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Thiocetam - instructions for use, analogs, reviews and release forms (tablets 200 + 50 mg, Forte 400 + 100 mg, injections in ampoules for injection in solution) for the treatment of stroke and encephalopathy in adults, children and pregnancy. Composition

Thiocetam - instructions for use, analogs, reviews and release forms (tablets 200 + 50 mg, Forte 400 + 100 mg, injections in ampoules for injection in solution) for the treatment of stroke and encephalopathy in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Thiocetam. There are reviews of visitors to the site - consumers of this medicine, as well as opinions of doctors of specialists on the use of Thiocetam in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Thiocetam in the presence of existing structural analogues. Use for the treatment of stroke, encephalopathy and other ischemic disorders in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

 

Thiocetam - belongs to the group of cerebroactive agents, shows nootropic anti-ischemic and antioxidant properties. The pharmacological effect of the drug is due to the mutual potentiating action of thiotriazoline and piracetam.

 

Piracetam is a cyclic, derivative of GABA, a nootropic agent; works directly on the brain, improving functions such as learning, memory, attention and consciousness without exerting sedative or psychostimulating effects. At the neuronal level, Piracetam facilitates various types of synaptic transmission, with a predominant effect on the density and activity of postsynaptic receptors. The hemorheological effects of pyracetam are related to its effect on erythrocytes, platelets and the vessel wall.

 

Tiotriazolin reacts with the active forms of oxygen and lipid radicals due to the pronounced reducing properties of the thiol group and prevents the formation of reactive oxygen species by reactivation of antiradical enzymes: superoxide dismutase, catalase and glutathione peroxidase.

 

Thiocetam improves the integrative and cognitive activity of the brain, facilitates the learning process, eliminates amnesia,increases the indicators of short-term and long-term memory.

 

Composition

 

Piracetam + Tiotriazolin + auxiliary substances.

 

Indications

  • chronic ischemia of the brain;
  • the recovery period of ischemic stroke (including in patients with non-cognitive impairment);
  • diabetic encephalopathy.

 

Forms of release

 

Tablets of 200 mg + 50 mg (sometimes mistakenly called capsules).

 

Forte tablets 400 mg + 100 mg.

 

Solution for intramuscular and intravenous administration (injections in ampoules for injection)

 

Instructions for use and dosing regimen

 

Pills

 

Inside, 30 minutes before eating.

 

For chronic disorders of cerebral circulation and during the recovery period after an ischemic stroke 2 tablets 3 times a day for 25-30 days. The course of treatment can be extended to 3-4 months.

 

To treat diabetic encephalopathy, 2 tablets are prescribed 3 times a day for 45 days.

 

The last dose is taken no later than 17 hours (to prevent sleep disturbance).

 

Forte Tablets

 

With transient and chronic disturbances of cerebral circulation and during the rehabilitation period after ischemic and hemorrhagic stroke, 1 tablet 3 times a day for 25-30 days.

 

Tablets Thiocetam Forte appoint 30 minutes before meals.

 

The course of treatment is from 2-3 weeks to 3-4 months.

 

For the treatment of diabetic encephalopathy, 1 tablet is prescribed 3 times a day for 45 days.

 

Ampoules

 

The drug is administered intravenously, intramuscularly only if it is not possible to take it inside.

 

For chronic disorders of cerebral circulation and during the recovery period after ischemic stroke, 20-30 ml of the drug, previously diluted in 100-150 ml of 0.9% sodium chloride solution, are prescribed and injected / dripped 1 time per day. The course of treatment is 2 weeks, then go to the tablet form.

 

With diabetic encephalopathy appoint 5 ml IM once a day for 10 days with the subsequent appointment of a tablet form.

 

Side effect

  • motor disinhibition;
  • irritability;
  • drowsiness;
  • depression;
  • asthenia;
  • headache;
  • dizziness;
  • noise in ears;
  • insomnia;
  • mental agitation;
  • disturbance of balance;
  • ataxia;
  • exacerbation of epilepsy;
  • anxiety;
  • hallucinations;
  • confusion of consciousness;
  • nausea, vomiting;
  • diarrhea;
  • pain in the abdomen (including gastralgia) and bloating;
  • dry mouth;
  • tachycardia;
  • increased blood pressure;
  • pain in the heart;
  • arrhythmias;
  • elderly patients may experience an exacerbation of coronary insufficiency;
  • hypersensitivity;
  • anaphylactic reactions, including dermatitis, pruritus, hives and angioedema;
  • fever;
  • dyspnea;
  • attacks of suffocation;
  • increase in body weight;
  • Vertigo.

