Ibupen - instructions for use, analogs, reviews and release forms (suspension or syrup for oral administration, tablets, suppositories) medications for the treatment of pain and as a febrifuge for influenza, ARVI in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Ibufen. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Ibufen in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ibufen in the presence of existing structural analogues.Use for the treatment of pain and as an antipyretic for influenza, SARS in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Ibufen non-steroidal anti-inflammatory drug (NSAID). It has antipyretic, analgesic and anti-inflammatory effect.

The mechanism of action is associated with a decrease in the synthesis of prostaglandins due to inhibition of cyclooxygenase activity, which catalyzes the conversion of arachidonic acid into prostaglandins. Ibufen inhibits the synthesis of glycoproteins, and also prevents the release of inflammatory mediators. The antipyretic effect of the drug is associated with a decrease in the level of prostaglandin E2 in the hypothalamus.

The analgesic effect of the drug is more pronounced for inflammatory pains.

Antipyretic and analgesic effect is manifested earlier and in smaller doses than anti-inflammatory effect, which develops on the 5th-7th day of treatment.

Antipyretic effect begins 30 minutes after taking the drug, the maximum effect is observed after 3 hours.

Like other NSAIDs, Ibufen has antiplatelet activity.

Composition

Ibuprofen + excipients.

Pharmacokinetics

After ingestion, more than 80% of Ibufen is absorbed from the digestive tract. Binding to blood plasma proteins (mainly with albumins) is 90%. Ibuprofen slowly penetrates into the joint cavities. The maximum concentration in the synovial fluid is observed 5-6 hours after ingestion. The decrease in the concentration of ibuprofen in the synovial fluid is slowed compared to that in blood plasma. Ibuprofen does not cumulate in the body. Biotransformed, mainly in the liver. 60-90% is excreted in the urine in the form of metabolites and the products of their compound with glucuronic acid. After taking a single dose, ibuprofen is completely removed within 24 hours.

Indications

• elevated body temperature in febrile states of various genesis (including acute respiratory viral infections, influenza, childhood infections, post-vaccination reactions);
• pain syndrome of various etiologies (including sore throat, headache, migraine, toothache, neuralgia, myalgia, painful teething, postoperative pain, post-traumatic pain, algodismenorrhea);
• inflammatory and degenerative diseases of the joints and spine (including rheumatoid arthritis, juvenile arthritis, ankylosing spondylitis).

Forms of release

Suspension for oral administration (sometimes mistakenly referred to as syrup).

Other dosage forms, be it tablets or rectal suppositories, did not exist at the time of drug description in the reference book.

Instructions for use and dosage

The drug is taken orally after a meal. Before use, the vial should be shaken until a uniform suspension is obtained.

The dose is determined depending on the age and body weight of the child. When calculating the dose, it should be taken into account that 5 ml of the suspension contain 100 mg of ibuprofen. The average single dose is 5-10 mg / kg of the child's body weight 3-4 times a day. The maximum daily dose is 20-30 mg / kg body weight.

Reception of the drug can be repeated every 6-8 hours. Do not exceed the maximum daily dose.

The antipyretic effect of Ibufen develops only 30 minutes after ingestion and lasts for 6-8 hours. The patient should be warned that if there is no antipyretic effect within 2 days and the analgesic effect within 3 days, see a doctor.

Children between 6 months and 1 year of age can be prescribed only by a doctor.

Side effect

• nausea, vomiting;
• stomach ache;
• constipation, diarrhea;
• erosive and ulcerative lesions of the gastrointestinal tract (including those complicated by hemorrhage);
• headache;
• dizziness;
• drowsiness;
• disorientation;
• depression;
• visual impairment (toxic amblyopia);
• aseptic meningitis;
• thrombocytopenia, agranulocytosis;
• impaired renal function;
• hives;
• rash;
• itching;
• bouts of bronchospasm (in predisposed patients).

