Miuropriston - instructions for use, analogs, reviews and release forms (200 mg tablets) medications for abortion early in pregnancy or medical abortion, stimulation of labor in women. Composition and administration of the drug

In this article, you can read the instructions for using the drug Miropristone. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Miropristone in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Mirabyston in the presence of existing structural analogues. Use for abortion early in pregnancy or medical abortion, stimulation of labor in women. Composition and scheme of drug administration.

Miropristone - is a synthetic steroidal anti-gestagen. Blocks the action of Progesterone at the receptor level. Gestagenic activity does not possess, antagonism with glucocorticosteroids (GCS) is noted (due to competition at the level of communication with receptors).

Increases the contractile ability of the myometrium, stimulating the release of interleukin-8 in choroid-epidural cells and increasing the sensitivity of the myometrium to prostaglandins. As a result of the action of the drug desquamation of the decidual membrane occurs and excretion of the fetal egg.

Composition

Mifepristone + excipients.

Pharmacokinetics

After a single oral intake in a dose of 600 mg. Absolute bioavailability is 69%. Binding to plasma proteins is 98% (with albumin and acid alpha-1 glycoprotein). Excretion is carried out in two phases: first slow release of the drug for 12-72 h (the concentration of Mifepristone in the blood plasma is reduced by 2 times), then the phase of rapid elimination of the drug.

Indications

• interruption of uterine pregnancy in early periods (up to 42 days amenorrhea) in combination with misoprostol (peace);
• preparation and induction of labor (admission before childbirth).

Forms of release

Tablets 200 mg.

Instructions for use and dosing regimen

The drug should be used only in medical institutions that have appropriately trained medical personnel and the necessary equipment.

For drug-induced abortion in early terms, the drug is prescribed in a dose of 600 mg (3 tablets) once. In the presence of a doctor, the drug is taken orally within 1-1.5 hours after eating (light breakfast), drinking 100 ml of boiled water. After 36-48 hours after taking Miropristone, the patient must go to a medical institution for taking Misoprostol (millyut) at a dose of 400 micrograms. After taking misoprostol, you need a dynamic observation of the doctor within 2 hours. After 10-14 days, a clinical examination and ultrasound are repeated, if necessary, determine the level of chorionic gonadotropin to confirm abortion.

In the absence of the effect of the drug on day 14 (incomplete abortion or continuing pregnancy), vacuum aspiration is carried out followed by a histological examination of the aspirate.

For the preparation and induction of labor, the drug is prescribed in a dose of 200 mg (1 tablet) in the presence of a doctor.After 24 hours, re-administer the drug at a dose of 200 mg. After 48-72 hours, the condition of the birth canals is evaluated and, if necessary, prostaglandins or oxytocin are administered.

Side effect

• a feeling of discomfort in the lower abdomen;
• general weakness;
• headache;
• nausea, vomiting;
• dizziness;
• hyperthermia;
• hives;
• bloody discharge from the genital tract;
• pain in the lower abdomen;
• exacerbation of inflammatory processes of the uterus and appendages.

Contraindications

• adrenal insufficiency;
• long-term use of GCS;
• acute or chronic renal failure;
• acute or chronic hepatic impairment;
• porphyria;
• uterine fibroids (for this dosage form);
• anemia (hemoglobin level less than 100 g / l);
• violations of hemostasis (including previous therapy with anticoagulants);
• acute inflammatory diseases of female genital organs;
• presence of severe extragenital pathology;
• Smoking women older than 35 years (without prior consultation of the therapist);
• the presence in the anamnesis of hypersensitivity to mifepristone.

For drug abortion:

• suspicion of ectopic pregnancy;
• pregnancy, not confirmed by clinical studies;
• pregnancy for more than 42 days amenorrhea;
• Pregnancy caused by the use of intrauterine contraception or after the abolition of hormonal contraception.

For the preparation and induction of labor:

• severe gestosis;
• preeclampsia;
• eclampsia;
• premature or premature pregnancy;
• discrepancy between the size of the pelvis of the mother and the head of the fetus;
• abnormal position of the fetus;
• bloody discharge during pregnancy from the genital tract, unspecified etiology;
• premature discharge of amniotic fluid;
• severe forms of hemolytic disease of the fetus.

Application in pregnancy and lactation

The drug is used to interrupt uterine pregnancy at an early age (up to 42 days amenorrhea) in combination with misoprostol, as well as for the preparation and induction of labor.

When prescribing the drug should stop breastfeeding for 3 days after taking Miropristone in case of medical abortion.

The use of Miropristone to prepare the cervix for delivery does not affect subsequent lactation.

Application in elderly patients

In elderly patients is not applied.

special instructions

Patients who use Miuropriston for early termination of pregnancy should be informed that if there is no effect on the 10-14 day use of the drug (incomplete abortion or continuing pregnancy), pregnancy should necessarily be discontinued in another way because of the risk of congenital malformations in the fetus.

The use of the drug requires the prevention of rhesus-alloimmunization and other common activities associated with abortion.

With caution should prescribe the drug for chronic obstructive pulmonary diseases, bronchial asthma, arterial hypertension, heart rhythm disorders, heart failure.

The drug can be delivered only to medical obstetric and gynecological institutions related to the public health system, as well as to municipal and private property agencies that have licenses for this type of activity.

Drug Interactions

With the simultaneous application of Miropristone and glucocorticosteroids (GCS), it is necessary to increase the dose of the latter.

It is necessary to avoid simultaneous administration of Miropristone with non-steroidal anti-inflammatory drugs (NSAIDs).

Analogues of Miuropriston

Structural analogs for the active substance:

• Agesta;
• Ginepristone;
• Gynestrel;
• Wife;
• Mifegin;
• Mifeprex;
• Mifepristone;
• Pencrofton.

Similar medicines:

Other medicines: