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Octolipen - instructions for use, analogs, reviews and release forms (300 mg capsules, 600 mg tablets, injections for injections) for the treatment of hepatitis, liver cirrhosis and weight loss in adults, children and pregnancy. Composition

Octolipen - instructions for use, analogs, reviews and release forms (300 mg capsules, 600 mg tablets, injections for injections) for the treatment of hepatitis, liver cirrhosis and weight loss in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Octalipen. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Octolipen in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Oktolipen in the presence of existing structural analogues. Use to treat hepatitis, liver cirrhosis and weight loss in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

 

Octalipen - endogenous antioxidant (binds free radicals), in the body is formed during the oxidative decarboxylation of alpha-keto acids. As a coenzyme mitochondrial multienzyme complexes is involved in the oxidative decarboxylation of pyruvic acid and alpha-keto acids. Helps reduce blood glucose and increase glycogen content in the liver, as well as overcome insulin resistance. By the nature of the biochemical effect, thioctic acid is close to the Vitamins of group B. It participates in the regulation of lipid and carbohydrate metabolism, stimulates the exchange of cholesterol, improves liver function.

 

Has hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic action. Improves trophic neurons and axonal conductivity, reduces the manifestations of diabetic and alcoholic polyneuropathy.

 

Composition

 

Thioktovaya (alpha-lipoic) acid + auxiliary substances.

 

Pharmacokinetics

 

When ingested quickly and fully absorbed, taking with food simultaneously reduces absorption. Bioavailability - 30-60% due to the effect of "first passage" through the liver. Metabolized in the liver by side chain oxidation and conjugation.Thioctic acid and its metabolites are excreted by the kidneys (80-90%).

 

Indications

  • diabetic polyneuropathy;
  • alcoholic polyneuropathy;
  • cirrhosis of the liver;
  • hepatitis (chronic hepatitis);
  • prevention and treatment of atherosclerosis (hypolipidemic effect);
  • weight loss (due to the normalization of fat metabolism);
  • fatty degeneration of the liver;
  • intoxication (including salts of heavy metals), poisoning with pale toadstool.

 

Forms of release

 

Capsules 300 mg.

 

Tablets coated with 600 mg.

 

Concentrate for the preparation of a solution for infusions (injections in ampoules for injections).

 

Instructions for use and dosing regimen

 

Capsules

 

The drug is taken orally, on an empty stomach, 30 minutes before the first meal, without chewing and drinking with a sufficient amount of water.

 

The recommended dose is 600 mg (2 capsules) once a day.

 

The duration of the course of treatment is determined by the doctor.

 

Pills

 

The drug is taken orally, on an empty stomach, 30 minutes before meals. Tablets should be swallowed whole, without chewing, squeezed with enough liquid.

 

The recommended dose is 1 tablet (600 mg) once a day.

 

It is possible to perform stepwise therapy: oral administration of the drug begins after a 2-4-week course of parenteral administration of thioctic acid.The maximum course of taking tablets is 3 months. In some cases, Otoplipen therapy involves longer-term use. Duration of admission is determined by the attending physician.

 

Ampoules

 

To prepare an infusion solution, 1-2 ampoules (300-600 mg) of the drug are diluted in 50-250 ml of 0.9% sodium chloride solution. The final solution is intravenously dripped (in the form of a dropper). Apply 300-600 mg once a day for 2-4 weeks. Later on they switch to oral therapy.

 

The preparation possesses photosensitivity, therefore it is necessary to take ampoules from the package just before use. It is advisable to protect the bottle with solution from light during the infusion (light-protective bags, aluminum foil can be used). The prepared solution should be stored in a dark place and used for a maximum of 6 hours after cooking.

 

Side effect

  • hives;
  • systemic allergic reactions (up to the development of anaphylactic shock);
  • development of symptoms of hypoglycemia (due to improved glucose uptake);
  • convulsions;
  • diplopia;
  • point bleeding in mucous membranes, skin;
  • thrombocytopathy;
  • hemorrhagic rash (purpura);
  • thrombophlebitis;
  • with rapid intravenous administration, an increase in intracranial pressure (the appearance of a feeling of heaviness in the head), difficulty breathing;
  • nausea, vomiting;
  • heartburn;
  • abdominal pain;
  • diarrhea.

 

Contraindications

  • pregnancy;
  • lactation period (breastfeeding);
  • children and adolescents under 18 years of age (efficacy and safety of use not established);
  • hypersensitivity to the components of the drug.

 

Application in pregnancy and lactation

 

The use of the drug Oktalipen during pregnancy and during lactation is contraindicated.

 

Use in children

 

Contraindicated in children and adolescents under the age of 18 years (efficacy and safety not established).

 

special instructions

 

Patients with diabetes require frequent monitoring of blood glucose, especially at the beginning of treatment. In some cases, a reduction in the dose of hypoglycemic agents is required.

