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Singlon - instructions for use, analogs, reviews and release forms (10 mg tablets, chewing 4 mg and 5 mg) medications for the treatment and prevention of bronchial asthma, including aspirin in adults, children and pregnancy. Composition

Singlon - instructions for use, analogs, reviews and release forms (10 mg tablets, chewing 4 mg and 5 mg) medications for the treatment and prevention of bronchial asthma, including aspirin in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Singlon. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Singlon in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Singlon in the presence of existing structural analogues. Use for the treatment and prevention of bronchial asthma,including Aspirin and bronchospasm in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

 

Singlon - a specific antagonist of leukotriene receptors for oral administration. Montelukast (active ingredient of the preparation Singlon) has the ability to inhibit bronchospasm due to the inhalation of LTD4 in very low doses (5 mg). Bronchodilation is observed within 2 hours after ingestion. The effect of bronchodilation, caused by beta-adrenomimetic, is supplemented by the action of montelukast. Singlon inhibits the early and late phases of bronchoconstriction caused by the introduction of antigen. Montelukast reduces the number of eosinophils in the peripheral blood, in the respiratory tract (in sputum) of adult patients and children and improves control over the course of bronchial asthma.

 

Montelukast significantly improves the morning FEV (volume of forced exhalation) for 1 second, MOSV (maximum volumetric expiratory flow rate) and significantly reduces the need for beta-adrenomimetics.

 

Singlon enhances the effect of inhaled glucocorticosteroids. Montelukast significantly weakens bronchospasm, which occurs against the background of physical activity.In patients with bronchial asthma, sensitive to Acetylsalicylic acid and taking concomitant inhalation and / or oral glucocorticosteroids, treatment with montelukast leads to a significant improvement in the control of symptoms of bronchial asthma.

 

Composition

 

Montelukast sodium + excipients.

 

Pharmacokinetics

 

Singlon is quickly absorbed after ingestion. On average, the bioavailability after oral administration is 64%. Eating does not affect bioavailability. Montelukast is more than 99% bound to plasma proteins. The drug penetrates poorly through the blood-brain barrier. Concentrations of montelukast 24 hours after application of the drug were minimal in all tissues of the body. Exposed to intensive metabolism. When therapeutic doses are used, the concentration of metabolites of montelukast in plasma in equilibrium in adults and children is not determined. The contribution of metabolites to the therapeutic effect of montelukast is minimal. After taking montelukast, 86% of the drug is taken out through the intestine and less than 0.2% by the kidneys. The drug and its metabolites are excreted mainly with bile.

 

For the elderly, patients with mild or moderate hepatic insufficiency, dose adjustment is not required.

 

Indications

  • long-term treatment and prevention of bronchial asthma (including the prevention of day and night symptoms of the disease);
  • treatment of "aspirin" asthma and prevention of bronchospasm of physical effort.

 

Forms of release

 

The tablets covered with a cover of 10 mg.

 

Tablets chewing 4 mg and 5 mg (children 2-5 years (tablets chewing 4 mg) and children 6-14 years (tablets chewing 5 mg)).

 

Instructions for use and dosing regimen

 

Tablets 10 mg

 

Inside.

 

Adults and adolescents aged 15 years and over to treat bronchial asthma take 1 tablet of the drug Singlon 10 mg daily in the evening, regardless of food intake.

 

General recommendations

 

The therapeutic effect of the drug Singlon on the symptoms associated with bronchial asthma, manifests itself within one day. The patient is recommended to continue taking the drug Singlon both during periods of controlled course of bronchial asthma and during periods of worsening of the course of the disease.

 

The drug Singlon should not be taken together with other drugs containing the same active substance - Montelukast.

 

In elderly patients with mild or moderate renal insufficiency, hepatic insufficiency does not require correction of the dose. Data for patients with severe hepatic insufficiency are absent.

 

The dose of the drug is the same for both female and male patients.

 

The drug Singlon can be included in existing regimens for the treatment of bronchial asthma.

 

Inhaled glucocorticosteroids: Synngon is prescribed for the treatment of bronchial asthma as an additional therapy for patients in whom inhaled glucocorticosteroids and short-acting beta-adrenomimetics, if necessary, do not provide the necessary clinical control of the disease. Montelukast should not replace inhaled glucocorticosteroids.

 

For children aged 6 to 14 years, 5 mg of chewable tablets are used.

