Tioctacid - instructions for use, reviews, analogs and release forms (tablets 600 mg BV, injections in ampoules for injections T) for the treatment of cirrhosis, hepatitis and fatty liver disease in adults, children and in pregnancy
In this article, you can read the instructions for using the drug Tioctacide. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Tioctacida in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Tioctacide in the presence of existing structural analogues. Use for the treatment of cirrhosis, hepatitis and fatty liver disease in adults, children, as well as during pregnancy and lactation.
Tioctacide metabolic drug.Thioktovaya (alpha-lipoic) acid (active ingredient of the preparation Tioctacid) is contained in the human body, where it performs the function of coenzyme in the reactions of oxidative phosphorylation of pyruvic acid and alpha-keto acids. Thioctic acid is an endogenous antioxidant, according to the biochemical mechanism of action it is close to the Vitamins of group B.
Tioctacid helps protect cells from the toxic effects of free radicals that arise in metabolic processes; it also detoxifies exogenous toxic compounds that have penetrated the body. Thioctic acid increases the concentration of endogenous antioxidant glutathione, which leads to a decrease in the severity of symptoms of polyneuropathy.
The drug has hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic action; improves trophic neurons. The result of the synergistic action of thioctic acid and insulin is an increase in the utilization of glucose.
Thiocytase BV (rapid release) is an optimized dosage form for oral administration that avoids high variability in absorption,guarantees a stable level of thioctic acid in the blood plasma and high bioavailability.
Composition
Thioktovaja (alpha-lipoevaja) acid + auxiliary substances (tablets).
Tioctata trometamol + auxiliary substances (ampoules).
Pharmacokinetics
When taking Tioctacid (rapid release), thioctic acid is quickly and completely absorbed from the digestive tract. Simultaneous intake of food can reduce absorption of the drug. The absolute bioavailability of thioctic acid is 20%. Exposed to the effect of "first passage" through the liver. The main pathways of metabolism are oxidation and conjugation. Thioctic acid and its metabolites are excreted in the urine (80-90%).
Indications
- chronic hepatitis;
- fibrosis and cirrhosis of the liver;
- fatty degeneration of the liver;
- toxic effects of metals;
- diabetic polyneuropathy;
- alcoholic polyneuropathy;
- cerebral infarction or stroke;
- Parkinson's disease;
- Diabetic retinopathy and diabetic macular edema;
- glaucoma;
- lesions of the intervertebral disc and other parts of the spine with radiculopathy.
Forms of release
Tablets coated with 600 mg of BV (sometimes mistakenly called capsules).
Solution for intravenous administration (injections in ampoules for injection).
Instructions for use and dosing regimen
Pills
Inside appoint 600 mg (1 tablet) 1 time per day. Tablets are taken on an empty stomach, 30 minutes before breakfast, without chewing and washing with water.
In severe cases, treatment begins with the appointment of a solution for intravenous administration of Tioctacid 600 T for 2-4 weeks, then the patient is transferred to the treatment with a tablet drug Tioctacid BV.
Ampoules
The drug is used intravenously. The recommended dose for severe polyneuropathy is 600 mg (1 ampoule) once a day for 2-4 weeks.
In the future, the patient is transferred to treatment with a drug Tioctacid BV in a dose of 600 mg (1 tablet) per day.
Rules for the preparation and administration of an infusion solution
The drug Tioktatsid 600 T can be used as infusions (droppers) in a 0.9% solution of sodium chloride (the volume of infusions is 100-250 ml) for 30 minutes. The infusion solution should be protected from light (for example, by wrapping the vessel with aluminum foil). The solution for intravenous administration, protected from light, is suitable for 6 hours.
In / in the administration of the drug should be done slowly (no faster than 2 ml / min).It is also possible to / to inject an undiluted solution with an injection syringe and perfusor. In this case, the administration time should be at least 12 minutes.
Due to the sensitivity of the active substance to light, the ampoule should be removed from the carton immediately before use.
Side effect
- nausea, vomiting;
- pain in the stomach and intestines;
- diarrhea;
- change in taste;
- skin rash;
- hives;
- itching;
- anaphylactic shock;
- dizziness;
- allergic reactions at the site of infusions;
- symptoms of hypoglycemia (confusion, increased sweating, headache, visual disturbances).
Contraindications
- pregnancy (there is insufficient experience of the drug);
- the period of breastfeeding (there is insufficient experience in using the drug);
- children and adolescence (there are no clinical data on the use of the drug in children and adolescents);
- hypersensitivity to thioctonic (alpha-lipoic) acid and other components of the drug.
Application in pregnancy and lactation
Contraindicated the use of the drug Tioktatsid during pregnancy and lactation, tk.there is insufficient experience in using the drug during these periods.
Use in children
Contraindicated in children and adolescents (there are no clinical data on the use of the drug in children and adolescents).
special instructions
Alcohol consumption is a risk factor for the development of polyneuropathy and may reduce the effectiveness of Tioctacid BV, so patients should refrain from taking alcoholic beverages during treatment with the drug or during periods outside of treatment.
Treatment of diabetic polyneuropathy should be conducted against the background of maintaining the optimal concentration of glucose in the blood.
By accelerating the metabolism can be used in combination with other drugs to treat metabolic metabolic disorders and weight loss.
Due to the fact that thioctic acid binds metals, and tablets Tioctacide BV take 30 minutes before breakfast, preparations containing metals should be taken at lunch or in the evening. For the same reason, during the treatment with Tioctacid BV, the use of dairy products is recommended only in the afternoon.
When taking the drug, urine can acquire a specific odor.
Influence on ability to drive vehicles, mechanisms
The impact on the ability to drive vehicles and mechanisms has not been specifically studied.
Drug Interactions
With the simultaneous administration of thioctic acid and cisplatin, Cisplatin is less effective.
Thioktovaya (alpha-lipoic) acid binds metals, so do not prescribe concurrently with preparations containing metals (such as iron, magnesium, calcium) and dairy products. The interval between receptions should be at least 2 hours.
With the simultaneous use of Tioctacid and insulin or oral hypoglycemic drugs, their effect may be increased, so regular monitoring of blood glucose levels, especially at the beginning of thioctic acid therapy, is recommended. In some cases it is permissible to reduce the dose of hypoglycemic drugs in order to avoid the development of symptoms of hypoglycemia.
Ethanol (alcohol) and its metabolites weaken the action of thioctic acid.
Pharmaceutical interaction
The infusion solution of thioctic acid is incompatible with the Dextrose solution, Ringer's solution and with solutions reacting with disulfide and S-groups, ethanol.
Analogues of the drug Tioctacid
Structural analogs for the active substance:
- Alpha-lipoic acid;
- Berlition 300;
- Berlition 600;
- Lipamid;
- Lipoic acid;
- Liptiokson;
- Neurolephone;
- Octolipen;
- Tiogamma;
- Thiocacid 600 T;
- Tioctacide BV;
- Thioctic acid;
- Thiolept;
- Thiolipone;
- Espa Lipon.
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