Pimafucin - instructions for use, reviews, analogs and formulations (100 mg tablets, vaginal suppositories, cream or ointment 2%) drugs for the treatment of candidiasis (thrush) in adults, children and pregnancy

In this article, you can read the instructions for using the drug Pimafucine. There are reviews of visitors to the site - consumers of this medication, as well as opinions of specialists on the use of Pimafucine in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Pimafucin in the presence of existing structural analogues. Use for the treatment of candidiasis (thrush, vaginitis, as well as fungal diseases of the skin and mucous membranes in adults, children, as well as during pregnancy and lactation.

Pimafucine - antifungal polyene antibiotic from the group of macrolides, which has a wide spectrum of action. It has a fungicidal effect. Natamycin (the active substance of the drug Pimafucin) binds the sterols of the cell membrane of the fungal cell, disrupting its integrity and function, which leads to cell death.

Most pathogenic yeast fungi are sensitive to natamycin, especially Candida albicans.

Less sensitive to natamycin is dermatophytes.

Resistance to Pimafucine in clinical practice is not noted.

Pharmacokinetics

When administered orally, natamycin is not practically absorbed from the digestive tract. When applied to the skin and mucous membranes, practically does not undergo systemic absorption, so it does not have a systemic effect.

Indications

For tablets:

• treatment and prevention of non-invasive candidiasis of the intestine (including after taking antibiotics, cytostatics, corticosteroids).

For cream or ointment:

• fungal diseases of the skin and mucous membranes caused by susceptible pathogens (including vaginitis, vulvitis, vulvovaginitis, balanoposthitis caused by fungi of the genus Candida, candidiasis of skin and nails, external otitis, or primarily caused by fungi,or complicated by candidiasis; dermatomycosis).

For vaginal suppositories:

• vaginitis, vulvitis, vulvovaginitis caused by fungi of the genus Candida.

Forms of release

Tablets coated with enteric coating 100 mg.

Candles vaginal 100 mg.

Cream or ointment for external use 2%.

Instructions for use and reception scheme

With candidiasis of the intestine, adults are prescribed 100 mg (1 tablet) 4 times a day for an average of 1 week. Children are prescribed 100 mg (1 tablet) 2 times a day.

With dermatomycosis (including candidiasis of the skin, diaper rash in children), the cream is applied to the affected surface of the skin one or more (up to 4) times a day.

With mycosis of the external auditory canal, the affected surface is cream coated once or several times (up to 4 times) per day. Before using the drug, the ear is cleaned. After applying the drug in the ear canal, put a tampon made of natural material (cotton, wool).

With vaginitis, vulvitis, vulvovaginitis, one vaginal candle is prescribed for 3-6 days. The suppository is inserted into the vagina in the supine position, as deep as possible, once a day at night. With persistent flow of vaginitis caused by Candida albicans,additionally prescribed Pimafucin in the form of tablets for oral administration (1 tablet 4 times a day for 10-20 days) to sanitize the focus of candidiasis infection in the intestine. For the treatment of candidal lesions of the partner's genitals use Pimafucin in the form of a cream.

With vulvitis, vulvovaginitis, balanoposthitis, the cream is applied to the affected areas of the skin once or several times a day.

The duration of the course of treatment is set individually. After the disappearance of the symptoms of the disease is recommended to continue treatment a few more days.

Side effect

• nausea;
• Diarrhea (arising during the first days of taking the drug in the form of tablets and passing alone during the treatment);
• slight irritation;
• burning sensation (with the use of cream, suppositories of vaginal).

Contraindications

• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Possible use of Pimafucin during pregnancy and lactation.

Data on adverse effects on the fetus are absent.

special instructions

Candles vaginal under the influence of body temperature quickly dissolve, forming a foamy mass, which contributes to a uniform distribution of the active substance.

In the case of a chronic or recurrent infection, local treatment can be supplemented with the administration of Pimafucine in the form of tablets and cream for external use.

Cetyl alcohol, which is a part of vaginal suppositories, can cause a slight burning sensation with increased sensitivity to this component.

During the menstrual period, suppositories are interrupted.

During the use of suppositories, there is no need to exclude sexual contact. However, it is recommended to conduct a survey of sexual partners and, in case of detection of candidal defeat, to treat Pimafucin. Also, during the period of treatment, barrier means of contraception should be used.

Use in Pediatrics

Pimafucin in a medicinal form cream for external use can be administered to newborns.

Impact on the ability to drive vehicles and manage mechanisms

Pimafucin does not affect the ability to drive vehicles and control mechanisms.

Drug Interactions

Drug interaction of the drug Pimafucin is not described.

Analogues of the drug Pimafucin

Structural analogs for the active substance:

• Natamycin;
• Primafungin.

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