Metromikon Neo - instructions for use, reviews, analogues and forms of release (candles vaginal № 7 and 14) drugs for the treatment of candidiasis or thrush, vaginitis in women, including during pregnancy or menstruation. Composition

In this article, you can read the instructions for using the drug Metronikon Neo. There are reviews of visitors to the site - consumers of this medication, as well as the opinions of the specialists in the use of Metronikon Neo in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Neo Metronikon with available structural analogues. Use to treat candidiasis or thrush, vaginitis in women, including during pregnancy or menstruation.Composition of the preparation.

Metronikon Neo - is a drug with a bactericidal type of action, showing tropicity (the ability of interaction) to deoxyribonucleic acid.

The mechanism of action is the biochemical reduction of the 5-nitro group of Metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole reacts with the deoxyribonucleic acid of a cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.

It is active against the protozoans: Trichomonas vaginalis (Trichomonas), Entamoeba histolytica, and obligate anaerobic bacteria: Gram-negative bacteria - Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella spp; (Prevotella bivia, Prevotella buccae, Prevotella disiens), gram-positive - Clostridium spp., Eubacterium spp., Peptococcus spp. (peptococcus), Peptostreptococcus spp :, Mobiluncus spp. and facultative anaerobe - Gardnerella vaginalis (Gardnerella).

Metronidazole (the active ingredient of Metronikon Neo) is insensitive to aerobic microorganisms, but in the presence of mixed flora (aerobes, and anaerobes), metronidazole acts synergistically with antibiotics effective against conventional aerobes.

Miconazole is an antifungal agent, azole derivative. When intravaginal application is active mainly in relation to Candida albicans (candida).The fungicidal and fungistatic effect of miconazole is due to inhibition of the biosynthesis of the ergosterol membrane and plasma membranes of fungi, changes in the lipid composition and permeability of the cell wall, causing death of the fungal cell.

Composition

Metronidazole + miconazole + excipients.

Pharmacokinetics

Compared with oral administration, the bioavailability of metronidazole for intravaginal administration is 20%. Metronidazole is metabolized in the liver. Hydroxyl metabolites are active.

The half-life of metronidazole is 6 to 11 hours. About 20% of the dose is excreted unchanged in the urine.

With intravaginal administration, miconazole is absorbed only slightly and is not detected in the plasma.

Indications

Vaginal infections:

• vaginal candidiasis;
• trichomonas vaginitis and vulvovaginitis, bacterial vaginosis;
• mixed vaginal infection.

Forms of release

Candles vaginal in a package of 7 or 14 pieces.

Instructions for use and how to use them

Intravaginal.

Acute vaginitis, bacterial vaginosis: 1 suppository in the morning and at night for 7 consecutive days.

Chronic vaginitis: 1 candle once a day, just before bedtime, for 14 consecutive days.

Often recurrent vaginitis or in the absence of positive clinical dynamics when treated by other methods: 1 suppository in the morning and at night for 14 days.

Preliminarily releasing the suppository from the contour pack using scissors (cut the film along the contour of the suppository), insert it deep into the vagina.

Side effect

• burning, itching, irritation of the mucous membrane of the vagina and increased swelling;
• pain or cramps in the abdomen;
• metallic taste;
• dry mouth;
• constipation, diarrhea;
• loss of appetite;
• nausea, vomiting;
• headache;
• motor disorders (ataxia);
• dizziness;
• psychoemotional disorders;
• convulsions;
• leukopenia;
• skin rashes, including hives.

Contraindications

• hypersensitivity to the components of the drug or other derivative of nitroimidazole;
• 1 trimester of pregnancy;
• lactation period;
• children's age till 18 years;
• with virgins.

Application in pregnancy and lactation

The purpose of the drug is contraindicated in the first trimester of pregnancy. Application in the 2nd and 3rd trimesters of pregnancy is possible only if the potential benefit to the mother exceeds the possible risk to the fetus.

If it is necessary to prescribe the drug during lactation, breastfeeding should be discontinued, as metronidazole penetrates into breast milk. Breastfeeding can be resumed 24-48 hours after the end of treatment.

Use in children

Contraindicated in children and adolescents under the age of 18 years.

special instructions

When using the drug should refrain from sexual intercourse. In order to avoid re-infection, simultaneous treatment of the sexual partner is necessary. In the case of trichomonas vaginitis, simultaneous treatment of the sexual partner with metronidazole is advisable for oral administration.

During treatment and at least 24-48 hours after the end of treatment, ethanol should be avoided (ethanol intolerance is possible).

It is not recommended simultaneous use of the drug with contraceptive diaphragms and condoms from rubber or latex (possibly interaction with price suppositories).

If the vagina is strongly irritated, the drug should be discontinued.

Suppositories Metromicon Neo should be used only intravaginally, they can not be swallowed or used in any other way.

In the case of using the drug in conjunction with metronidazole for oral administration, especially in the second course, control of the picture of peripheral blood (danger of leukopenia) is necessary.

During the menstruation, the course of treatment should be interrupted and resumed after.

Impact on the ability to drive vehicles and manage potentially dangerous mechanisms

It is advisable to be cautious, since a possible, negative impact on the ability to drive a motor vehicle and manage complex machinery can not be ruled out. When there are side effects from the central nervous system, one should refrain from managing motor vehicles and working with potentially dangerous mechanisms.

Drug Interactions

In connection with the entry of metronidazole into the systemic blood stream, the following reactions of interaction can be noted while simultaneously applying with certain substances:

Oral anticoagulants: the effect of indirect anticoagulants is enhanced.

Disulfiram: there may be abnormalities from the CNS (mental reactions); not, should appoint metronidazole to patients who have been taking Disulfiram for the past 2 weeks.

Phenytoin: the concentration of phenytoin in the blood increases, and the concentration of metronidazole in the blood decreases.

Lithium preparations: there may be an increase in their toxicity.

Phenobarbital: the concentration of metronidazole in the blood decreases.

Cimetidine: may increase the concentration of metronidazole in the blood.

Astemizol and terfenadine: Metronikon Neo inhibits the metabolism of these drugs and increases the concentration in the blood plasma.

Ethanol: the interaction of metronidazole with ethanol (alcohol) causes disulfiram-like reactions.

Analogues of the drug Metronikon Neo

Structural analogs for the active substance:

• Clion D 100;
• Neo Penotran;
• Neo Piotrand Forte.

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