 

During treatment, you must strictly refrain from drinking alcohol, because ethanol reduces the therapeutic efficacy of thioctic acid.

 

Drug Interactions

 

Octolipen (in the form of a solution for infusions) leads to a decrease in the effect of cisplatin.

 

When used simultaneously with insulin and / or oral hypoglycemic agents, an increase in the hypoglycemic effect is observed.

 

Thioctic acid forms hardly soluble complex compounds with sugar molecules. The prepared solution is incompatible with glucose solution, levulose, Ringer's solution, as well as with compounds (including their solutions) reacting with disulfide and SH-groups.

 

Analogues of the drug Oktilipen

 

Structural analogs for the active substance:

  • Alpha-lipoic acid;
  • Berlition 300 and 600;
  • Lipamid tablets;
  • Lipoic acid;
  • Liptiokson;
  • Neurolephone;
  • Tiogamma;
  • Thiocacid 600;
  • Thioctic acid;
  • Thiolept;
  • Thiolipone;
  • Espa Lipon.

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Reviews (26):
Administrators
admin
Visitor question Tatyana Maidanova, moved to the required section:
Diabetes. Appointed amaryl2.The neurologist recommended actovegin or octolipen. What is better to take in my case? Sugar became 5,4-6,2.

Tatyana MaidanovaWhether an illiterate question, or an illiterate appointment of treatment. Amaryl is a basic drug for the treatment of type 2 diabetes. It turns out that you compare it with Actovegin and Oktolipen, which are drugs of another class: Actovegin - an antihypoxant, Octolipen - an antioxidant. In general, you need to clarify the treatment of a doctor or change a doctor, since the appointment or statement of the question is terrible.
Guests
Amalia
In a hospital, instead of cytoflavin, glucose was dripped octolipen, as an analog, on glucose. Assigned cardiovascular in \ in, and then euphyllin in \ in. I do not have diabetes. Lied with a diagnosis of radiculopathy at all levels of the spine, d2, cerebral ischemia, cerebral hydrocephalus, atherosclerosis of the heart vessels - as a result, there were pains in the heart (which was not before the treatment), an increase in intracranial pressure and intraocular pressure, a pain in the eyes (eye fundus) .
Guests
Zimfira
Amalia. Octolipen is close in composition to the vitamins of group B.Well tolerated. Contraindicated to people who are allergic to vitamin B. If you have all these symptoms are proven by objective medical data, then do not apply. Perhaps the reaction gave the euphillin, it often leads to tachycardia, and then further along the chain - an excessive influx of blood into the brain, headache, pain in the eyes. I'm not a doctor, but in life with me the same thing was. I love this drug. In a year two times I am treated by courses. He helps one lose weight in one, an eternal problem for women.
Visitors
mihalevasveta
Hello! I octolipen 300 mg 1 r / d and omeganol 2 to * 3p / d 3 months, prescribed a dermatologist for hair loss! All analyzes are normal. Help or assist to understand, whether these medicines help or assist in my case?
Administrators
admin
mihalevasveta, Omeganol is a dietary supplements, contains fish oil, if you really want to take it, you can either that or another. Fat will be cheaper and you can drink domestic, there will not be a difference. As for Octolipen, too, will not be superfluous, many dermatologists in skin diseases (and hair are also related to the skin) is responsible for abnormal liver function, so they are appointed since Soviet times.Sometimes it helps, but this is empirical therapy based on the experience of a doctor.

