal;
  • Preductal MB;
  • Precardard;
  • Proxipin;
  • Romekor;
  • Solcoseryl;
  • Tiogamma;
  • Tiotriazolin;
  • Trekrezan;
  • Tridoukard;
  • Trimectal;
  • Trimetazidine;
  • Phenosanic acid;
  • Cytochrome C;
  • Emoxipine;
  • Energet;
  • Ethylthiobenzimidazole hydrobromide;
  • Ethoxydol;
  • Yantavit.

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