Octolipen - instructions for use, analogs, reviews and release forms (300 mg capsules, 600 mg tablets, injections for injections) for the treatment of hepatitis, liver cirrhosis and weight loss in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Octalipen. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Octolipen in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Oktolipen in the presence of existing structural analogues. Use to treat hepatitis, liver cirrhosis and weight loss in adults, children, as well as during pregnancy and lactation. Composition of the preparation.
Octalipen - endogenous antioxidant (binds free radicals), in the body is formed during the oxidative decarboxylation of alpha-keto acids. As a coenzyme mitochondrial multienzyme complexes is involved in the oxidative decarboxylation of pyruvic acid and alpha-keto acids. Helps reduce blood glucose and increase glycogen content in the liver, as well as overcome insulin resistance. By the nature of the biochemical effect, thioctic acid is close to the Vitamins of group B. It participates in the regulation of lipid and carbohydrate metabolism, stimulates the exchange of cholesterol, improves liver function.
Has hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic action. Improves trophic neurons and axonal conductivity, reduces the manifestations of diabetic and alcoholic polyneuropathy.
Composition
Thioktovaya (alpha-lipoic) acid + auxiliary substances.
Pharmacokinetics
When ingested quickly and fully absorbed, taking with food simultaneously reduces absorption. Bioavailability - 30-60% due to the effect of "first passage" through the liver. Metabolized in the liver by side chain oxidation and conjugation.Thioctic acid and its metabolites are excreted by the kidneys (80-90%).
Indications
- diabetic polyneuropathy;
- alcoholic polyneuropathy;
- cirrhosis of the liver;
- hepatitis (chronic hepatitis);
- prevention and treatment of atherosclerosis (hypolipidemic effect);
- weight loss (due to the normalization of fat metabolism);
- fatty degeneration of the liver;
- intoxication (including salts of heavy metals), poisoning with pale toadstool.
Forms of release
Capsules 300 mg.
Tablets coated with 600 mg.
Concentrate for the preparation of a solution for infusions (injections in ampoules for injections).
Instructions for use and dosing regimen
Capsules
The drug is taken orally, on an empty stomach, 30 minutes before the first meal, without chewing and drinking with a sufficient amount of water.
The recommended dose is 600 mg (2 capsules) once a day.
The duration of the course of treatment is determined by the doctor.
Pills
The drug is taken orally, on an empty stomach, 30 minutes before meals. Tablets should be swallowed whole, without chewing, squeezed with enough liquid.
The recommended dose is 1 tablet (600 mg) once a day.
It is possible to perform stepwise therapy: oral administration of the drug begins after a 2-4-week course of parenteral administration of thioctic acid.The maximum course of taking tablets is 3 months. In some cases, Otoplipen therapy involves longer-term use. Duration of admission is determined by the attending physician.
Ampoules
To prepare an infusion solution, 1-2 ampoules (300-600 mg) of the drug are diluted in 50-250 ml of 0.9% sodium chloride solution. The final solution is intravenously dripped (in the form of a dropper). Apply 300-600 mg once a day for 2-4 weeks. Later on they switch to oral therapy.
The preparation possesses photosensitivity, therefore it is necessary to take ampoules from the package just before use. It is advisable to protect the bottle with solution from light during the infusion (light-protective bags, aluminum foil can be used). The prepared solution should be stored in a dark place and used for a maximum of 6 hours after cooking.
Side effect
- hives;
- systemic allergic reactions (up to the development of anaphylactic shock);
- development of symptoms of hypoglycemia (due to improved glucose uptake);
- convulsions;
- diplopia;
- point bleeding in mucous membranes, skin;
- thrombocytopathy;
- hemorrhagic rash (purpura);
- thrombophlebitis;
- with rapid intravenous administration, an increase in intracranial pressure (the appearance of a feeling of heaviness in the head), difficulty breathing;
- nausea, vomiting;
- heartburn;
- abdominal pain;
- diarrhea.
Contraindications
- pregnancy;
- lactation period (breastfeeding);
- children and adolescents under 18 years of age (efficacy and safety of use not established);
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
The use of the drug Oktalipen during pregnancy and during lactation is contraindicated.
Use in children
Contraindicated in children and adolescents under the age of 18 years (efficacy and safety not established).
special instructions
Patients with diabetes require frequent monitoring of blood glucose, especially at the beginning of treatment. In some cases, a reduction in the dose of hypoglycemic agents is required.
During treatment, you must strictly refrain from drinking alcohol, because ethanol reduces the therapeutic efficacy of thioctic acid.
Drug Interactions
Octolipen (in the form of a solution for infusions) leads to a decrease in the effect of cisplatin.
When used simultaneously with insulin and / or oral hypoglycemic agents, an increase in the hypoglycemic effect is observed.
Thioctic acid forms hardly soluble complex compounds with sugar molecules. The prepared solution is incompatible with glucose solution, levulose, Ringer's solution, as well as with compounds (including their solutions) reacting with disulfide and SH-groups.
Analogues of the drug Oktilipen
Structural analogs for the active substance:
- Alpha-lipoic acid;
- Berlition 300 and 600;
- Lipamid tablets;
- Lipoic acid;
- Liptiokson;
- Neurolephone;
- Tiogamma;
- Thiocacid 600;
- Thioctic acid;
- Thiolept;
- Thiolipone;
- Espa Lipon.
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