I would advise you to do FGD of the stomach and duodenum and tests for trace elements (iron, ferritin, magnesium and other microelements and electrolytes), sometimes in these analyzes you can find the causes of hair loss, and also check the thyroid gland.
Guests
Lyudmila
Hello. I have a complication of diabetes mellitus 1m on insulin. A dropper is made octolipen + actovegin. Do I have a question whether the drugs are compatible? Thank you.
Administrators
admin
Lyudmila, Oktolipen and Actovegin can be taken together, according to experience and instructions, no side effects should be taken with a joint admission. Only Actovegin in the instruction has a clarification that interaction in one solution with other drugs has not been tested, so mixing them in a single dropper is not recommended. It is better to administer these drugs separately in two droppers, and not mix in one. Although many doctors risk and prescribe everything in one bottle, that is, they experiment, which I think is not entirely correct with respect to patients.
Guests
Gulnora
I use 300 mg capsules for the skin, I dissolve with water. Whether it is possible so to use okolipen. If the body is healthy mono whether to drink octopilen capsules to rejuvenate the body?
Guests
Natalia K.
I have type 2 diabetes mellitus, autoimmune primary biliary cirrhosis class A in Child-drink, autoimmune hepatitis. My legs swelled badly, I could hardly move them, there was a feeling that these were not my legs, but heavy pedestals. In hospital in August 2014, I was swept by the course of octopilen and the feeling of heaviness in my legs was gone, they became easy, you can say that my legs returned to me. Edema also passed. The effect has been holding for two years.
Administrators
admin
GulnoraSelf-medication I never and do not comment here, because I do not let go of my sins. Medicines must be taken according to the testimony, and if so, it is a waste of money, time and health. In occasion of dissolving in water a powder from Oktolipen capsules and rubbing into the skin - this is generally nonsense, because this drug must be absorbed into the blood and triggered at the liver level. Not an external medicine.
Guests
Tatyana
From octopilenum it is possible to add in weight ie. get better?
Administrators
admin
Tatyana, Hardly. There are no side effects of this kind, and I have never met such an experience. There are thin with the use of hepatoprotectors, this is observed, but that's to get better - this did not notice.
Guests
Naila Shagimardanova
I was lying in neurology with a diagnosis of facial nerve neuropathy. In addition to the basic treatment, I dripped octolipen (from the words m / s). In a bottle with magnesium solution, sulfate was poured from the syringe with a cloudy yellow solution and dripped accelerated. A minute later, I felt a weight under the sternum and frontal part of my head. After this dropper I felt heaviness and weakness. The doctor came in quickly, and left - smile, squint your eyes. While I opened my eyes in the ward, I no longer exist. She was discharged from the hospital and later got into pulmonology with atypical pneumonia, sarcoidosis in doubt. The cause can not be determined, now on hormones. And there is no improvement.
Visitors
Venustas
This drug was prescribed by a neurologist for the treatment of numbness in the fingers of the right hand. There are no such indications in the instruction. Will it be effective?
Administrators
admin
Venustas, Neuropathy in the testimony - this is it. Neurologists often use Octolipen in their treatment regimens, as the drug improves neuronal trophism and axonal conduction, which, it can be assumed, is necessary in your case.
Visitors
Atasik
At me an alternating lameness, 10 drips trental + actovegin were appointed or nominated. Then in the tablets began taking Oktilipen (600) and trental (400) once a day in the morning. On the third and fourth day, by the evening, suddenly suddenly it becomes bad for me, my lips grow numb, my consciousness somehow floats away, my weight in the abdomen, the pressure drops to 118/77 (checked), there are no other anomalies. I have working pressure 150/88 (67 years old, arteriosclerosis of blood vessels).
My doctor went on vacation. There is no one to consult with. Can I reduce the dosage of octopilen? I have benefited from Trental for several years, but for the first time it is okolipen, therefore I sin on it.
Administrators
admin
Atasik, Oktalipen I would at all for the time being canceled and left only Trental. So you can unequivocally determine - the reason of your bad state of health in the reception of the Okolipen or in something else. Reducing the dosage will most likely not help, because the description of the problem seems to be an allergic reaction to taking one of the medications.
Guests
Lyudmila
I have type 2 diabetes. The therapist prescribed octolipen (600 mg). In addition, I am hypertensive, I accept losartan (lorist). After taking octopilen, the pressure is very low, and in general, some depressed state. Could this be somehow connected?
Guests
Irina
For the first time she began taking octolipen according to the doctor's prescription. After taking the pill in the stomach starts burning strong, seconds 30.
Administrators
admin
LyudmilaPerhaps this is how your individual reaction to the Oktolipen drug manifests itself in your case. Also, you can not exclude an allergic reaction, in which a drop in blood pressure is possible.If the connection with taking the drug and the pressure drop is determined, it is clearly necessary to replace the drug with another and adjust the treatment regimen.
Visitors
MashaM
Hello. The doctor has appointed or nominated to me Okolipen in the form of intravenous injections, instead of drip (in the form of a dropper). Tell me, please, can I take the drug in / in the injections?
Administrators
admin
MashaM, The instructions say unequivocally that Octolipen can be used either orally in the form of capsules, or as a solution for infusions, that is, drip infusions in the form of droppers. About the intravenous route of administration in its classical understanding in the instructions to the drug there are no references. It is worth checking with your doctor about this appointment, whether there is an error.
Administrators
admin
Feedback from the site visitor Tamara Lovitsyna moved to the required section:
She took the drug Oktalipen, appointed neurologist. Later the reception of this drug was confirmed by a rheumatologist.But I could not take it for more than 2 weeks - after taking it in the morning on an empty stomach I felt very bad - a loss of strength, drowsiness, nausea, as if a glucose level had fallen or something like that and I went to bed. Then the discharge of blood began to appear in the nose, and one day my head began to ache - like the increase in intracranial pressure (unbearable pain in the frontal part and then across my head) - I thought I would not live to see it in the morning. And it began with the Octolipen. I canceled his appointment.
Guests
Tatyana
When do droppers with octolipids need to be closed from the light? Thank you.
Administrators
admin
TatyanaIt is necessary to protect the Octolipen flasks from the light and this is well described in the instructions.
Guests
Love
I have type 2 diabetes on insulin. Accepted Oktolipen, felt good. It took 3 months, again headaches and leg cramps. Together with Oktolipenom I took carbamazepine.

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