Antisthene - instructions for use, reviews, analogs and form of release (20 mg tablets, prolonged action of CF 35 mg) of the drug for the treatment of coronary heart disease and other vascular disorders in adults, children and pregnancy. Alcohol

In this article, you can read the instructions for using the drug Antisthene. Comments of visitors of the site - consumers of this medication, as well as opinions of specialists on the use of Antistene in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analysts analogues in the presence of existing structural analogues.Use for the treatment of coronary heart disease and other vascular disorders in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Antisthene - a remedy that normalizes the energy metabolism of cells that have undergone hypoxia or ischemia. Prevents the decrease in intracellular content of ATP, ensures the normal functioning of membrane ion channels, transmembrane transfer of potassium and sodium ions and preservation of cellular homeostasis.

Trimetazidine (the active ingredient of the drug Antisten) slows the oxidation of fatty acids by selective inhibition of long chain 3-ketoacetyl-CoA thiolase, which leads to an increase in glucose oxidation and the restoration of conjugation between glycolysis and oxidative decarboxylation and has been shown to protect myocardium from ischemia. Switching of oxidation of fatty acids to glucose oxidation underlies antianginal action of trimetazidine.

In experimental studies on animals, it was shown that Antisthene supports the energymetabolism of the heart and neurosensory organs during episodes of ischemia; reduces the magnitude of intracellular acidosis and the degree of changes in the transmembrane ion flow that occurs with ischemia; reduces the level of migration and infiltration of polynucleated neutrophils in the ischemic and reperfusion tissues of the heart, reduces the size of myocardial damage; while it does not affect hemodynamics.

Composition

Trimetazidine dihydrochloride + excipients.

Pharmacokinetics

Antisten quickly and almost completely absorbed by the intestinal mucosa. Bioavailability is 90%. Binding to plasma proteins is 16%. It is excreted by the kidneys (about 60% - unchanged).

Indications

• IHD: prevention of angina attacks (in complex therapy);
• cochleovestibular disorders of ischemic nature, such as dizziness, tinnitus, hearing impairment;
• chorioretinal vascular disorders.

Forms of release

The tablets covered with a cover of 20 mg.

Tablets of prolonged action, coated with CF 35 mg.

Instructions for use and reception scheme

Take inside at a dose of 40-60 mg per day, the frequency of reception 2-3 times a day.The duration of therapy is set individually, depending on the clinical situation.

Long-acting CF tablets

Inside, during a meal.

Antisthenes MV appoint 1 tablet 2 times a day (morning and evening). The course of treatment is set by the doctor individually.

Side effect

• allergic reactions (including skin rash, itching);
• extrapyramidal disorders (tremor, rigidity, akinesia);
• dizziness;
• headache;
• asthenia;
• nausea, vomiting;
• diarrhea;
• dyspepsia;
• gastralgia.

Contraindications

• pregnancy;
• lactation period (breastfeeding);
• age under 18 years (effectiveness and safety not established);
• renal failure (CC less than 15 ml / min);
• Hypersensitivity to trimetazidine.

Application in pregnancy and lactation

Animal studies have not shown a teratogenic effect, but due to the lack of clinical data on the safety of the drug during pregnancy, the risk of fetal malformations can not be ruled out. The use of the drug Antistene during pregnancy is contraindicated.

It is not known whether Antistene is excreted in breast milk.If you need to use the drug during lactation, you should decide whether to stop breastfeeding.

Use in children

Contraindicated in children and adolescents under the age of 18 years (efficacy and safety not established).

special instructions

Do not use to stop angina attacks!

The drug is not indicated for the initial course of therapy for unstable angina or myocardial infarction.

It is not recommended to drink alcohol during treatment with Antistain (the opposite of the action of the active substances - ethanol and trimetazidine).

In the case of an attack of angina pectoris, the treatment should be reviewed and adapted.

If you skip one or more doses of the drug, you can not take a higher dose to the next dose.

Impact on the ability to drive vehicles and manage mechanisms

The drug Anti-Sten has no significant effect on the ability to drive vehicles and perform other jobs that require a high rate of psychomotor reactions.

Drug Interactions

There is no information about drug interaction.

Analogues of the drug Antisten

Structural analogs for the active substance:

• Angiosyl retard;
• Antistene CF;
• Depenorm MB;
• Carditrim;
• Metagard;
• Predizin;
• Preductal;
• Preductal MB;
• Precardard;
• Romekor;
• Rimecor MB;
• Tridoukard;
• Trimectal;
• Trimectal MB;
• Trimet;
• Trimetazide;
• Trimetazidine;
• Trimetazidine MB;
• Trimetazidine dihydrochloride;
• Trimitard MV.

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