 

Tablets chewing for children

 

For children aged 2-5 years, the preparation Singlon is prescribed 1 tablet chewing 4 mg daily in the evening.

 

For children aged 6-14 years, the preparation Singlon is prescribed 1 tablet of chewing 5 mg daily in the evening.

 

The drug Singlon should be taken 1 hour before or 2 hours after eating. Dose adjustments within these age groups are not required.

 

The safety and efficacy of chewable tablets of 4 mg for children under 2 years of age have not been established.

 

General recommendations

 

The therapeutic effect of the drug Singlon develops within one day after admission. The patient should continue taking the drug Singlon both during periods of controlled course of bronchial asthma, and during periods of worsening of the course of the disease.

 

In patients with renal insufficiency, mild or moderate degree of hepatic insufficiency, dose adjustment is not required. Data for patients with severe hepatic impairment are not available.

 

The dose of the drug does not depend on the sex of the patient.

 

Therapy with the drug Singlon in combination with other drugs for the treatment of bronchial asthma

 

If the drug Singlon is appointed against the background of ingestion of glucocorticosteroids (GCS), then you should not suddenly replace inhaled glucocorticosteroids with the drug Singlon.

 

Side effect

  • increased tendency to bleeding;
  • hypersensitivity reactions, including anaphylaxis;
  • eosinophilic liver infiltrates;
  • sleep disturbances, including nightmares, hallucinations, insomnia;
  • irritability;
  • anxiety;
  • Excitement, including aggressive behavior;
  • tremor;
  • depression;
  • suicidal thoughts and suicidal behavior (suicidal);
  • headache;
  • dizziness;
  • drowsiness;
  • paresthesia / hypoesthesia;
  • convulsive seizures;
  • cardiopalmus;
  • stomach ache;
  • diarrhea;
  • dry mouth;
  • dyspepsia;
  • nausea, vomiting;
  • increased activity of transaminases in blood serum (alanine aminotransferase, aspartate aminotransferase);
  • cholestatic hepatitis;
  • angioedema;
  • the appearance of ecchymoses;
  • hives;
  • itching;
  • rash;
  • nodular erythema;
  • arthralgia;
  • Myalgia, including muscle spasms;
  • thirst;
  • asthenia / increased fatigue;
  • discomfort;
  • edema.

 

Contraindications

  • hypersensitivity to the active substance or to any of the excipients;
  • children under 15 years (for tablets 10 mg);
  • children under 2 years of age (for chewing tablets 4 mg);
  • children under 6 years of age (for 5 mg chewing tablets);
  • lactose intolerance, lactase deficiency, glucose-galactose malabsorption.

 

With caution: pregnancy and lactation.

 

Application in pregnancy and lactation

 

The drug Singlon can be used during pregnancy and during breastfeeding, if the expected benefit for the mother exceeds the potential risk to the fetus and the baby.

 

Use in children

 

Contraindicated in children and adolescents under the age of 15 years.

 

For children aged 6 to 14 years, 5 mg of chewable tablets are used.

 

For children aged 2 to 5 years, chewable tablets of 4 mg are used.

 

Application in elderly patients

 

In elderly patients with mild or moderate renal insufficiency, dose adjustment is not required.

 

special instructions

 

The drug Singlon should not replace inhaled or oral glucocorticosteroids.

 

There is no data suggesting the possibility of reducing the dose of oral glucocorticosteroids with the concomitant use of the drug Singlon.

 

In rare cases, systemic eosinophilia, sometimes accompanied by clinical manifestations of vasculitis and Chang-Strauss syndrome, may occur in patients taking medications for the treatment of bronchial asthma, including the Singlon drug; this condition is usually treated with systemic glucocorticosteroids.Such cases are usually, but not always, associated with a decrease in dose or with the elimination of oral glucocorticosteroids. We can neither exclude nor confirm the possibility that the administration of leukotriene receptor antagonists may be associated with the onset of the Chang-Strauss syndrome. Doctors should be aware of the possibility of patients developing eosinophilia, vasculitic rash, an increase in pulmonary symptoms, complications from the heart and / or neuropathy. Patients who have the above symptoms should undergo a second examination, and their treatment regimen should be reviewed.

 

Receiving the drug Singlon does not affect the intake of acetylsalicylic acid and other non-steroidal anti-inflammatory drugs in patients with bronchial asthma with increased sensitivity to acetylsalicylic acid.

 

The drug contains lactose, so it should not be taken to patients with such rare hereditary diseases as lactose intolerance, lactase deficiency, glucose-galactose malabsorption.