Contraindications

• peptic ulcer of the stomach and duodenum in the phase of exacerbation;
• seizures of bronchospasm associated with taking acetylsalicylic acid or other NSAIDs (in the anamnesis);
• polyps of the nose;
• angioedema;
• hearing loss;
• hemophilia, blood clotting disorders, hemorrhagic diathesis;
• deficiency of glucose-6-phosphate dehydrogenase;
• severe liver dysfunction;
• severe renal dysfunction;
• severe heart failure;
• arterial hypertension;
• children's age up to 6 months (body weight less than 7 kg);
• increased sensitivity to ibuprofen or other NSAIDs, as well as to the auxiliary components of the drug.

Application in pregnancy and lactation

The administration of Ibufen during pregnancy is possible only if the potential benefit to the mother exceeds the possible risk to the fetus.

If it is necessary to appoint Ibufen during lactation, the question of stopping breastfeeding should be resolved.

Use in children

Contraindicated in children under 6 months of age (body weight less than 7 kg).

Children between 6 months and 1 year of age can be prescribed only by a doctor.

special instructions

With caution appoint Ibufen to a patient with heart failure, hypertension, with blood clotting disorders, with impaired liver and / or kidney function. Care should be taken when using the drug in patients with bronchial asthma and other obstructive lung diseases due to the fact that when using Ibufen, the risk of bronchospasm increases.

Admission of Ibufen may cause undesirable effects in patients with diabetes mellitus, malabsorption syndrome, fructose intolerance, with a deficiency of sucrose isomaltose.

With the use of ibuprofen in clinical practice, sporadic cases of toxic amblyopia have been observed, and therefore an ophthalmologist is required to consult with any visual impairment during the period of taking Ibufen.

With prolonged use of NSAIDs can lead to damage to the mucous membranes of the digestive tract,peptic ulcers and bleeding from the digestive tract, so you need to monitor the picture of peripheral blood and the functional state of the liver and kidneys.

Do not administer Ibufen concurrently with other NSAIDs.

When symptoms of gastropathy appear, careful monitoring of the patient's condition is shown, including esophagogastroduodenoscopy, blood tests and determination of hemoglobin, hematocrit, fecal occult blood test.

Drug Interactions

With simultaneous application of Ibufen with indirect anticoagulants, SCS increases the risk of bleeding.

With simultaneous application, Ibufen weakens the effect of antihypertensive drugs (ACE inhibitors, beta-adrenoblockers), diuretics (furosemide, thiazide diuretics).

With the simultaneous use of ibuphen improves the toxicity of methotrexate.

When combined, inducers of microsomal oxidation (phenytoin, ethanol (alcohol), barbiturates, zixorin, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of developing severe hepatotoxic reactions.

When combined, Ibuphen can displace indirect blood clots (acenocumarol), hydantoin derivatives (phenytoin), oral hypoglycemic drugs (sulfonylureas) from blood plasma protein compounds.

With simultaneous application, Ibuphen slows the excretion of lithium salts.

When combined, ibuprofen increases the concentration of Digoxin in the blood.

Caffeine increases the analgesic effect of ibuprofen.

Analogues of the drug Ibufen

Structural analogs for the active substance:

• Advance;
• Advil for children;
• ArthroCam;
• Bonifen;
• Brufen;
• Brufen retard;
• Burana;
• Deblock;
• Children's Motrin;
• Dolgit;
• Ibuprom;
• Ibuprom Max;
• Ibuprom Sprint Caps;
• Ibuprofen;
• Ibuprofen for children;
• Ibusan;
• Ibutop gel;
• Iprene;
• MIG 200;
• MIG 400;
• Nurofen;
• Nurofen for children;
• Nurofen Rapid Forte;
• Nurofen UltraKap;
• Nurofen fort;
• Nurofen Express;
• Pedee;
• Sedaling the Sprint;
• Solpaflex;
• Faspik.

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