Alpha Normix - instructions for use, reviews, analogs and formulations (200 mg tablets, granules for the preparation of a suspension) for the treatment of colitis, diarrhea, gastroenteritis in adults, children and pregnancy. Composition of antibiotic

In this article, you can read the instructions for using the drug Alpha Normix. Comments from visitors to the site - consumers of this medication, as well as opinions of physicians specialists on the use of Alpha Normix in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Alfa Normix in the presence of existing structural analogs.Use for the treatment of colitis, diarrhea, gastroenteritis in adults, children, as well as during pregnancy and lactation. Composition and interaction of antibiotic with alcohol.

Alpha Normix - broad-spectrum antibiotic, is a semisynthetic derivative of rifamycin SV. Irreversibly binds the beta subunits of the enzyme of bacteria, DNA-dependent RNA polymerase and, consequently, inhibits the synthesis of RNA and bacterial proteins. As a result of irreversible binding to the enzyme, rifaximin exhibits bactericidal properties against sensitive bacteria.

The drug has a broad spectrum of antibacterial activity, including most gram-negative and gram-positive, aerobic and anaerobic bacteria that cause gastrointestinal infections, including travelers' diarrhea. It is active against gram-negative aerobic bacteria: Salmonella spp. (salmonella), Shigella spp. (Shigella), Escherichia coli (E. coli), enteropathogenic strains, Proteus spp., Campylobacter spp., Pseudomonas spp., Yersinia spp., Enterobacter spp., Klebsiella spp. (Klebsiella), Helicobacter pylori (Helicobacter pylori); Gram-negative anaerobes: Bacteroides spp., including Bacteroides fragilis, Fusobacterium nucleatum; Gram-positive aerobes: Streptococcus spp. (streptococcus), Enterococcus spp.(enterococcus), including Enterococcus fecalis, Staphylococcus spp. (staphylococcus); Gram-positive anaerobes: Clostridium spp., including Clostridium difficile and Clostridium perfrigens, Peptostreptococcus spp.

The use of the Alpha Normix drug helps to reduce the pathogenic intestinal bacterial load, which causes some pathological conditions.

The drug reduces:

• the formation by bacteria of ammonia and other toxic compounds, which in the case of severe liver disease, accompanied by a violation of the detoxification process, are involved in the pathogenesis of hepatic encephalopathy;
• increased bacterial proliferation in the syndrome of excessive growth of microorganisms in the intestine;
• presence in the diverticulum of the colon bacteria that may be involved in inflammation in and around diverticular sac and may play a key role in the development of symptoms and complications of diverticular disease;
• the intensity of the antigenic stimulus, which, in the presence of genetically determined defects in mucosal immunoregulation and / or protective function, can initiate or permanently maintain chronic inflammation of the intestine;
• risk of infectious complications in colorectal surgery.

Composition

Rifaximin + excipients.

Pharmacokinetics

Alpha Normix is ​​poorly absorbed when taken orally (less than 1%). In the gastrointestinal tract, very high concentrations of antibiotic are created, which are much higher than the MIC for proven enteropathogenic microorganisms.

The drug is not detected in the plasma after administration at therapeutic doses (detection limit is less than 0.5-2 ng / ml) or is detected in very low concentrations (less than 10 ng / ml in almost all cases) both in healthy volunteers and in patients with damaged mucosa intestine (as a result of ulcerative colitis or Crohn's disease). In fact, almost 100% of rifaximin ingested is in the gastrointestinal tract, where very high concentrations of the drug are achieved (concentrations in the stool of 4-8 mg / g are achieved after 3 days of taking the drug at a daily dose of 800 mg). The drug is excreted with feces. The rifaximin found in the urine is no more than 0.5% of the dose taken internally.

Indications

Treatment of gastrointestinal infections caused by bacteria susceptible to rifaximin, incl. when:

• acute gastrointestinal infections;
• travelers diarrhea;
• syndrome of excessive growth of microorganisms in the intestine;
• colitis and gastroenteritis;
• hepatic encephalopathy;
• symptomatic uncomplicated diverticular disease of the colon;
• chronic inflammation of the intestine.

Prevention of infectious complications in colorectal surgery.