 

Effect of the drug on the ability to drive vehicles and mechanisms

 

It is assumed that the drug Singlon does not affect the ability to drive or other mechanisms. However, in very rare cases, patients were drowsy.

 

Drug Interactions

 

The drug Singlon can be administered in conjunction with other drugs traditionally prescribed for the prevention and long-term treatment of bronchial asthma. The drug at recommended doses had no clinically significant effect on the pharmacokinetics of the following drugs: theophylline, prednisone, prednisolone, oral contraceptives (ethinylestradiol / norethisterone 35/1), terfenadine, Digoxin and warfarin.

 

AUC montelukast in plasma was reduced by approximately 40% in patients who took montelukast and phenobarbital. Since CYP3A4 is involved in the metabolism of montelukast, caution should be exercised, especially in children, when using montelukast with CYP3A4 inducers such as phenytoin, Phenobarbital and rifampicin.

 

Studies have shown that montelukast is a potent inhibitor of CYP2C8. However, the results of a study of the clinical interaction of montelukast and rosiglitazone (an example of marker substrates for drugs,the main metabolism of which is carried out by the enzyme CYP2C8) did not reveal the inhibitory effect of montelukast on CYP2C8. Therefore, it is expected that montelukast will not significantly change the conversions of drugs that are metabolized with the participation of this enzyme (for example, paclitaxel, rosiglitazone and repaglinide). When taking high doses of montelukast (at a 20- and 60-fold excess of the recommended dose for adults), a decrease in the concentration of theophylline in the plasma is observed. This effect is not observed when taking the drug at recommended doses - 10 mg per day.

 

Analogues of the drug Singlon

 

Structural analogs for the active substance:

  • Monax;
  • Moncast;
  • Montelar;
  • Montelast;
  • Montelukast;
  • Simpler;
  • Singulex;
  • Singular;
  • Ektalust.

Similar medicines:

Other medicines:
Reviews (37):
Guests
Elyona Starushko
Hello! Whether it is necessary to continue reception singlona if the child 7 years was ill ORVI or it is necessary to make a break for the period of treatment,and then continue to receive Singlon? Thank you in advance.
Administrators
admin
Elyona Starushko, The reception of the drug Singlon in ARVI or even the flu is not necessary to stop, there is no need to take breaks either. Continue treatment with the same dosage that the doctor advised you and let the baby recover.
Guests
mariya vasilevskaya
Hello, tell me, what does it mean to take in the evening? Is it before bedtime or can it be hours already at five or six in the evening? It is written that it does not depend on the food intake and then the hourly instructions associated with food. Is it important or can you just give it in the evening before going to bed half an hour after the child (4 years) ate?
Administrators
admin
mariya vasilevskayaYou can take Singlon according to this scheme as described in the question. This is unprincipled.
Guests
olesya
Hello, tell me, if we started treatment with Singular, but because of the high price we want to go to Singlon, is it possible? And he will help with an allergic rhinitis like the Singular? Why is it written in Singlon's testimony only about asthma,although it contains the same components as the Singular.
Administrators
admin
olesya, Sami also answered their own question. Singlon is an absolute analogue of the active substance of the preparation Singular. The component is the same, and the difference in instructions is because manufacturers put their research into effectiveness in the instructions from different diseases and they each have their own. But once the active substance is one, so the therapeutic effects should be similar. If Singular helps you with an allergic rhinitis, then there is a high probability that Singlon will also help.
Visitors
Hi
Hello tell me, please, my son is 3 years old, our doctor prescribed us a singlet 4 mg, or singular 4 mg, I did not find this dosage, I was told in the drugstore that 10 mg can be divided into several parts and given once a day, which I did for 4 days, but our doctor said that you can not just 4 mg. How now to be? What I gave can be dangerous for the child and can I now buy a 4 mg singles and continue the reception? His son started snot again and his throat is troubled,singlon to us have registered after frequent ORZ and tussis together with inhalations and from an allergy too advised. Help, please, to understand.
Administrators
admin
Hi, All right to you the doctor said. Singlon and Singular are in a dosage of 4 mg. I can not even imagine how you can correctly divide the tablet 10 mg to 4 mg, at the pharmacy, of course, you were wrong to advise initially. Now buy the medicine in the right dosage and give it to the child as recommended by the doctor. Most likely, there should not be any negative consequences of such a method. You can only share the tablets in half. Sometimes in pharmacies can make powders from tablets and hang the correct dosage, but this is in those where there is a prescription department and unprotected tablets.
Visitors
Jeanne
Hello. Today we had a car-care "caring" and a doctor a pulmonologist without any tests and studies (83% did the "spygram" on the go), came home to read and gasped - how it is done and how we did it, after a hearty breakfast and the child took half an hour along the corridor played) on the move appointed Singular. Esteemed, pretty strong preparation almost for lifelong therapy ...and we came for the first time, the child a couple of weeks ago began to cough up seizures, at night. Whether it is necessary to drink this preparation, or all over again all over again to be surveyed?
Administrators
admin
JeanneThey did it right that they did not take Singlon. It is good, but all these screenings and other mass surveys should be conducted with only one purpose - to identify the problem. They found out - give the patient to qualified doctors who have diagnostic tools and proper qualifications, can diagnose and observe the child's condition in the future. And so I do not really understand who will be responsible for this appointment to your baby. In the road train you will not find the last ones.

