Vormil - instructions for use, analogs, reviews and release forms (400 mg tablets, suspension for ingestion) of a drug for the treatment of ascaridosis, enterobiasis and other worms in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Vormil. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Vormil in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Vormil with available structural analogues. Use for the treatment of ascariasis, enterobiasis and other worms in adults, children,as well as during pregnancy and lactation. Composition of the preparation.
Vormil - an anthelmintic preparation with a wide spectrum of action. The active substance is albendazole. Albendazole is effective in the tissue and intestinal forms of parasitic diseases. It works both on adult helminths, and on their larvae and eggs. The anthelmintic effect is due to the ability of albendazole to suppress the polymerization of tubulin, which causes a disturbance in the metabolism of helminths with their further death.
It has an effect on intestinal worms (Enteromius vermicularis nematodes, Ascaris lumbricoides, Trishiurus trišiura, Strongiloides stercoralis, Necator americanus, Cutaneous Larva Migrans Ancylostoma duodenale, cestode Taenia solium, Hymenolepsis nana, Taenia saginata, tremorod Clonorchis sinensis and Opisthorhis viverrini), and also the simplest organisms (Giardia lamblia). It is active in tissue helminthiases (Echinococcus granulosus - cystic echinococcosis and Echinococcus multilocularis - alveolar echinococcosis). Albendazole is also effective in treating invasions of T. Solium larvae (neurocystercercosis) and Gnatostoma spinigerum (capillary). When Vormila is used, granular echinococcus cysts decrease in size or are eliminated.
Composition
Albendazole + auxiliary substances.
Pharmacokinetics
After internal administration, Vormil from the gastrointestinal tract is absorbed poorly - up to about 5%.With the simultaneous use of albendazole, the consumption of fatty foods increases the absorption of the substance. At the primary passage through the liver is rapidly metabolized. The main metabolite, albendazole sulfate, is active at 50% of the action of the primary substance. The half-life is 8.5 hours. Metabolites of albendazole are excreted from the body with bile (predominantly) and urine (small amounts). When taken for a long time (in large doses for the treatment of cysts) excretion of metabolites from cysts is observed for several weeks.
Indications
With parasitic invasions:
- ankylostomiasis;
- enterobiosis;
- necropsy;
- shadows;
- strongyloidiasis;
- hymenolepiasis;
- ascaridosis;
- trichinosis;
- capillarial disease;
- trichinosis;
- skin migratory larvae;
- clonorhoz;
- neurocysticercosis;
- gnathostomosis;
- toxocarosis;
- giardiasis.
Forms of release
Tablets chewing 400 mg.
Suspension for oral administration 400 mg.
Instructions for use and reception scheme
Tablets or suspension
The dosage of Wormil is determined individually. The tablets are chewed before ingestion. With ankylostomiasis, ascariasis, enterobiosis, non-catarosis, trichinellosis in children more than 2 years and adults appoint 400 mg (1 tablet) once a day for 3-5 days.
In the case of shade, strongyloidosis and hymenolepiasis in children over 2 years and adults, 400 mg (1 tablet) are prescribed once a day for 3 days. In case of confirmed hymenolipidosis, it is necessary to repeat the course of therapy after 21 days.
With clonorchosis, opisthorchiasis, mixed invasion of Chlonorchis sinensis and Opisthorchis viverrini, children over 2 years and adults are prescribed 400 mg (1 tablet) 2 times a day for 3 days.
For the treatment of giardiasis for children from 2 to 12 years old, Vormil uses 1 tablet (400 mg) once a day for 5 days.
In the case of systemic helminth invasion, the dosage of Vormil depends on the patient's body weight, the type of parasite, and the severity of the disease.
With cystic echinococcosis for patients weighing more than 60 kg, the drug is prescribed 400 mg (1 tablet) 2 times a day. The course of treatment is 28 days. If the weight of the patient is less than 60 kg, it is prescribed at the rate of 15 mg / kg per day (divided into 2 doses). The maximum allowable dose is 800 mg per day. If necessary, 3 cycles of treatment with an interval of 2 weeks.
In alveolar echinococcosis, 400 mg (1 tablet) is prescribed twice a day for patients weighing more than 60 kg. We recommend 3 cycles of treatment for 28 days with an interval of 2 weeks. For patients weighing less than 60 kg, appoint at the rate of 15 mg / kg per day (divided into 2 doses). The maximum allowable dose is 800 mg per day.If necessary, the therapy can be continued for several months / years.
When invading Cutaneous larva migrans (cutaneous migratory larvae), Vormil is prescribed 400 mg (1 tablet) for 1-3 days.
For the treatment of neurocysticemia, 400 mg (1 tablet) are prescribed twice a day for patients weighing more than 60 kg. The course of therapy depends on the result and can last from 1 week to a month. For patients weighing less than 60 kg, appoint at the rate of 15 mg / kg per day (divided into 2 doses). The maximum allowable dose is 800 mg per day. The therapy cycle can be repeated after 7-14 days.
Adults and children with capillarial disease are prescribed 400 mg (1 tablet) once a day for 10 days.
Adults and children with gnathostomosis appoint 400 mg (1 tablet) once a day for 10-20 days.
Side effect
- nausea, vomiting;
- dry mouth;
- stomatitis;
- heartburn;
- flatulence;
- abdominal pain;
- diarrhea, constipation;
- headache;
- drowsiness or insomnia;
- dizziness;
- disorientation
- confusion of consciousness;
- hallucinations;
- convulsions;
- decreased visual acuity;
- hives;
- dermatitis;
- itching;
- pemphigus;
- fever;
- pancytopenia, leukopenia.
Contraindications
- pregnancy and lactation;
- hypersensitivity reactions to albendazole or other components of Wormil;
- age up to 2 years;
- pregravidarny (before pregnancy) period.
Application in pregnancy and lactation
Vormil categorically contraindicated during pregnancy and lactation. Before prescribing the drug, it is recommended to carry out a pregnancy test in order to prevent the use of Vormil in early periods.
Use in children
Contraindicated in children under 2 years. Can be used in children over 2 years of age in the appropriate dosages.
special instructions
Use with caution in cases of liver disorders (before and during treatment, its functions are regularly monitored).
If the norm of laboratory parameters is exceeded more than 2 times from the upper limit, the intake of Vormil is stopped until they are fully normalized. When treating with Vormil it is necessary to control the level of leukocytes at the beginning of each cycle and every 14 days of a 28-day course of therapy. In case of development of leukopenia, the drug is continued if leukopenia is insignificant and does not progress.
With neurocysticercosis with eye damage before starting treatment, it is necessary to study the retina of the eye (the risk of aggravation of its pathology).
For the prevention of helminthic invasions is not used (high stress on internal organs, especially in children).
Drug Interactions
It is possible to increase the concentration of metabolites of albendazole when combined with praziquantel, cimetidine and dexamethasone.
Analogues of the drug Vormil
Structural analogs for the active substance:
- Gelmodol BM;
- Nemosol;
- Sanoxal.
Analogues for the pharmacological group (anthelmintics):
- Biltricide;
- Vermox;
- Worming;
- Gelmodol BM;
- Helmintox;
- Decaris;
- Mebendazole;
- Medamin;
- Nemosol;
- Nemocide;
- Piperazine;
- Pirantel;
- Piervinium;
- Sanoxal;
- Telmox 100.
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