Forms of release

The tablets covered with a cover of 200 mg.

Granules for the preparation of the suspension for ingestion 100 mg.

Other dosage forms, be it drops or capsules, do not exist.

Instructions for use and dosing regimen

Pills

Adults and children over 12 years of age the drug is prescribed 200 mg (1 tablet) every 8 hours or 400 mg (2 tablets) every 8-12 hours. If necessary, the dose and frequency of admission can be changed under the supervision of a doctor.

The duration of treatment should not exceed 7 days and is determined by the clinical condition of patients. If necessary, a second course of treatment should be carried out no earlier than in 20-40 days. The total duration of treatment is determined by the clinical condition of the patient.

Granules for the preparation of suspension

Adults and children over 12 years of age are prescribed 200 mg every 8 hours or 400 mg every 8-12 hours. If necessary, the dose and frequency of admission can be changed under the supervision of a doctor.The duration of treatment should not exceed 7 days and is determined by the clinical condition of patients. The repeated course of treatment should be carried out no earlier than in 20-40 days.

Side effect

• palpitation;
• flushes of blood to the skin of the face;
• increased blood pressure;
• lymphocytosis, monocytosis, neutropenia;
• dizziness;
• headache;
• loss of taste;
• hypoesthesia;
• migraine;
• insomnia;
• pathological dreams;
• diplopia;
• systemic dizziness;
• dyspnea;
• dryness in the throat;
• nasal congestion;
• pain in the laryngopharyngeal region;
• bloating;
• abdominal pain;
• constipation, diarrhea;
• flatulence;
• nausea, vomiting;
• tenesmus;
• desires for defecation;
• anorexia;
• ascites;
• dyspepsia;
• violation of motility of the digestive tract;
• excretion of mucus and blood with feces;
• dry lips;
• hard stool;
• increasing the activity of AST;
• glucosuria;
• polyuria;
• pollakiuria;
• hematuria;
• rash (including macular);
• cold sweat;
• back pain;
• muscle spasm;
• muscle weakness;
• myalgia;
• polymenorea;
• candidiasis;
• fever;
• asthenia;
• pain in the chest;
• unpleasant sensations in the chest;
• chills;
• fatigue;
• influenza-like symptoms;
• peripheral edema.

Contraindications

• intestinal obstruction (including partial obstruction);
• severe ulcerative bowel disease;
• children under the age of 12;
• hypersensitivity to the components of the drug;
• increased sensitivity to rifaximin or other rifamycins.

Application in pregnancy and lactation

In pregnancy and lactation (breastfeeding), the drug is only possible in case of emergency and under the direct supervision of a doctor.

Use in children

In children under 12 years of age, the drug is not used.

Children over 12 years of age are prescribed 200 mg (1 tablet) every 8 hours or 400 mg (2 tablets) every 8-12 hours. If necessary, the dose and frequency of admission can be changed under the supervision of a doctor.

special instructions

During prolonged treatment with the drug in high doses or with damage to the intestinal mucosa, it is possible to absorb a small amount of Alpha Normix (less than 1%), which can cause urine to become reddish: this is due to the active substance rifaximin, which, like most antibiotics of this series rifamycin), has a reddish-orange color.

Antibiotic Alpha Normix is ​​taken regardless of the intake of food (can be taken before or after meals).

It is forbidden to use the drug together with ethanol (alcohol).

With the development of superinfection by microorganisms insensitive to rifaximin, Alfa Normix should be discontinued and appropriate therapy should be prescribed.

Drug Interactions

Until now, the drug interaction of the drug Alpha Normix has not been established.

Due to poor systemic absorption (less than 1%), drug interactions at the systemic level are unlikely.

Analogues of the drug Alpha Normix

Alpha Normix does not have structural analogs for the active substance.

Analogues for the pharmacological group (Ansamycins):

• Benemycin;
• Verbutin;
• McCox;
• Mycobutin;
• Otofa;
• Pentacox;
• P-zinc;
• Rimactan;
• Rimpacine;
• Rimpin;
• Rifabutin;
• Rifadine;
• Rifamor;
• Rifampicin;
• Rifapex;
• Rifaren;
• Rifogal;
• Farbutin;
• Eremfat.

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