So go to the pulmonologist (you can tell the doctor who will write to him about this screening and the available symptoms), there you will in any case repeat the analysis and, I want to believe, help.
Guests
Zauresh
Hello, I'm allergic to singling, I have bronchial asthma and allergic rhinitis, but I read the instructions for use and contraindications so much that it's scary to take.Especially frightened suicidal - it's so dangerous, how often it happens to patients, but I look and give the children?
Administrators
admin
Zauresh, The incidence of side effects is not greater than that of the drugs in this group. Suicidal means that at the time of testing Singlon someone from the experimental group committed suicide. And whether it was from the drug or not is not known, but the rules oblige to record all the negative aspects in side effects.

If the doctor recommended this remedy for asthma, you should try it, just watch your condition for the first time and note the negative aspects that you will then discuss with your doctor in order to determine where to go next.
Guests
Lena
My son went through the singlon course. The result is excellent, for a year did not hurt even once.
Guests
Zauresh
Thanks for the detailed explanation. Has already begun treatment, I feel well.
Visitors
Katrin_
Hello. At 10 years old son was diagnosed with bronchial asthma cough form. Have passed or have taken place course of treatment - has helped or assisted. The doctor warned that if there is a positive reaction to the flowering of cereals, it is possible that during this period the seizures will begin, but it did. And only in the autumn after orvi, that is, a year after the beginning of the first attack, he repeated. We started the procedure: the first tablet in the daytime (right after the purchase, since the paroxysmal attack did not take off), the next morning there is still a pill, and then I learn that the child himself and without the knowledge drank another night before the night before. It turns out an overdose. No negative symptoms yet, how dangerous is it and when is it better to give the next pill? A day after receiving the last, a day later in the evening or since the dose at the time of taking the last pill is actually increased threefold (that is, on the first day three tablets are drunk), then the day is missed. Thank you in advance.
Administrators
admin
Katrin_, I will begin with the fact that children up to 15 years of the drug Singlon in the form of tablets with a dosage of 10 mg is contraindicated. Better for these purposes, use chewable tablets 5 mg, specifically designed, including for use in children.

