Letrozole - instructions for use, analogs, reviews and release forms (tablets 2.5 mg) drugs for the treatment of malignant tumors and breast cancer in women, including during pregnancy. Composition

In this article, you can read the instructions for using the drug Letrozole. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Letrozole in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Letrozola in the presence of existing structural analogues. Use for the treatment of malignant tumors and breast cancer in women, as well as in pregnancy and lactation.Composition of the preparation.

Letrozole antitumor agent. It is a non-steroidal aromatase inhibitor, an enzyme that involves the synthesis of estrogens in postmenopausal women. Aromatase promotes the conversion of androgens synthesized in the adrenal glands (primarily androstenedione and testosterone), to estrone and estradiol. The inhibition of aromatase activity is realized by competitive binding to the subunit of this enzyme - heme cytochrome P450, which leads to a decrease in the biosynthesis of estrogens in all tissues, incl. in the tissues of estrogen-dependent tumors.

Composition

Letrozole + auxiliary substances.

Indications

• treatment of malignant breast tumors in women during natural or artificially induced menopause after anti-estrogen therapy.

Forms of release

Tablets, coated with a coating of 2.5 mg.

Instructions for use and dosing regimen

The dose is 2.5 mg once a day daily. Treatment continues during the period of progression of the disease.

Side effect

• headache;
• nausea, vomiting;
• peripheral edema;
• general weakness;
• tides;
• thinning hair;
• skin rash;
• dyspepsia;
• increase in body weight;
• musculoskeletal pain;
• anorexia;
• vaginal bleeding;
• leukorrhea;
• constipation;
• dizziness;
• increased appetite;
• increased sweating;
• dyspnea;
• thrombophlebitis;
• spotting from the vagina.

Contraindications

• endocrine status, characteristic of the premenopausal period;
• pregnancy;
• lactation;
• hypersensitivity to letrozole.

Application in pregnancy and lactation

Contraindicated in pregnancy, during lactation.

Use in children

Children are not used.

special instructions

In patients with SC less than 10 ml / min, the safety of letrozole has not been studied, therefore, when it is necessary to use it in such cases, the ratio between the expected therapeutic effect and the possible risk of treatment should be carefully weighed.

Before the start of therapy, it is desirable to study estrogen receptor status.

Under the influence of letrozole, the ability to concentrate attention and the speed of psychomotor reactions can be reduced, therefore it is recommended to avoid driving vehicles and other potentially dangerous activities during the treatment period.

Drug Interactions

With the simultaneous administration of letrozole with warfarin, no clinically significant interactions were observed.

The use of lapatinib in combination with letrozole does not affect the pharmacokinetic parameters of letrozole.

With concomitant administration of letrozole with cimetidine, clinically significant interactions were not observed.

Analogues of medicinal product Letrozole

Structural analogs for the active substance:

• Lestrodex;
• Letroza;
• Letrozole Teva;
• Letros;
• Letrotera;
• Nexazole;
• Auret;
• Femara;
• Extrase;
• The Estrolet;
• Etrusil.

Analogues for the pharmacological group (antitumor hormonal drugs):

• Anabrez;
• Anamasten;
• Anaster;
• Anastrozole;
• Andriol;
• Androkur;
• Aromasine;
• Bicalutamide;
• Bikaprost;
• Biel;
• Buserelin;
• Veraplex;
• Genfastat;
• Decapeptil;
• Depot Provera;
• Depostat;
• The Divigel;
• Zytiga;
• Zoladex;
• Climara;
• Letros;
• Letrotera;
• Mammoth;
• Nexazole;
• Novofen;
• Octreotide;
• Octrid;
• Organometr;
• Orimeten;
• Prajisan;
• Provera;
• Progesterone;
• Projest;
• Sandostatin;
• Selana;
• Sinestrol;
• Suprefact;
• Tamoxifen;
• Fazlodex;
• Fareston;
• Femara;
• Flutamide;
• Flucin;
• Egistrazole;
• Estimax;
• Estrogele;
• The Estrolet.

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