 

Contraindications

  • hypersensitivity to pyracetam or thiotriazoline, as well as to other components of the drug;
  • Huntington's chorea;
  • acute violation of cerebral circulation (hemorrhagic stroke);
  • severe chronic renal failure (creatinine clearance less than 20 ml / min);
  • psychomotor agitation at the time of prescribing;
  • childhood;
  • pregnancy and lactation;
  • hereditary lactose intolerance, lactase deficiency;
  • deficiency of sugar / isomaltase, intolerance to fructose;
  • glucose-galactose malabsorption.

 

Application in pregnancy and lactation

 

The experience of using the drug Thiocetam during pregnancy or lactation is absent, so the drug should not be assigned to this category of women.

 

Use in children

 

Experience in the use of the drug for the treatment of children there, so the drug is contraindicated for the treatment of children and adolescents under the age of 18 years.

 

Application in elderly patients

 

With caution should apply the drug to elderly people with cardiovascular pathology due to the fact that this group of patients have more frequent adverse reactions.

 

With prolonged therapy in elderly patients, regular monitoring of kidney function is recommended, if necessary, dose adjustment is performed depending on the creatinine clearance.

 

special instructions

 

With caution, the drug is prescribed to patients with chronic renal failure (creatinine clearance 20-80 ml / min). Thiocetam affects the aggregation of platelets, so it must be used with caution in patients with

violation of hemostasis, with surgical interventions, severe bleeding.

 

Influence on ability of driving of vehicles and on management of cars and mechanisms

 

During the treatment period it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions (driving a car, etc.).

 

Drug Interactions

 

Thiocetam can not be simultaneously administered with drugs that have an acidic pH. Due to the presence of piracetam, the effect of antidepressants and antianginal drugs is enhanced. With concomitant administration with thyroid hormones, confusion, irritability and sleep disturbance are possible.

 

Pyracetam does not inhibit cytochrome P450 isoenzymes. Metabolic interaction with other drugs is unlikely.

 

Joint intake with alcohol did not affect the level of piracetam concentration in the serum concentration of ethanol (alcohol) in the blood serum, did not change when taking 1.6 g of piracetam.

 

Analogues of the drug Thiocetam

 

The thiocetam has no structural analogs for the active substance. Nootropics are unique in the combination of active ingredients in the formulation.

 

Analogues for the pharmacological group (nootropics):

  • Amylonosar;
  • Aminalon;
  • Vinpotropil;
  • Gamalon;
  • Ginkyo;
  • Gliatilin;
  • Glycine;
  • Gopantam;
  • Idebenon;
  • Combbitropyl;
  • Cortexin;
  • Cortexin for children;
  • Lucetsam;
  • Mexiprim;
  • Memotropized;
  • Minisem;
  • Neuromet;
  • Hoenopt;
  • Nootropil;
  • Noophen;
  • Noocetam;
  • Omaron;
  • Pantogam;
  • Pantokaltsin;
  • Pikamilon;
  • Piraben;
  • Piracesine;
  • Piracetam;
  • Pyriditol;
  • Semax;
  • Stamine;
  • Tenoten;
  • Fezam;
  • Fenibut;
  • Phenotropil;
  • Choline alphoscerate;
  • Holilitil;
  • Ceraxon;
  • Cerebrosolate;
  • Cerebrolysin;
  • Cerepro;
  • Energol;
  • Encephabol;
  • The escotrope.

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Reviews (8):
Guests
Irina
With intravenous administration of the drug, I feel a burning sensation throughout the body, then it passes. Could this be an indicator that it does not suit me?
Administrators
admin
Irina, Perhaps this is your individual reaction to intravenous infusions of any drug (not necessarily Thiocetam). If there are no other symptoms, I would try to continue the treatment, although if the burning is unbearable, then you need to look at the diagnosis and change either the dosage or the drug itself for a similar one.
Guests
Natalia.
I received injections and pills, but the doctor did not explain how to take the medicine. First, injections, and then tablets or you can simultaneously?
Administrators
admin
Natalia., In the standard schemes, first a course of injections, and after the pill, capsule, powder. Most likely, according to a similar scheme, Thyocetam was appointed to you.
Guests
Irina
Can I use tablets with thiocetam with L-thyroxine?
Administrators
admin
Irina, Can. According to the instruction of negative side effects with the joint use of Thiocetam and L-thyroxine should not be. Initially, thyroxine is taken and only 30 minutes later you can take Thiocetam and other medications (if the morning time for taking medications is prescribed).
Visitors
Sara
The neurologist has appointed or nominated Etoksidol 2,0 v / m № 10 and Thiocetam 5,0 v / m № 10. These two medicines need to be put in parallel or consistently? I do not understand. I shall be grateful to you for the answer.
Administrators
admin
Sara, Can be consecutively, can be parallel. If you enter together, then stab in different buttocks and in different syringes. Both injection solutions in the same syringe are not mixed.

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