Novobismol - instructions for use, reviews, analogs and form of release (tablets 120 mg) drugs for the treatment of stomach and duodenal ulcers with Helicobacter in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Novobismol. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Novobismol in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Novobismola in the presence of existing structural analogs. Use to treat stomach and duodenal ulcers with Helicobacter in adults, children, as well as during pregnancy and lactation. Composition of the preparation.
Novobismol - Antiulcer with antibacterial activity against Helicobacter pylori (Helicobacter). It also has an anti-inflammatory and astringent effect. In the acidic environment of the stomach forms insoluble bismuth oxychloride and citrate, and also chelate compounds are formed with the protein substrate in the form of a protective film on the surface of ulcers and erosions. Increasing the synthesis of prostaglandin E, the formation of mucus and the secretion of bicarbonate, stimulates the activity of cytoprotective mechanisms, increases the stability of the mucous membrane of the gastrointestinal tract to the effects of pepsin, hydrochloric acid (hydrochloric acid), enzymes and bile salts. It leads to the accumulation of the epidermal growth factor in the defect area. Reduces the activity of pepsin and pepsinogen.
Composition
Bismuth tricalcium dicitrate + auxiliary substances.
Pharmacokinetics
Novobismol is practically not absorbed from the digestive tract. However, a small amount of bismuth can enter the systemic circulation. It is excreted mainly with feces. An insignificant amount of bismuth, which enters the plasma, is excreted by the kidneys.
Indications
- peptic ulcer of the stomach and duodenum in the phase of exacerbation (including associated with Helicobacter pylori);
- chronic gastritis and gastroduodenitis in the phase of exacerbation (including associated with Helicobacter pylori);
- irritable bowel syndrome, mainly with symptoms of diarrhea;
- functional dyspepsia, not associated with organic gastrointestinal diseases.
Forms of release
Tablets coated with 120 mg.
Instructions for use and dosing regimen
Adults and children older than 4 years - inside 2-4 times a day for 30 minutes before meals. The dose depends on the age of the patient.
The course of treatment is 4-8 weeks. For the next 8 weeks, do not take drugs containing bismuth.
For the eradication of Helicobacter pylori, it is advisable to use bismuth tricalium dicitrate in combination with antibacterial drugs possessing anti-Helicobacter pylori activity.
Side effect
- nausea, vomiting;
- increased frequency of stools;
- constipation;
- skin rash;
- itching;
- encephalopathy associated with the accumulation of bismuth in the central nervous system.
Contraindications
- severe renal dysfunction;
- pregnancy;
- lactation period;
- hypersensitivity to bismuth tricalium dicitrate.
Application in pregnancy and lactation
Contraindicated in pregnancy and lactation (breastfeeding).
Use in children
It is used in children older than 4 years according to the dosing regimen.
special instructions
Do not use for more than 8 weeks.
During treatment it is not recommended to exceed the established daily doses for adults and children.
At the end of the course treatment at recommended doses, the concentration of active substance in the blood plasma does not exceed 3-58 μg / l, and intoxication is observed only at a concentration of more than 100 μg / l.
Against the background of application, it is possible to stain the feces black due to the formation of bismuth sulphide. Sometimes there is a slight darkening of the tongue.
Drug Interactions
With the simultaneous administration of other medicines, as well as food and liquids, in particular antacids, milk, fruits and fruit juices, a change in the efficiency of bismuth in tricalium dicitrate is possible.
Analogues of Novobysmol
Structural analogs for the active substance:
- Ventrisol;
- Bismuth tricalcium dicitrate;
- De Nol;
- Novobispol.
Analogues for the pharmacological group (gastroprotectors):
- Alsukral;
- Ankrusal;
- Venter;
- Ventrisol;
- Bismuth is the basic nitrate;
- Bismuth tricalcium dicitrate;
- De Nol;
- Caeopectate;
- Neointestopan;
- Rebambid Macleodz;
- Sucralfate;
- Sukrat;
- Ugastran.
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