On the issue.Your child took it right, because Singlon tablets are taken 1 tablet per night, not by day or morning, as you tried to give him. If on this day you already gave the child a pill, then the next appointment should be carried out the next day at the due time. That is given in the morning, then give the next day in the evening and then follow the scheme prescribed by the doctor and the instruction. If there were no immediate side effects from an overdose of the medicine, it can be said with more certainty that there will not be any of them in the future. Chewing tablets Singlona accepted in a similar way.
Visitors
Antonina
Hello! My son (2 years old) was diagnosed with "Allergic rhinitis" and prescribed the drug Singlon. But we have problems with bronchial tubes, a cough and, thank God, no asthma. There are so many pimples that it's scary to take an adult, but here the little one was appointed. Whether he is appointed or nominated at similar diagnoses and whether it is necessary to give the kid?
Administrators
admin
AntoninaAt an allergic rhinitis to use preparation Singlon it is senseless both to children, and adults.On the mechanism of action, this drug leads to bronchodilation, that is, it expands the bronchi and prevents bronchospasm, which happens with asthma (bronchial or aspirin). So why the doctor appointed this drug for a cold to the child, it is necessary to find out from this specialist.
Guests
Leila
Good afternoon. My son, 4 years old, is diagnosed with bronchial asthma (suffocating with bronchitis). We have been drinking the Singlon course (2 months), there is a positive effect.
Guests
Alina Agarkova
Hello. Mom was given asthma for two years. Gradually it became better and very rarely attacks. She is now inhaling salmecort. But she has a strong tachycardia from him. I wanted to try a single, but he also has tachycardia in his side. How often does this side effect occur?
Administrators
admin
Alina Agarkova, I did not notice a similar side effect in my patients taking Singlon, but there are tachycardias in the side effects, so you need to try.Before changing the treatment regimens, one should be examined and make sure that the tachycardia is not caused by other causes, perhaps age.
Guests
Angelica
At us at reception of Singlon cough has begun after five days of reception. At the child of 5 years, an asthma of a physical strain.
Guests
Irina
With allergy reception singlona appointed?
Administrators
admin
Irina, The drug Singlon is not used for the treatment of allergies, but is used for bronchial or aspirin asthma, as well as for the prevention of bronchospasm.
Visitors
Ruslana
Hello. I have bronchial asthma. Six months ago, took Singlon for a month, seizures stopped until this winter. When going from cold to heat (for example, from the street I get on the bus) a cough starts and it is difficult to breathe. Again began to drink Singlon. I drank 2 packs. I wanted to stop, but the attacks immediately began again. Can I drink a third package? Would not this be considered addictive?
Administrators
admin
RuslanaSome patients Singlon and for 6 months appoint continuously. But if you yourself are treated then there is a risk, this is an uncontrolled reception and it is not known how it will end for your health.
Guests
Catherine Post
Good afternoon! Singlon was appointed as an allergist for the prevention of asthma, tk. the child has frequent obstructive bronchitis - only for the last six months 4 times.
After 4 days of taking the drug by a child (3 years 4 months), a dry cough started. After drug discontinuation - disappeared. Is dry cough a side effect? Do I need to continue treatment?
Administrators
admin
Catherine PostIf, after the withdrawal of the drug Singlon dry cough in the child disappears - this clearly indicates a side effect of the drug. In this case, you should contact your doctor for cancellation-replacement of the drug for another remedy.
Guests
Galina
Hello. My son is 5 years old, often has ARVI. The allergist after a blood test for immunoglobulin (at a rate of 60 units, in his son 160) appointed Singular 4 mg for 2 months to treat allergies.But this drug is expensive for me, can I replace it with Singlon (the composition is almost identical)?
Administrators
admin
Galina, Such a replacement is possible. The drug Singlon is an absolute analogue of Singular according to the active substance and can be replaced provided that the dosages of the taken tablets coincide.
Guests
masha.shepeleva
masha.shepeleva, Moved your question to the preparation of Singular, where it is more appropriate.
admin
Guests
Victoria
Hello. To the child 2,5 years, the doctor has diagnosed an adenoid 2 st on a background of an allergy, the child practically does not breathe a nose. Appointed nazoneks and singlon. Coughing is not at all, bronchitis has never been sick. Is it advisable to receive Singlon in this situation?
Administrators
admin
Victoria, Singlon is advisable to use to enhance the effects of Nazonex, but only in the presence of bronchial problems. In adenoids, the localization of the process at the beginning of the airways and the deep penetration of the local glucocorticosteroid Nazonex seems to me impractical,if other symptoms in the child is not observed, other than those described in the question. I would not appoint Singlon, but it is necessary to coordinate this question with a doctor (perhaps another), maybe he diagnosed something in addition to the child.
Guests
Lyudmila
Could you tell me if there have been any cures for aspirin asthma?
Administrators
admin
LyudmilaI have never seen such a thing in practice or in literature. If only in children, they sometimes get rid of their asthma in the process of growth (outgrowth).
Visitors
mnacig
Hello. Tell me, please, were at the allergist, has appointed or nominated 4 mg on 1 a chewing tablet for the night. The child is 3 years old. Over the past 4 months, 4 obstructive bronchitis + rhinitis + enlarged adenoids. The question is that my child does not want to take a pill at all. Is it possible to grind and add, for example, in porridge or diluted with water? Thank you in advance.
Administrators
admin
mnacig, There is an opinion that the way of use in the instruction should be executed literally, that is, a tablet under the tongue - it is necessary to dissolve under the tongue, chewable tablets - chew, etc. Try to force and persuade your baby that it will be easier for him not to see the doctors. If not, then grind and give with food. Based on the mechanism described in the manual, it is not good to act on this from Singlon, although I can not tell you this reliably.

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